Protein Alignment Eps-15 and eps15

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_002663145.4
• Gene: eps15 / 795505
• ZFINID: ZDB-GENE-081104-264
• Length: 1039
• Species: Danio rerio
• Alignment Length: 1074
• Identity: 306/1074 - (28%)
• Similarity: 458/1074 - (42%)
• Gaps: 308/1074 - (28%)

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            |||.||:.:||..:|.:.|..||.|||:|||:|:||.:||||:|...||.|:|..|||||:||:.
Zfish    16 VYEKYYRQVDPSSSGHVGAGDAALFLKRSGLADLVLGKIWDLADSECKGSLNKQQFFVALRLVAC 80

  Fly    80 SQAG-QVASMANIYLDIANPPKLGELPK----TMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQ 139
            :|.| :||..:   |:.|.||     ||    :.|.:...||      |:..|.:...:::|::.
Zfish    81 AQNGLEVAYKS---LNTAVPP-----PKFHDTSSPLQFGPVP------ADTPWVVKAEEKVKFDA 131

  Fly   140 LFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKR 204
            :|:||.|..|||.|:|||.||::||||:.:||.:|:|:|.|:||.||..||.|||:|||:.|:..
Zfish   132 IFDSLSPVGGMLTGDKVKPVLLNSKLPVDVLGRVWELSDIDRDGMLDKDEFAVAMYLVYRALESE 196

  Fly   205 TIP-----SVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAA 264
            .:|     :::||..||| .:.||..|.:|.|........|.||
Zfish   197 MVPMSLPAALIPPSKRKP-ASSPPVMPLLPSPAQHKERNSAHSG--------------------- 239

  Fly   265 IPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDK 329
                       ::..|..|..||                    |||:|||..:::::|.::|.|.
Zfish   240 -----------SKTLPAKATPSQ--------------------WVVSPADKAKYDDLFAKTDTDM 273

  Fly   330 DGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVLN 393
            ||||||.||:|||:|:|:|..:||.||.|||....||||.:|||||::.:.:| .:|::||..|:
Zfish   274 DGLVSGAEVRDIFLKTGLPSATLARIWELCDIGDVGKLTRDQFALALYLINQKLSKGIEPPQTLS 338

  Fly   394 ANMVPPSMR-------ATVAGVDLQPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQKEAD 451
            ..|:||..|       .|:...|.  ..:|      ||:.::.||.:|.:|:.|:|.:|..:|..
Zfish   339 PEMIPPPDRLARQNNAVTLQAADF--SAIK------ELDSLTNEIMDLQKEKSVVEQDIKDREET 395

  Fly   452 VRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVT 516
            :|.:..||:.||.|:...:..|.:|:.:|.|.|::|:.|..|         ..||:     ||:|
Zfish   396 IRQRTSEVQDLQEEVQKGSDELGRLQAERQEVQEKLERLDEQ---------KRSLE-----EQLT 446

  Fly   517 KIRDQCHM--------------QEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKL 567
            .|:.||..              ||..|::.|.||...|.||..|::|...|.::..|...:|..|
Zfish   447 LIQQQCSQESQLIQSLQVQHSEQEQRISDYEEELTRAREELLHLQEETRQLGEKVQSARAQLCPL 511

  Fly   568 TNHLQATQLQISSVRSMVTQLLETQRQMT---------DALLICRAAM----------------- 606
            .:.::.:..||...:..:::|...:|::|         :.:|:..||.
Zfish   512 EDAVKESHTQIVQEQERLSELKMEEREVTARLTWKILEEPVLVNGAAPSIEHPEPLQWPQPTAQP 576

  Fly   607 -----------ENQNAELVSEYQLKI--------------------------------------- 621
                       |.:.:......:||:
Zfish   577 PETTKEDKVQDEEEQSSTDEPQELKVTEEEPGSEAEEPSSSPEQQESKPELYSYDLYNSAFSTIS 641

  Fly   622 ----------------EPDFDEARKTLTKE---VQLPKDDPFEENNSGAANQAT-------NGFG 660
                            |.:.||.|:. |:|   ...||.:..|......|...|       :|.|
Zfish   642 STSVNWPQGNTENTTQEAEVDEEREN-TEERPATSTPKAETVEPEKRETAQPDTEPPSNPPSGPG 705

  Fly   661 -----------SDPFSGQPVNKPAISTGF-DDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFG 713
                       ||||:..|..|..||..| .|.|..:..|.:  |.|.:..:||.   ..||||.
Zfish   706 LDFFQSDPFTDSDPFTEDPFAKVDISDPFGGDPFKGTDPFAA--DNFFKQSSGSF---PSRDPFS 765

  Fly   714 S------------DAFAANKSNAITPEP---------GKDDFG--------SDPFAALHA---PT 746
            |            |.|.:..:||:||:|         ..|.||        ||||::...   |.
Zfish   766 SSDPFNTTGPKEPDLFTSKTTNAVTPDPFASSSGNLQDTDPFGSKMDALADSDPFSSSGTGPDPF 830

  Fly   747 GQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGG-GGGFADF--- 807
            |...|::    :.||....:..:|......:...|.:..|..|.     ||:.. |||||||
Zfish   831 GGSDVVA----RDGPASANDPFAPGGTTVVANSDPDKTDPFAAV-----FGNETFGGGFADFSSL 886

  Fly   808 ------DDFD---NKLHHIPSAPSPSATALSPL--PPTLPAPIPVVSGSSL--LDSFTLFDDPGQ 859
                  |.||   ||........|....||.|.  .||.|.|.|....|::  .:|...|...|.
Zfish   887 AKSNGNDPFDSSTNKNLFKEDTQSDVPPALPPKTGTPTRPPPPPPGKRSNIHRSESSESFHRRGL 951

  Fly   860 IHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPS 893
            ...|.::..:..|         .:.|:..|.|||
Zfish   952 FKAQGSAEFSSLP---------AKDSVPDPFAPS 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	35/65 (54%)
		EH	126..215	CDD:197477	41/93 (44%)
		EH	307..402	CDD:197477	47/95 (49%)
		SMC_prok_B	<423..>632	CDD:274008	62/314 (20%)
eps15	XP_002663145.4	None