DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eps-15 and ITSN1

DIOPT Version :10

Sequence 1:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster
Sequence 2:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens


Alignment Length:1105 Identity:251/1105 - (22%)
Similarity:405/1105 - (36%) Gaps:317/1105 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQD 180
            |...||..: .|:|.|.:|.|::|.|.||.|.:|.:.|::.:.....|.||..:|..||.|||.:
Human     5 PTPFGGSLD-IWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMN 68

  Fly   181 KDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP------------GG-AGPPPKPAMPPPP 232
            .||.:|..||.:||.|:...||...:||.|||.:::.            || |..||..|:.|.|
Human    69 NDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVP 133

  Fly   233 AGA--AMPRAPSGEGFGDGGFVANFPKDIAPPAA------IPPLPVAVPPMTRIPPVGAVS-SQP 288
            .|:  .:..:|:        .|::.|....||.|      |.|||....|...:|...:.| |.|
Human   134 MGSIPVVGMSPT--------LVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190

  Fly   289 LIQTDPLIPIG-----APVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIP 348
            ..|.:..:...     |.|...|:|.|..:...::.::|...|....|.::|.:.:.|.::|.:|
Human   191 GSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLP 255

  Fly   349 QRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAG------ 407
            |..||.||.|.|.:|.||||.|:|.|||..::....|...|.||....:|||.|...:|      
Human   256 QAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVI 320

  Fly   408 ----VDLQ-PQE-------------VKPTYSNPELEMISKEIEELARER------------RVLE 442
                ||.: |:|             :..|:.:.:.|...:...||.:.|            |:.:
Human   321 SSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQ 385

  Fly   443 TEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLD 507
            .|.|::|...|.:..:.|..|.||:      ||||.||...::|.::.:.::....|.       
Human   386 LERAEQERKERERQEQERKRQLELE------KQLEKQRELERQREEERRKEIERREAA------- 437

  Fly   508 ISRTNEQVTKIRDQCHMQEVTINEQEGE------LNAKRS----ELQKLKDEEASLQKEYDSNNR 562
             .|..|:..::..:.:.::..:|::..|      |.||:.    ||:.|.|::..|:.:......
Human   438 -KRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRC 501

  Fly   563 ELSKLTNHLQAT----QLQISSVRSMVTQLLETQRQM-----------------------TDALL 600
            .|:.....:::|    :|:|:.:..:..||.|:|:.:                       .|:|:
Human   502 RLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLV 566

  Fly   601 ICRAAME----------NQNAELVSEYQLKIEP------DFDEARKTLTKEVQLPKDDPFE---- 645
            ..:.|:|          :|..|:..|.:.|::.      ...|.|:...|: ||.|....|    
Human   567 TLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ-QLQKQKSMEAERL 630

  Fly   646 ----------------ENNSGAANQATNGFGSDPFSGQPVNKP-----AISTGFDDSFNMSSGFD 689
                            |.....|.:....:...........:|     ......::|.....|.:
Human   631 KQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695

  Fly   690 SGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAP--TGQGQVL 752
            .|... .|...|..|.|.|                   ||.|        .|:.||  |.:...|
Human   696 KGKQE-AQDKLGRLFHQHQ-------------------EPAK--------PAVQAPWSTAEKGPL 732

  Fly   753 SPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPP--------------RAAQP--TGGFGSGGG 801
            :.:||::.......    ||.|.:|:........|              :..:|  .||...|..
Human   733 TISAQENVKVVYYR----ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT 793

  Fly   802 GGFADFDDFDNKL--HHIPSAPSPSATALSPLPPTL-----PAPIPVVSGSSLLDSFTLFDDPGQ 859
            |.|.  .::..|:  :.:|:...|...:.|...|.|     |||:.|.|                
Human   794 GWFP--ANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS---------------- 840

  Fly   860 IHKQAASTPN---------PT------------------PITVPTVHTLLQTSLSTPA-----AP 892
              .:.::|||         ||                  .:|||:...|.|.|..|||     :|
Human   841 --SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903

  Fly   893 SPALASLSTSGSG-SVAGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSV 956
            ||.|      |.| .|.|..|                    ::..|.:.::...:......|::|
Human   904 SPVL------GQGEKVEGLQA--------------------QALYPWRAKKDNHLNFNKNDVITV 942

  Fly   957 FDA-----FGEIGTRKAPTP----SLITGPTDFKDDPFKDYRYEDPFSIK---DPFAE---EGEE 1006
            .:.     |||:..:|...|    .||:||.. |.........|.|.|:|   .|.|:   .|||
Human   943 LEQQDMWWFGEVQGQKGWFPKSYVKLISGPIR-KSTSMDSGSSESPASLKRVASPAAKPVVSGEE 1006

  Fly  1007  1006
            Human  1007  1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps-15NP_611965.2 EH 16..82 CDD:238009
EH 126..215 CDD:197477 36/88 (41%)
EH 307..402 CDD:197477 33/94 (35%)
SMC_prok_B <423..>632 CDD:274008 51/273 (19%)
ITSN1NP_003015.2 EH 14..108 CDD:197477 36/93 (39%)
EH 214..309 CDD:197477 33/94 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348 4/25 (16%)
KLERQ 326..702 66/391 (17%)
Smc <363..>684 CDD:440809 58/335 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 5/51 (10%)
SH3_Intersectin1_1 744..803 CDD:212920 11/64 (17%)
INTAP 803..917 CDD:435467 33/137 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 7/49 (14%)
SH3_Intersectin1_2 917..968 CDD:212922 9/70 (13%)
SH3_Intersectin1_3 1006..1057 CDD:212924 1/1 (100%)
SH3_Intersectin1_4 1074..1138 CDD:212926
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127
SH3_Intersectin1_5 1158..1211 CDD:212928
RhoGEF 1238..1421 CDD:238091
PH_13 1440..1582 CDD:465218
C2_Intersectin 1582..1716 CDD:176021
Blue background indicates that the domain is not in the aligned region.

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