DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eps-15 and pan1

DIOPT Version :9

Sequence 1:	NP_611965.2	Gene:	Eps-15 / 37961	FlyBaseID:	FBgn0035060	Length:	1253	Species:	Drosophila melanogaster
Sequence 2:	NP_001342822.1	Gene:	pan1 / 5802955	PomBaseID:	SPAC25G10.09c	Length:	1794	Species:	Schizosaccharomyces pombe

Alignment Length:	1085	Identity:	212/1085 - (19%)
Similarity:	375/1085 - (34%)	Gaps:	316/1085 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 IPSVLPPELRKPGGAGP--PPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAP------- 261
            :|.:..|...:..|..|  |.:..|.|...|...|.||...|.          :.:||
pombe   694 MPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGM----------QPMAPQRTGMQP 748

  Fly   262 -----------PAAIPPLPVAVP--------PMTRIPPVGAVSSQPLIQTDPLIPIGA-----PV 302
                       ...:.|.|..:|        |::.:|.:.|:..|.:    |..|.|.     ..
pombe   749 QMTGGPMLPQRTGGMAPQPTGMPGQWGFINTPLSNLPGIEALGQQMM----PNAPSGGLNNTFQQ 809

  Fly   303 MANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKL 367
            ..:..|.::..:.:.:::||...|.::.|.:.|..|.:||.:|.:.:..|..||.|||....|.|
pombe   810 KKDIPWAISKEEKRIYDQIFDAWDKERKGTLGGNAVLEIFGQSKLTRTELEHIWNLCDHGDKGSL 874

  Fly   368 TVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVA-------------------GVDLQPQ 413
            ..::||:|:..:.||..|.:.|.||...::|||.|....                   |.:.|.:
pombe   875 DRDEFAVALHLIYRKLNGNEVPAVLPPELIPPSTRNFTESLNQVKNLIKNDTSNRKPFGAENQSK 939

  Fly   414 EVKPT-YSNPELEMISKEIE-------------ELARERRVLETEIAQKEADVRIKNGEVRSLQS 464
            ..|.: |.||. |...|:..             ..||.|...|.:|......:...:.|:.||:.
pombe   940 LKKNSFYDNPS-ETTEKDATLYRHNDSDASAYVSSARRRDFKEEKIESAPPIINDIDSEIASLKK 1003

  Fly   465 ELDTLTATLKQLENQR------GEAQK-----RLDDLQAQVSHNTAVLANVSLDISRTNEQVTKI 518
            .:...:..:..||:::      .:.|.     |:..:|.::  |....:|.|.:::..|.::.::
pombe  1004 RIHEKSLVVNALEDKKLAATPANDVQNDSLIYRIKSVQDEI--NRLSTSNKSPEVASMNVRLEEL 1066

  Fly   519 RDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRS 583
            ..:.......|||.:..:.:...:|.:.:|.:.|    ||..:.|.::..|            |:
pombe  1067 STRVSKMLSDINEVDHTIASLSLKLFQAEDTKNS----YDQTSPEATQERN------------RT 1115

  Fly   584 MVTQLLETQRQMTDALLICRAAME---NQNAELVSEYQLKIEPD------------FDEARKTLT 633
            :.::|.|.::|..::    :||:|   |....:.:..:.|:.|.            .||:...:.
pombe  1116 ISSKLAEMEKQKNES----KAALEQMKNYVTNIENNIRAKLLPSAANDDAWLSQNVVDESVTRVV 1176

  Fly   634 KEVQLP-----------------KDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAISTGFDD- 680
            ||:.:|                 :..|.|.|......:||:            ..|:.|:..:|
pombe  1177 KELPVPAPAAPQTLNPPSVSTVQQSKPIESNTHTPEVKATS------------ESPSASSNLEDR 1229

  Fly   681 ----SFNMSSGFDSGFDAFG----QSGAGS------------AFGQTQRDPFGSDAFAANK---- 721
                ........:....|.|    |.|..|            |....|:...|..|.|.:.
pombe  1230 AARIKAEAQRRMNERLAALGIKPRQKGTPSPAPVNSATSTPVAAPTAQQIQPGKQASAVSSNVPA 1294

  Fly   722 -SNAIT-----------PEPGKDDFGSDPFAALH-----------APTGQGQVLSPNAQKSG--P 761
             |.:|:           |:|.|    ..|.||:.           ||..|...|.....|..  |
pombe  1295 VSASISTPPAVVPTVQHPQPTK----QIPTAAVKDPSTTSTSFNTAPIPQQAPLENQFSKMSLEP 1355

  Fly   762 PPR---PESPSPALPPKKSKVPPPRPAPPRAAQPT--------------GGFGS-GGGGGFADFD 808
            |.|   |.||.|.:|...:...||.|..|..|.|:              ..||| ..|...:..:
pombe  1356 PVRPAVPTSPKPQIPDSSNVHAPPPPVQPMNAMPSHNAVNARPSAPERRDSFGSVSSGSNVSSIE 1420

  Fly   809 DFDNKL--------------HH----IPSAP----------SPSATALSPLPPTLPAPIPVVSGS 845
            |..:.:              :|    :|.||          :|.....:|.|.:.|||
pombe  1421 DETSTMPLKASQPTNPGAPSNHAPQVVPPAPMHAVAPVQPKAPGMVTNAPAPSSAPAP------- 1478

  Fly   846 SLLDSFTLFDDPGQIHKQAASTPN-PTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGS--GSV 907
                       |..:.:...:.|| |.|..:|:|.....:|::...|||..|....:|.:  .|.
pombe  1479 -----------PAPVSQLPPAVPNVPVPSMIPSVAQQPPSSVAPATAPSSTLPPSQSSFAHVPSP 1532

  Fly   908 AGAGADLPSSVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPS 972
            |......||:..:::||:.|:  :...::|...|....   :.:|:.::..| ..:||.::.:|.
pombe  1533 APPAPQHPSAAALSSAPADNS--MPHRSSPYAPQEPVQ---KPQAINNIAPA-TNLGTSQSFSPR 1591

  Fly   973 LITGPTDFKDDPF-----------------KDYRYEDPFS-----IKDPFAEEGEEELSEGKGAD 1015
            :  ||.:....|.                 ....:.:||:     ...|....|.:..:..:..|
pombe  1592 M--GPVNNSGSPLAMNAAGQPSLAVPAVPSAPSNHFNPFAKMQPPAPSPLQPSGHDSDNWSQHGD 1654

  Fly  1016 HKRNFAED--FSSGDEIGSAAKTLSNI-----VNNNSIKPKAATP 1053
            .:...:||  .||.|....|||....:     |:...::|::|.|
pombe  1655 EEEEDSEDDIRSSKDAAALAAKLFGGMAPAHPVSTPPVRPQSAAP 1699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	2/8 (25%)
		EH	137..202	CDD:238009
		EH	307..402	CDD:197477	30/94 (32%)
		EH	318..384	CDD:238009	22/65 (34%)
		RILP-like	<445..548	CDD:304877	17/113 (15%)
		Spc24	529..>584	CDD:285486	11/54 (20%)
pan1	NP_001342822.1	DUF1720	177..262	CDD:311924
		EH	276..368	CDD:197477
		DUF1720	422..508	CDD:311924
		Med15	473..>796	CDD:312941	21/115 (18%)
		EH	814..909	CDD:197477	30/94 (32%)
		SMC_N	<976..>1150	CDD:330553	33/195 (17%)
		Atrophin-1	<1180..1637	CDD:331285	93/498 (19%)
		WH2	1746..1772	CDD:308040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0998
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910