Protein Alignment Eps-15 and itsn2b

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_005158835.2
• Gene: itsn2b / 445153
• ZFINID: ZDB-GENE-050309-102
• Length: 1837
• Species: Danio rerio
• Alignment Length: 651
• Identity: 175/651 - (26%)
• Similarity: 278/651 - (42%)
• Gaps: 152/651 - (23%)

  Fly   127 WSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFV 191
            |:|...:|.|::|.|:||.|:.|.:.|.|.:...:.|.||..:|..||.|||.:|||.:|..||.
Zfish     8 WAITPEERDKHDQKFDSLLPAQGYVTGEKARNFFIQSGLPQPVLAEIWALADMNKDGKMDRLEFS 72

  Fly   192 VAMHLVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAG-AAMPRAPSGEGFGDGGFVANF 255
            :||.|:...||.:.:|:.||..:::|    |.|.|.||..|.| .|||..|         .:.|.
Zfish    73 IAMKLIKMKLQGQNLPTALPIIMKQP----PVPAPTMPAAPLGMGAMPNVP---------MMPNV 124

  Fly   256 P-KDIAPPAAIPPLPVAVP------PMTRIP-------PVGAV-----SSQPLIQTDPL------ 295
            | ....|.|.:.|:||..|      |::.:|       |.|.:     |..||..|.||
Zfish   125 PILTPIPMATMSPIPVMTPMMGTGLPVSMMPTISSQTLPNGPIAILQPSPMPLTSTLPLSSSFSA 189

  Fly   296 IPIG-------------------------------APVMANADWVVTPADLKRFEEIFRQSDLDK 329
            .|:|                               :|....:||.|..|...::.:.|...|...
Zfish   190 SPLGFSTTSMNKTSSLLDLGSSSSNSSPSTSLASNSPKGGPSDWGVPQASRLKYRQQFNSLDKLM 254

  Fly   330 DGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNA 394
            .|.::|.:|:.....:.:.|..||.||.|.|.::.|||..::|.|||..|:..:.|...|..|.:
Zfish   255 SGYLTGPQVRTAMATTLLTQTQLAAIWNLADVDKDGKLKADEFILAMHLVDMAKMGQPLPLALPS 319

  Fly   395 NMVPPSMRATV------------AGV--DL----QPQEVKPTYS------------NPELEMISK 429
            ::||||:|..:            ||:  ||    .||:.:...:            |.|||...:
Zfish   320 DLVPPSLRGRLGESMNGTTPSIYAGLAEDLCEPEPPQKSRNNLTFEDKFKKNMELGNAELEKRRQ 384

  Fly   430 EIEEL-----------------ARERRVLETEIAQK-EADVRIKNGEVRSLQ--------SELDT 468
            .::|.                 .|||...|.|:.:| |.::|::  ..|.|:        .||:.
Zfish   385 VLQEQQRREEERRAQKAREEQERREREARELELKRKREEEIRLE--RQRELERQREEERLKELER 447

  Fly   469 LTATLKQLENQR--GEAQKRLDDLQAQVSHNTAVLANV-----SLD-----ISRTNEQVT-KIRD 520
            ..|..|:||.|:  ...::|..:||.|.|.....:..:     ||:     :....:|:: |:||
Zfish   448 KEAAKKELERQQQLEWERRRKQELQNQKSEEQEDIIKLRAKKRSLEMELEAVGNKQKQISDKLRD 512

  Fly   521 QCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQ--ATQLQISSVRS 583
            ....:.:..||.| .:|.||   .....|.:||||:.:...|:|.:.|:..|  ..:|:..|:.|
Zfish   513 AQGRKRIHKNELE-MINQKR---DSCITEISSLQKQLEDFKRKLGQSTSEQQKLTDKLRSLSLNS 573

  Fly   584 MVTQLLET-QRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTL--TKEVQLPKDDPFE 645
            :.|..::| |..|.:..|.||...|..|| :..|...|: .|.|:.:|.:  .:|.|..::...|
Zfish   574 VPTATVKTLQNNMEEKDLSCRKLKEQLNA-VEKETAAKL-ADMDQYKKDIQDLRESQRMQESALE 636

  Fly   646 E 646
            :
Zfish   637 K 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	35/87 (40%)
		EH	307..402	CDD:197477	31/94 (33%)
		SMC_prok_B	<423..>632	CDD:274008	65/250 (26%)
itsn2b	XP_005158835.2	None