Protein Alignment Eps-15 and Eps15l1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_038950547.1
• Gene: Eps15l1 / 361120
• RGDID: 1565708
• Length: 927
• Species: Rattus norvegicus
• Alignment Length: 948
• Identity: 344/948 - (36%)
• Similarity: 471/948 - (49%)
• Gaps: 182/948 - (19%)

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            :||:|||.:||..||.:.|..||.|||||||||:||.:||||:||.|||||||.||:|||:||:.
  Rat    18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIVLGKIWDLADPEGKGFLDKQGFYVALRLVAC 82

  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESL 144
            :|:|...:::|:.|.:. |||..:....:        :|:...|...|::.|.::.|::.:||||
  Rat    83 AQSGHEVTLSNLGLTMP-PPKFHDTSSPL--------MATQSSAEAHWAVRVEEKAKFDGIFESL 138

  Fly   145 HPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSV 209
            .|.||:|.|:|||.|||:||||:.:||.:|||:|.||||:||..||.|||||||:.|:|..:|||
  Rat   139 LPVNGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSV 203

  Fly   210 LPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPP 274
            |||             |.:||...                       |......|:|.||.:.||
  Rat   204 LPP-------------PLIPPSKR-----------------------KKTVFAGAVPVLPASPPP 232

  Fly   275 ---MTRIPPVGAVSSQPLIQTDPLIPIGA-----PVMANADWVVTPADLKRFEEIFRQSDLDKDG 331
               :...|..|:|||  |..|..|.|..:     |.:|   |||..||..||:|||.::|||.||
  Rat   233 KDSLRSTPSHGSVSS--LNSTGSLSPKHSVKQTQPPVA---WVVPVADKMRFDEIFLKTDLDLDG 292

  Fly   332 LVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVLNAN 395
            .|||.|||:||:.||:.|..||.||||.||.|:|||:.|||||||:|:::| .:|:|||.||:.:
  Rat   293 YVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFALAMYFIQQKVSKGIDPPQVLSPD 357

  Fly   396 MVPPSMRATVAGVDLQPQEVKPTYSN-----PELEMISKEIEELARERRVLETEIAQKEADVRIK 455
            |||||.|.|..     |.......|.     .||:.||:||.:|.||:..||.:|.:||..:|.|
  Rat   358 MVPPSERGTPI-----PDSSSALGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQK 417

  Fly   456 NGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRD 520
            ..||:.||::||..|::|::||.|:.:||.|||::..|.:....:|::|........:.::.::.
  Rat   418 ASEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQTISSLKT 482

  Fly   521 QCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMV 585
            |...||..:..||.:||..:|||.:|:.||..|::...:...:|..:...|:.||..|:..||.:
  Rat   483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKL 547

  Fly   586 TQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLP---------KD 641
            :||.|:..:...:|     ...:|..:.||...|   ||.    .||.:.:.|.         ||
  Rat   548 SQLQESHLEAHRSL-----EQYDQVPDGVSGTSL---PDL----ATLNEGILLAERGGFGAMVKD 600

  Fly   642 DPFE------ENNSGAAN----QATNGF------GSDPFSGQPVNKPAIS---TGFDDSFNMSSG 687
            |||:      .|||...:    ||.:.|      |:|||.|.|......|   |...|.|.....
  Rat   601 DPFKNKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAVTDPFGGDPF 665

  Fly   688 FDSGFDAFGQSGAGSAF-GQTQRDPFGSDAFAANKS--NAITPEPGKDDF--------GSDPFAA 741
            .:|  |.|..|.:...| .||:.|||.||.|..|.|  :.:.|....|.|        |||||..
  Rat   666 KES--DPFHSSTSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGT 728

  Fly   742 LHAPTGQGQVLSPN-----AQKSGPPP------------------RPESPSPALPPKKSKVPPPR 783
            |. |.|.....|..     :|.|.|||                  :.:..:|||||||.  .|||
  Rat   729 LD-PFGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKP--APPR 790

  Fly   784 PAPPRAAQPTGGFGS------GGGG------GFADF---------------DDFDNKLHHIPSAP 821
            |.||..| ..|..||      ||..      |.:.|               |.|.||     ...
  Rat   791 PKPPSEA-AAGQKGSVVYTLLGGQSTPVSQLGSSAFPESPDPFQPLEADSGDPFQNK-----KGF 849

  Fly   822 SPSATALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQ 859
            ....:...|..|:..|..|..|.|...| ||.|.:..|
  Rat   850 GDPFSGKDPFAPSSSAKPPKASSSGFAD-FTSFGNEEQ 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	43/65 (66%)
		EH	126..215	CDD:197477	51/88 (58%)
		EH	307..402	CDD:197477	58/95 (61%)
		SMC_prok_B	<423..>632	CDD:274008	66/208 (32%)
Eps15l1	XP_038950547.1	EH	19..85	CDD:238009	43/65 (66%)
		EH	121..214	CDD:197477	54/105 (51%)
		EH	268..364	CDD:197477	59/98 (60%)
		COG4372	381..>598	CDD:443500	69/228 (30%)