Protein Alignment Eps-15 and Eps15

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_038965889.1
• Gene: Eps15 / 313474
• RGDID: 1305550
• Length: 933
• Species: Rattus norvegicus
• Alignment Length: 893
• Identity: 280/893 - (31%)
• Similarity: 423/893 - (47%)
• Gaps: 199/893 - (22%)

  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79
            |||.||:.::...||.:.|:.||.|||||||.|::|.:||||:|..|||.|:|..||:||:||:.
  Rat    18 VYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVAC 82

  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGG--VANGDWSIGVIDRLKYEQLFE 142
            :|.|...|:::  |::|.||     |:...|   :.|:.:.|  ||...|::...|:.||:.:|:
  Rat    83 AQNGLEVSLSS--LNLAVPP-----PRFHDS---SSPLLTSGTSVAELPWAVKSEDKAKYDAIFD 137

  Fly   143 SLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIP 207
            ||.|.:|.|.|:|||.||::||||:.|||.:|:|:|.|.||.||..||.|||.|||..|:|..:|
  Rat   138 SLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVP 202

  Fly   208 SVLPPELRKPGGAGPPPKPAMPPPPAGA--AMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPV 270
            ..|||.|       .||........:|:  |:|.:.:.|.:..
  Rat   203 MSLPPAL-------VPPSKRKTVSISGSMWAIPSSAAKESYHS---------------------- 238

  Fly   271 AVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSG 335
                   :||||            :.|..||:   ..|||:||:..:::|||.::|.|.||.|||
  Rat   239 -------LPPVG------------ISPTKAPL---RQWVVSPAEKAKYDEIFLKTDKDMDGYVSG 281

  Fly   336 LEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQ-RGVDPPHVLNANMVPP 399
            |||::.|:|:|:|...||.|||||||...|||:.:|||||...:.:|. :|:||||.|...|:||
  Rat   282 LEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPP 346

  Fly   400 SMRATVAGVDLQPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQS 464
            |.::::....:....|....:..||:.::.||.:|.||:..:|.::.:||..||.:..|.:.||.
  Rat   347 SDKSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQD 411

  Fly   465 ELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCHMQEVTI 529
            |:...:..|::|:.|:.:.|:.||:|..|.:.....|..|....:...:.::.::.:...||..|
  Rat   412 EVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQI 476

  Fly   530 NEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVR-SMVTQLLETQR 593
            :..|.||:..|.||.:|:.|.|.|::..:|...:|..|..|||.:|.:|||:: .:..:.|||..
  Rat   477 STYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDN 541

  Fly   594 QMTD------ALLICRAA------------------MENQN------------------------ 610
            ..::      ::|:..||                  .|.||
  Rat   542 NQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDV 606

  Fly   611 ---AELVSEYQL-KIEPDFDEARKTLTKEVQLPKDDPFEENNSGAAN----------QATNGFGS 661
               :|:|:...: |:.|.||:.:.  :||     :|||...:|...:          |:....||
  Rat   607 TDESEVVTAADIEKVSPRFDDDKH--SKE-----EDPFNVESSSLTDAVADTNLDFFQSDPFVGS 664

  Fly   662 DPFSGQPVNKPAISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPF---GSDAFAANKSN 723
            |||...|..|  |.....|.|..|..|.|  |.|        |.||..|||   .:|.|:|:.::
  Rat   665 DPFKDDPFGK--IDPFGGDPFKGSDPFAS--DCF--------FKQTSTDPFATSSTDPFSASSNS 717

  Fly   724 AITP----------EPG-----KDDFGSDPFAALHA------------------------PT--- 746
            :.|.          .||     ..|..:||||::..                        ||
  Rat   718 SNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISS 782

  Fly   747 GQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTG 794
            ....|:.|.......|.:.|...||||||..  .|.||.||    |.|
  Rat   783 SASSVVIPKPVLEETPSKSEDVPPALPPKTG--TPTRPCPP----PPG 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	34/65 (52%)
		EH	126..215	CDD:197477	45/88 (51%)
		EH	307..402	CDD:197477	50/95 (53%)
		SMC_prok_B	<423..>632	CDD:274008	64/261 (25%)
Eps15	XP_038965889.1	EH	13..103	CDD:197477	43/91 (47%)
		EH	121..215	CDD:197477	48/100 (48%)
		EH	253..349	CDD:197477	50/95 (53%)
		COG4372	366..>529	CDD:443500	49/162 (30%)