Protein Alignment Eps-15 and Itsn1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_038944174.1
• Gene: Itsn1 / 29491
• RGDID: 2935
• Length: 1718
• Species: Rattus norvegicus
• Alignment Length: 1133
• Identity: 274/1133 - (24%)
• Similarity: 428/1133 - (37%)
• Gaps: 281/1133 - (24%)

  Fly   116 PVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQD 180
            |...||..: .|:|.|.:|.|::|.|:||.|.:|.:.|::.:.....|.||..:|..||.|||.:
  Rat     5 PTPFGGSLD-IWAITVEERAKHDQQFQSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMN 68

  Fly   181 KDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKP-------------GGAGPPPKPAMPPPP 232
            |||.:|..||.:||.|:...||...:|..|||.:::.             |.||.||..|:.|.|
  Rat    69 KDGRMDQVEFSIAMKLIKLKLQGYQLPPALPPVMKQQPAAISSAPAFGIGGMAGMPPLTAVAPVP 133

  Fly   233 AGA--AMPRAPSGEGFGDGGFVANFPKDIAPPAA------IPPLPVAVPPMTRIPPVGAVS-SQP 288
            .|:  .:..:|.        .|::.|:...||.|      |.|||....|...:|...:.| |.|
  Rat   134 MGSIPVVGMSPP--------LVSSVPQAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190

  Fly   289 LIQTDPLIP-------IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSG 346
            ..|.:..:.       ..||  |.|:|.|..:...::.::|...|....|.::|.:.:.|.::|.
  Rat   191 GSQLNTKLQKAQSFDVASAP--AAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSS 253

  Fly   347 IPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVDLQ 411
            :||..||.||.|.|.:|.||||.|:|.|||..::....|...|.||....:|||.|...:|..:.
  Rat   254 LPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMS 318

  Fly   412 -----------PQE------------VKPTYSNPELEMISKEIEELARER------------RVL 441
                       |:|            :..|:.:.:.|...:...||.:.|            |:.
  Rat   319 VISSSSADQRLPEEPSSEDEQQVEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLA 383

  Fly   442 ETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSL 506
            :.|.|::|...|.:..:.|..|.||:      ||||.||...::|.::.:.::....|  |...|
  Rat   384 QLERAEQERKERERQEQERKRQLELE------KQLEKQRELERQREEERRKEIERREA--AKREL 440

  Fly   507 DISRTNEQVTKIRDQCHMQEVTINEQEG--ELNAKRS----ELQKLKDEE--------------A 551
            :..|..|.....|.:...|.  ..:|||  .|.|:|.    ||:.|.|::              |
  Rat   441 ERQRQLEWERNRRQELLTQR--NKDQEGIVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLA 503

  Fly   552 SLQKEYDSNNR-------ELSKLTNHLQATQLQISSV----RSMVTQLLETQRQM--TDALLICR 603
            :.::|.:|.|:       |::.|...||.:|..:..:    :.:..||.:.|:..  .|:||..:
  Rat   504 TQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILSDQLKQVQQNSLHRDSLLTLK 568

  Fly   604 AAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPF-------EENNSGAANQATNGFGS 661
            .|:|   |:.::..||:  ...||..|....::|  :.|.|       .|.:|....|......:
  Rat   569 RALE---AKELARQQLR--EQLDEVEKETRSKLQ--EIDVFNNQLKELREIHSKQQLQKQRSIEA 626

  Fly   662 DPFSGQPVNKPAISTGFDDSFNMSSGFDSG------FDAFGQSGAGSAFGQTQRDPFGSDAF--- 717
            :....:...:        .|..:....:.|      .|...|........|..|.|...|..
  Rat   627 ERLKQKEQER--------KSLELEKQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKRE 683

  Fly   718 --AANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSP------ALPP 774
              ...|......:|...|..|..|.....|....|...|..:| ||.......|.      ||.|
  Rat   684 DSVKKKEAEERAKPEVQDKQSRLFHPHQEPAKPAQAPWPTTEK-GPLTISAQESAKVVYYRALYP 747

  Fly   775 KKSKVPPPRPAPP--------------RAAQP--TGGFGSGGGGGFADFDDFDNKL--HHIPSAP 821
            .:|:........|              :..:|  .||...|..|.|.  .::..|:  :.||:..
  Rat   748 FESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFP--ANYAEKIPENEIPTPA 810

  Fly   822 SPSATALSPLPPTL-----PAPIPVVSG--SSLLDSFTLFDD--PGQIHKQA--------ASTPN 869
            .|.....|...|.|     |||:||.|.  |:..:::..|..  |...:::.        |:.|:
  Rat   811 KPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSTNEKPETDNWDTWAAQPS 875

  Fly   870 PTPITVPTVHTLLQTSLSTPA-----APSPALASLSTSGSG-SVAGAGADLPSSVTITTAPSLNN 928
               :|||:...|.|.|..|||     :|||.|      |.| .|.|..|
  Rat   876 ---LTVPSAGQLRQRSAFTPATATGSSPSPVL------GQGEKVEGLQA---------------- 915

  Fly   929 QHLSRSNTPLQNQRTADVKLETKAVVSVFDA-----FGEIGTRKAPTP----SLITGP----TDF 980
                ::..|.:.::...:......|::|.:.     |||:..:|...|    .||:||    |..
  Rat   916 ----QALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPVRKSTSI 976

  Fly   981 KDDPFKDYRYEDPFSIK---DPFAE---EGEE-------ELSEGKGADHKRNFAEDFSSGDEI-- 1030
            ...|     .|.|.|:|   .|.|:   .|||       |.||....        .|..||.|
  Rat   977 DTGP-----TEAPSSLKRVASPAAKPAIPGEEFVAMYTYESSEHGDL--------TFQQGDVIVV 1028

  Fly  1031 ---------GSAAKTLSNIVNNNSIKPK 1049
                     |:..:| |.:..:|.::.|
  Rat  1029 TKKDGDWWTGTVGET-SGVFPSNYVRLK 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	36/88 (41%)
		EH	307..402	CDD:197477	33/94 (35%)
		SMC_prok_B	<423..>632	CDD:274008	60/253 (24%)
Itsn1	XP_038944174.1	EH	14..106	CDD:197477	36/91 (40%)
		Atrophin-1	<85..>194	CDD:460830	30/116 (26%)
		EH	217..309	CDD:197477	32/91 (35%)
		Smc	<362..>655	CDD:440809	67/317 (21%)
		MAP7	605..714	CDD:461709	16/116 (14%)
		SH3	741..800	CDD:473055	11/60 (18%)
		INTAP	800..914	CDD:435467	35/122 (29%)
		SH3_Intersectin1_2	914..965	CDD:212922	9/70 (13%)
		SH3	1003..1054	CDD:473055	12/59 (20%)
		SH3_Intersectin1_4	1071..1135	CDD:212926
		SH3_Intersectin1_5	1155..1208	CDD:212928
		RhoGEF	1235..1418	CDD:238091
		PH_13	1437..1579	CDD:465218
		C2_Intersectin	1579..1713	CDD:176021