Protein Alignment Eps-15 and ucp8

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: NP_595633.2
• Gene: ucp8 / 2540786
• PomBaseID: SPBC83.01
• Length: 829
• Species: Schizosaccharomyces pombe
• Alignment Length: 966
• Identity: 201/966 - (20%)
• Similarity: 332/966 - (34%)
• Gaps: 244/966 - (25%)

  Fly    16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLS 80
            ::...:.:.|:....|.......||.|.||...:|::|||..|...||.||:...:...:|:|.:
pombe    14 FDRLLESLHPEQKDLIPGSVIGPFLLKFGLPQKILAKIWDYCDQEDKGSLDRNQVYACFRLISQA 78

  Fly    81 QAGQVASMANI-YLDIANPPKL--------------GELPKTMPSRIQTVPVASGGVANGDWSIG 130
            |.|  |::..: |....:||.|              .|.....|.||   |:      |.|
pombe    79 QRG--ATLQELDYNKAGDPPILPKQAKDDHHIKRSSSETADFTPFRI---PI------NPD---- 128

  Fly   131 VIDRLKYEQLF--------ESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDM 187
              :|.:||:.|        :|..|  |.:|.:..|.:|:.|.|..::|..||:|||....|.|:|
pombe   129 --ERSEYEKEFRENLRGHEDSARP--GCMPSSIAKPILLKSSLHYAVLAQIWNLADSAHVGYLEM 189

  Fly   188 HEFVVAMHLVYQTLQKRTI--PSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGG 250
            :::|:|.|||....|...|  |..||.::.:   :.....|||.
pombe   190 YQYVIARHLVAICKQYNLIHLPRSLPADVIE---SAKSETPAMN--------------------- 230

  Fly   251 FVANFPKDIAPPAAI------PPLPVAVPPMTRIPPVGA-----------VSSQPLIQT-DPLIP 297
              .|..:.:..|:.:      ....::....:::..:.|           .||.|  || ||
pombe   231 --TNIEQGVTQPSLVNTEQLSHQQSISSTKSSKLDEISADNNAQSAVDNKYSSPP--QTIDP--- 288

  Fly   298 IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTN 362
                 .||...::||.|...|.::|.:.|.:..|.:.|.|....|:.|.:....||.||...||.
pombe   289 -----QANIKALITPEDRSNFYQLFSKIDNENKGYIVGGEAVPFFMASHLDSEELARIWDTVDTQ 348

  Fly   363 QSGKLTVEQFALAMWFVERKQRGVDPPHVL--NANMVPPSMRATVAGVDLQPQEVKP------TY 419
            ..|.:..::||:||..::.:..|.....:|  :.|...|:|:..:...|.......|      ..
pombe   349 DRGYIDKDEFAVAMEIIKLRLSGKSLASILAYDDNPTEPTMQQNLVSDDTNASTAVPVAFTNDNV 413

  Fly   420 SNPELEMISKEIEELARERRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQ 484
            ||..|.:...|...........:|...:..|....:|.     .|.|:.|.:..:....|
pombe   414 SNVPLSVADNEPNSTLNLLASSDTAAFEPTAVSLHENP-----SSSLEDLQSAFQNTSFQ----- 468

  Fly   485 KRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQCH-----MQEVTINEQEGELNAKRSELQ 544
               |.:..|...|||       |||:..|..:..:.|..     .|.:.: :..|......|.|.
pombe   469 ---DQVSTQNQANTA-------DISQNTESGSSTQGQMFGIPPTTQSIPL-KMAGFPGGVNSSLT 522

  Fly   545 KLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQ 609
            .:|:|||..:.......|...::...:......||::....:..|.|....|.......|..:.|
pombe   523 DIKEEEAVSENAPQQEERSFEQIKTSIHIAPENISAIEESKSVPLPTSFATTIPGSTSAALDDQQ 587

  Fly   610 NAELVSEYQLKIEPDFDEARKTLTKEVQLPK-DDPFEENNSGAANQATNGFGSDPFSGQPVNK-- 671
            ..|...|     |||......|..::.::.| ::..|....|.....|        ||:.:.:
pombe   588 TTEAPFE-----EPDEPAHEPTEEEQEEMRKLEEKIESTKYGLETIQT--------SGKTIKQRI 639

  Fly   672 -----------------PAISTGFDDSFNMSSGFDSGFDA-FGQSGAG--SAFGQTQRDPFGSDA 716
                             .||........:.|...|..... .|..|.|  .|..:.::.....|:
pombe   640 EQKKTRLMILREELQELDAIKEEAQKQISQSLIADQQLSTQIGSVGMGKKQAVKELRKLQAKIDS 704

  Fly   717 FAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPP 781
            ..|:..                     :|.|.|.|                .|||:.|:.:.. |
pombe   705 IIADSM---------------------SPMGTGAV----------------NSPAIKPQVTPA-P 731

  Fly   782 PRPAPPRAAQPTGGFGSGGGGGFADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSS 846
            |.|||..|.:                       ||.|  |.|..:::||..|  |||:...:.|:
pombe   732 PTPAPTPAVK-----------------------HHPP--PPPVRSSISPSMP--PAPLTHANSST 769

  Fly   847 LLDSFTLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTS 902
            .::..:..:.|.|.::           ::...:.|||..||.......|:.:|..:
pombe   770 PMNYVSQPESPPQSYE-----------SIQNDNELLQELLSMGFPREKAVIALEAT 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	18/65 (28%)
		EH	126..215	CDD:197477	32/98 (33%)
		EH	307..402	CDD:197477	26/96 (27%)
		SMC_prok_B	<423..>632	CDD:274008	40/213 (19%)
ucp8	NP_595633.2	EH	14..80	CDD:238009	18/65 (28%)
		EH	133..204	CDD:238009	25/72 (35%)
		EH	304..370	CDD:238009	19/65 (29%)
		Myosin_tail_1	<638..>702	CDD:460256	8/63 (13%)
		UBA	790..826	CDD:197551	7/25 (28%)