Protein Alignment Eps-15 and si:ch73-140j24.4

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_005171174.1
• Gene: si:ch73-140j24.4 / 101885000
• ZFINID: ZDB-GENE-131120-193
• Length: 1075
• Species: Danio rerio
• Alignment Length: 1160
• Identity: 225/1160 - (19%)
• Similarity: 376/1160 - (32%)
• Gaps: 356/1160 - (30%)

  Fly   323 RQSDL--DKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERKQRG 385
            |.::|  ..:|....:|:|.:..:..|.:.:|....|||.:.|.   |||:..      |||
Zfish    23 RDAELQAQDNGTSEDIEIKGLKDEVHIEEETLQTTKALCRSTQE---TVEKLE------ERK--- 75

  Fly   386 VDPPHVLNANMVPPSMRATVAGVDLQPQEVKPTYSNPELEMISKEIEELARERRVLETEIAQKEA 450
                                            |....|||:| .::::  :||.||
Zfish    76 --------------------------------TLLREELEII-HDLQK--QEREVL--------- 96

  Fly   451 DVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSH----------NTAVLANVS 505
                     ||||.:...|..||:|.:.....|.:.|..||..|::          ..|.|.:|.
Zfish    97 ---------RSLQEQQQELEQTLQQYDTDLCAAAEDLLQLQRDVAYAKTHAESLHVRIAPLQDVF 152

  Fly   506 LDISRTNEQVTK-----IRDQCHMQEVT---INEQEGELNAKRSELQKLKDEEASLQKE------ 556
            .:|.:..:::::     |..:|...|:|   ..:.:||::...||..::..|....::|
Zfish   153 QEIVQVKKKLSELVAGLITGECAASEITDDHCEDLDGEMDVVESECDQVYSENILSEQEGEEMDH 217

  Fly   557 --YDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAA--------MENQNA 611
              .:|...||.|:...|:..:   ||..|..|::..|:.:..|.:.  |:.        ||.::.
Zfish   218 IGQESTVEELDKMQRSLENLK---SSGSSSFTEITLTEVKEEDVMF--RSTTPQSDSSDMEKEDF 277

  Fly   612 ELVSEYQLKIEP-DF--------------DEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGS 661
            |::...|...:. ||              |...|....| |||: |||:              |:
Zfish   278 EIIQPSQATNKQFDFFHPNPFTDGDVFGDDHFPKVDVTE-QLPR-DPFK--------------GT 326

  Fly   662 DPFSGQ------------PVNKPAISTGFDDSFN---MSSGFDSG-FDAFGQSGAGSAFGQ-TQR 709
            |||:..            |........||.|:.:   .|:|.|.| |:|......|:.|.| |:.
Zfish   327 DPFASDSLLVATSDEEHCPDGFTTEDNGFPDTLHYPFQSAGKDYGTFNAPINMPLGADFKQSTEN 391

  Fly   710 DPFGSDAFAANKS--------NA-------------ITPEPGK-------------DDFGSDPFA 740
            ..|.|....:.||        ||             ::||..:             |.|.:||..
Zfish   392 IDFQSTESKSLKSCPDFEVETNATRKQTQEYVQPEDVSPEISEEFVHESGSSSTISDSFEADPIT 456

  Fly   741 -----ALHAPTGQGQVLSPNA----------QKSGPPPRPESPSPA------------------- 771
                 .:....|:..:..||:          ..:|.|..|..|.|.
Zfish   457 LAEVDRVETKAGRSFIKGPNSLCGLQSIIAGSYTGFPLSPCDPEPVSGISDIQKIFEHHIITSEQ 521

  Fly   772 ------------LPPKKSKVPPP---RPAPPRAAQPTGGFGSGGGGGFAD-FDDFDNK------- 813
                        |..|.::...|   ...|...::......|.......: .|.:|.|
Zfish   522 HAEHDKDGSHTELENKNTESVSPDLENTTPGLQSEQLHDINSNASESQPNALDVYDYKYGDMFFF 586

  Fly   814 ----------LH-HIPSAPSPSATALSPLPPTLP----APIPVVSGSSLLDSFTLFDDPGQIHKQ 863
                      || |.|..|.|:..........||    ...|..||...||..:...:..:.|.|
Zfish   587 TVRLDPGSPELHSHGPVCPEPNDVKKDESNDQLPWKDTTLSPEFSGVDELDCCSPKSEDTEEHNQ 651

  Fly   864 AAS---------TPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGA---GADLPS 916
            ..:         .|:......|..:.:|::.......|.|......:....||..:   ..|.|:
Zfish   652 NTNGGQNYFDDRDPDNDANIDPIGNEVLESDCERSEIPIPRFTFDDSDACQSVHNSEWDDEDYPN 716

  Fly   917 S--VTITTAPSLNNQHL----SRSNTPLQNQRTADVKL----------ETKAV----VSVFDAFG 961
            :  .:|...|....|.|    |.::|...:|..||.:|          |..|:    :..||.|.
Zfish   717 APEPSIEDTPKSTVQDLLCMFSNTDTSTTDQVCADEQLLTEFSSQKPSENSAMSQYELQYFDPFS 781

  Fly   962 --------------EIGTRKAPTPSLITG------PTDFKDDPFKDYRYEDPFSIKDPFAEEGEE 1006
                          |:.:.....|.|.:|      ||.|..:|  ..:.:....::||
Zfish   782 PIPAEPVECASDLHEMNSFSHEAPRLDSGYHEVGTPTYFSAEP--TGKIKCSIDLQDP------- 837

  Fly  1007 ELSEGKGADHKRNFAEDFS-SGDEIGSAAKTLSNIVNNNSI------KPKAATPLNNDLLQQFDA 1064
            .|:.||.:|.:.:.|:.|| ...:.|.......|..::..|      .|...|.|||...:|. :
Zfish   838 GLATGKQSDSEIHVADPFSPESVDTGIFDSETENCESSYMITKCQLFSPLVYTDLNNVEEKQM-S 901

  Fly  1065 FNLNSS--PAPSHHSGTS----YHSNSKPSHDSQTALDA------FADFDDFAATLATTGGSGAA 1117
            ||.|.|  ....|.||:.    :...|.||::...|..:      .:|.:....::.....:.|.
Zfish   902 FNNNVSCDILSDHLSGSEPDDCFPFGSCPSNEESYAYSSEGLTQDGSDGEFKHGSMMANASNSAE 966

  Fly  1118 TTATTTGNTKLNNSFFDAFND-NFSVIQSSSVPTGVVRPNDQRAKAFDAFNDNFEDQFKTSPNAN 1181
            ...:...|::::.|..|.|:. ..::....|...|...|:         .|.:.||..|.|..|:
Zfish   967 LMDSVWRNSEMSLSNADMFDPMKNTIFDFDSTDVGSFMPD---------VNQHAEDGEKVSKKAD 1022

  Fly  1182 FAKFDGFEAHNFSSDFGNASFGTTGKEKQNGQVDKKFQSKEPVKDKFAADYSKPE 1236
            ..:.|     .|.|:.......::....|....:..|.|:......:..|:.|.:
Zfish  1023 LVEID-----YFCSELSKMVSSSSSDSVQQSVAEMLFGSEPNTSSFYPWDFEKQQ 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477
		EH	307..402	CDD:197477	17/80 (21%)
		SMC_prok_B	<423..>632	CDD:274008	55/257 (21%)
si:ch73-140j24.4	XP_005171174.1	None