Protein Alignment Eps-15 and eps15l1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_012812304.1
• Gene: eps15l1 / 100158630
• XenbaseID: XB-GENE-959469
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 1072
• Identity: 344/1072 - (32%)
• Similarity: 483/1072 - (45%)
• Gaps: 271/1072 - (25%)

  Fly    16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSLS 80
            ||.|||.:||...|.:....||.|||||.|||::|.:||||:||.|||:|||.||:|||:||:.:
 Frog    17 YETYYKQVDPSYIGRVGPAEAALFLKKSALSDIILGKIWDLADPEGKGYLDKHGFYVALRLVACA 81

  Fly    81 QAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLH 145
            |:|...|::::.:.:. .||..:  .:.|..|...||      .|.|.:.:.::.|::.:|:||.
 Frog    82 QSGHEVSLSSLNVPVP-APKFHD--TSSPLLITPPPV------EGHWGVRIEEKSKFDGIFDSLV 137

  Fly   146 PSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVL 210
            |.||:|.|:|||.|||:||||:.:||.:|:|:|.||||:||..||.|||||||:.|:|..:||||
 Frog   138 PVNGLLSGDKVKPVLMNSKLPLDVLGRVWELSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSVL 202

  Fly   211 PPELRKPGGAGPPPKPAMPP--PPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVP 273
            ||.|.      ||.|....|  |.|.:.:|.:|.             |||
 Frog   203 PPSLI------PPNKRKKTPTFPGAVSVLPSSPP-------------PKD--------------- 233

  Fly   274 PMTRIPPVGAVSSQPLIQTDPLIP--IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGL 336
            .:...|..|::||  |.....|.|  ...|.....:|||...|..||::||.|:|||.||.||||
 Frog   234 SLRSTPSHGSMSS--LNSAGSLSPKHSSKPAQPAVNWVVPLTDKMRFDDIFLQTDLDMDGFVSGL 296

  Fly   337 EVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVLNANMVPPS 400
            ||||||::||:.|..||.||||.||.|:|||..:||||||:|::.| .:|:|||.||:.:|:|||
 Frog   297 EVKDIFMQSGLSQNILAHIWALADTRQTGKLNKDQFALAMYFIQLKVSKGIDPPQVLSPDMIPPS 361

  Fly   401 MRATVAGVDLQPQEVKPTYSNP----------------------------ELEMISKEIEELARE 437
            .|.|       |.:....|..|                            ||:.||:||.:|.||
 Frog   362 ERNT-------PIQTLSGYMTPIGNEMASLTDMRRDSSSSVGSGEFTGVKELDEISQEIAQLQRE 419

  Fly   438 RRVLETEIAQKEADVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLA 502
            :..||.:|.:||..:|.|:.||:.||::||..|:||::||.|:.:||.|||::..|.:....:|.
 Frog   420 KYALEQDIREKEEAIRQKSTEVQDLQNDLDRETSTLQELEAQKQDAQDRLDEMDQQKAKLKDMLN 484

  Fly   503 NVSLDISRTNEQVTKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKL 567
            :|........:.::.::.|...||..:..||.|||..:|||.:|:.||..|::...:...:|..:
 Frog   485 DVRQKCQEEGQMISSLKIQIQSQESDVKAQEEELNRAKSELNRLQQEETQLEQSIQAGRVQLETI 549

  Fly   568 TNHLQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTL 632
            ...|::||.:|:..||.::||.|:|:::            |||::   :|...:..|...:...|
 Frog   550 IKSLKSTQEEINQARSKLSQLQESQQEL------------NQNSD---QYNDALNGDHGSSMNNL 599

  Fly   633 TKEVQLPK----------DDPFEENNSGAAN----------QATNGFGSDPFSGQPVNKPAISTG 677
            :.......          :|||:..:...:|          |..:.|.||||.|.   .|..|..
 Frog   600 SDTESFSSRERTDHSSTIEDPFKNKSHLFSNNNQDIYSDPFQTEDPFTSDPFKGA---DPFKSNP 661

  Fly   678 F-DDSFNMSSGF--DSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKSNAITPEPGKDDF-GSDP 738
            | ||.|..|..|  .:..|.|.:...|        |||.:|.|..|..:::|.....|.| .|||
 Frog   662 FGDDPFKESDPFHAPTSEDPFQKPAKG--------DPFSADPFTKNSVHSMTLPLKSDPFESSDP 718

  Fly   739 FAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPTGGFGSGGGGG 803
            |.                            |..||.||:.       |.....|.|.........
 Frog   719 FI----------------------------SSTLPKKKTD-------PFGTLDPFGSSAFSSNES 748

  Fly   804 FADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQIHKQAASTP 868
            ||||... :|.|..|          .|...|.|.     :|.|        |||   .|....||
 Frog   749 FADFSHM-SKQHQAP----------DPFSATFPG-----TGFS--------DDP---FKSKHDTP 786

  Fly   869 NPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITTAPSLNNQHLSR 933
                        .|....|.|..|.|                    ||..: |....|:..|..:
 Frog   787 ------------ALPPKRSVPPRPKP--------------------PSGKS-TPVSQLSTSHFQK 818

  Fly   934 SNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDYR-YEDPFSIK 997
            |:.|                   |..||             |.|    .|||:..: :.||||.|
 Frog   819 SHDP-------------------FQPFG-------------TEP----GDPFQSRKSFTDPFSGK 847

  Fly   998 DPFAEEGEEELSEGKGADHKRNFAEDFSSGDE 1029
            ||||.....:.|:|..|    .||...|.|:|
 Frog   848 DPFATSQSGKHSKGTSA----GFANFGSFGNE 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	38/65 (58%)
		EH	126..215	CDD:197477	48/88 (55%)
		EH	307..402	CDD:197477	57/95 (60%)
		SMC_prok_B	<423..>632	CDD:274008	67/208 (32%)
eps15l1	XP_012812304.1	EH	17..83	CDD:238009	38/65 (58%)
		EH	119..212	CDD:197477	51/98 (52%)
		EH	267..363	CDD:197477	57/95 (60%)
		COG4372	401..>579	CDD:443500	62/189 (33%)
		CCDC158	<404..902	CDD:464943	166/633 (26%)