Protein Alignment Eps-15 and itsn2

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: XP_004918243.2
• Gene: itsn2 / 100127728
• XenbaseID: XB-GENE-1012238
• Length: 1771
• Species: Xenopus tropicalis
• Alignment Length: 1152
• Identity: 237/1152 - (20%)
• Similarity: 383/1152 - (33%)
• Gaps: 418/1152 - (36%)

  Fly   112 IQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDL 176
            |...|.|..| ....|:|...:|.|:::.|.||.|.||::.|::.:...:.|.||.|:|..||.|
 Frog     6 ISHFPTAMNG-GPSMWAITTEERAKHDKQFASLKPINGLISGDQARSFFIQSGLPSSVLAEIWAL 69

  Fly   177 ADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSVLPPELRKPG----------GAGPPPKPAMPPP 231
            :|.:|||.:|..||.:||.|:...||.:::|.||||.:::|.          |.|..|..:| ||
 Frog    70 SDLNKDGKMDQLEFSIAMKLIKLKLQGQSLPLVLPPVMKQPPVFSPLTSSRYGMGSMPNLSM-PP 133

  Fly   232 PAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPPMTRIPPVGAVSSQP-------- 288
            |..:.:|.||:.              .:...:::||||::.|   .:|.:|:.|:.|
 Frog   134 PMPSLIPFAPTA--------------SLTSMSSLPPLPMSTP---LVPSLGSSSTLPNGTSTALL 181

  Fly   289 -----------------------------LIQTDPLIPI---------------GAPVMANADWV 309
                                         :.:|..||.:               .:|.....||.
 Frog   182 SSFPVPLSSSTLPHNSSINLLGGGFSSTTMQKTQSLIDLASSSSNSSSTTSLTGNSPKTTYLDWA 246

  Fly   310 VTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFAL 374
            |..|...::.:.|...|....|.::|.:||:..::|.:....||.||.|.|.::.|||..::|.|
 Frog   247 VPQASRLKYRQKFNSLDKCMTGYLTGSQVKNALVQSSLSHTQLATIWNLADIDKDGKLKADEFIL 311

  Fly   375 AMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVDLQP------------QEVKP------TYSN 421
            ||:..:..:.|...|..|..::|||:.|:.|:.....|            :|..|      |:..
 Frog   312 AMYLTDMAKAGQPLPLTLPPDLVPPAFRSNVSITASDPINGTLPLYHQMHEEEPPQKKTAGTFEE 376

  Fly   422 PELEMISKEIEELARERRVL--------------------------------------------- 441
            ...|.|.|...||.:.|:|:
 Frog   377 KRKENIEKGNMELEKRRQVILEQQQREAERKAQKQREEQERRERERQEQERKKLLEQERRMERQR 441

  Fly   442 ----------ETEIAQKEA---------------------------------------------- 450
                      ..||.::||
 Frog   442 ELERQREEEKRKEIERREAAKQELERQRQQELERIRRQELFNQRNREQEEIMKLKSKKKSLQLEL 506

  Fly   451 ---------------DVR----IKNGEVRSLQSELDTLTATLKQLENQRGEAQKRL-------DD 489
                           |||    :|..|:.:|..:.|.....:|||:.:..|.|.:|       ..
 Frog   507 EALEDKHQQITSRVQDVRGKKQLKRTELETLDRKCDAGIMEIKQLQQELQEYQNKLSILLPEKQF 571

  Fly   490 LQAQVSHNTAVLANVSLDISRTNEQ------------VTKIRDQCH---------MQEV-TINEQ 532
            |..:::...||::|   |.|.|..|            ..::|:|..         :||: :.|.|
 Frog   572 LNEKINQMQAVISN---DKSGTGFQGFHKKVSEKDGLCQRLREQLEALEKETSSKLQEMDSFNNQ 633

  Fly   533 EGELNAKRS-------ELQKLK--------------------DEEASLQKEYDSNNRELSKLTNH 570
            ..||....|       :|||:|                    :|||:.:.:.:..|..|..|...
 Frog   634 LKELRGSYSKQQSALHQLQKIKQEKLREAEQKRAEQAQKKQEEEEAARRAKQEKENLWLENLKKE 698

  Fly   571 LQATQLQISSVRSMVTQLLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKE 635
            .:..|.::...|....:|||.|:...:|....|.|.:    .|..|.:.:.|.:.::.:|...:|
 Frog   699 EEEKQQRLEDERRREQKLLEKQKAEEEATARQREAQQ----RLAEEKKRQAEREEEQRKKQQEEE 759

  Fly   636 ----VQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKPAIS-TGFDDSF----------NMS 685
                .||.||   .|..|.|.::......|   :|:..::..|| ...|:.|          |.|
 Frog   760 KRRQAQLKKD---LEEKSKAEDEERRRKES---AGRKDSEKRISKLSLDEKFADKLKNIGGRNAS 818

  Fly   686 SGFDSGFDA-------FGQSGAGSAFGQTQRDPF---GSDAFAANKSNAI------TPEPG---- 730
            |  :.|.:|       ..:|.|.:....|...||   .:|..:.|..:.:      ..|||
 Frog   819 S--ERGREANTTSVSDNRRSSAAAFVNYTALYPFEARNADELSFNAGDILQVDEKNIGEPGWLYG 881

  Fly   731 --KDDFGSDPFAALHAPTGQGQVLSPNAQKSGPPPRPESPSPALPPKKSKVPPPRPAPPRAAQPT 793
              :.:.|..|              |..|:|:.....|.||..||.|....|....||.|.....:
 Frog   882 CLRGNVGWFP--------------SNYAEKATEIEAPLSPKKALLPPTLSVSTSSPAKPLLTSKS 932

  Fly   794 GGFGSGGGGGFADFDDFDNKLHHIPSA---------PSPSATALSPLPPTLP------APIPVVS 843
            .             .:.|.:..::|.:         ...||...:..|.|:.      .|...|.
 Frog   933 S-------------SELDTEYQNLPFSSLNVNNTTWQKTSAFTRTVSPGTISPMHGQGQPGESVK 984

  Fly   844 GSSLL---------------DSFTLFDDP-----GQIHKQA---------------ASTPNPTPI 873
            ..:|.               |:..:.:..     |::..|.               |.||.|.|:
 Frog   985 AQALCSWTAKKDNHLNFSKNDTIVVLEQQENWWFGEVRGQKGWFPKSYVKILPGTDAKTPEPEPV 1049

  Fly   874 TVPTVHTLLQTSLSTPAAPSP------ALASLSTSGSGSVAGAGADL 914
            ....        ...|.|||.      ||.|.|:|..|.:.....||
 Frog  1050 YAAV--------KKKPVAPSAAGEEYVALYSYSSSEPGDLIFNEGDL 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009
		EH	126..215	CDD:197477	36/88 (41%)
		EH	307..402	CDD:197477	30/94 (32%)
		SMC_prok_B	<423..>632	CDD:274008	64/384 (17%)
itsn2	XP_004918243.2	EH	19..111	CDD:197477	36/91 (40%)
		Atrophin-1	<92..>194	CDD:460830	27/119 (23%)
		EH	244..323	CDD:197477	24/78 (31%)
		PTZ00121	<351..795	CDD:173412	77/456 (17%)
		Smc	<607..>870	CDD:440809	58/274 (21%)
		SH3_Intersectin2_1	841..897	CDD:212921	12/69 (17%)
		SH3_Intersectin2_2	984..1035	CDD:212923	4/50 (8%)
		SH3_Intersectin2_3	1066..1117	CDD:212925	8/23 (35%)
		SH3_Intersectin2_4	1138..1196	CDD:212927
		SH3_Intersectin2_5	1211..1264	CDD:212929
		RhoGEF	1295..1474	CDD:459876
		PH_13	1493..1635	CDD:465218
		C2_Intersectin	1635..1769	CDD:176021