DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP20

DIOPT Version :10

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_004762.2 Gene:MMP20 / 9313 HGNCID:7167 Length:483 Species:Homo sapiens


Alignment Length:521 Identity:185/521 - (35%)
Similarity:250/521 - (47%) Gaps:81/521 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SVFIVVGTLFSIMAAAQSAPVSTTTQ-----AEIYLS---------QFGYLPASARNPASSGLHD 57
            :||:::...||..|.:..|....|.:     |:.||.         |.|.:.|...|        
Human    10 AVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSN-------- 66

  Fly    58 QRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRD----RVGTGDSRSKRYALQGSRWRV 118
              :.:..|:|.|:|.||.:||:||..||.::..|||||.|    |:..|:          .:|:.
Human    67 --SMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGE----------PKWKK 119

  Fly   119 KNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDG 183
            ..|||:||||...:..|:||..:..|...||....|:|.|..||...|.|.|...:|||...|||
Human   120 NTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDG 184

  Fly   184 QGGTLAHAFFP--VFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFY 246
            ..|||||||.|  ..|||.|||:||.||:|: .|.|||.||||||||:|||:||...||||.|.|
Human   185 PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLAHSTDPSALMYPTY 248

  Fly   247 RGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVY---PATTQRPYSPPKVPLDDSICKDSKVDT 307
            :...|. |.|.:||...||:|||       |..|:   |.....|:..|.:|   .:|..|....
Human   249 KYKNPYGFHLPKDDVKGIQALYG-------PRKVFLGKPTLPHAPHHKPSIP---DLCDSSSSFD 303

  Fly   308 LFNSAQGETYAFKGDKYYKLTTDSVEEGY-PQLISKGWPGLPGNIDAAF-TYKNGKTYFFKGTQY 370
            .......|...|| |:.:......:..|. |..|:..:|.|..|:|||: ..:.|..|||||..|
Human   304 AVTMLGKELLLFK-DRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHY 367

  Fly   371 WRYQGRQMDGVYPKEISEGFTGIPDH---LDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASY 432
            |..:|.||.|. |:.|.:  .|.|.|   :|||:......|..||.|.:::.:|..|| .::..|
Human   368 WITRGFQMQGP-PRTIYD--FGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKR-KMEKDY 428

  Fly   433 PKPI-SNWEGVPNNLDAALKYTNGYTYFFKGDKYYRF----HDARFAVDSATPPFPRPTAHWWFG 492
            ||.. ..:.||...:|||:: .|||.|||.|.|.|::    .|....|.|::          |.|
Human   429 PKNTEEEFSGVNGQIDAAVE-LNGYIYFFSGPKTYKYDTEKEDVVSVVKSSS----------WIG 482

  Fly   493 C 493
            |
Human   483 C 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:460223 19/69 (28%)
Peptidase_M10 115..268 CDD:425668 78/155 (50%)
HX 298..493 CDD:238046 63/204 (31%)
MMP20NP_004762.2 PG_binding_1 35..95 CDD:460223 19/69 (28%)
Cysteine switch. /evidence=ECO:0000250 98..105 5/6 (83%)
Peptidase_M10 116..271 CDD:425668 78/155 (50%)
HX 293..483 CDD:238046 64/208 (31%)
Hemopexin 1 293..343 11/53 (21%)
Hemopexin 2 344..389 19/47 (40%)
Hemopexin 3 391..439 13/48 (27%)
Hemopexin 4 440..483 16/53 (30%)

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