Protein Alignment Mmp1 and Mmp1a

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_114395.1
• Gene: Mmp1a / 83995
• MGIID: 1933846
• Length: 464
• Species: Mus musculus
• Alignment Length: 479
• Identity: 157/479 - (32%)
• Similarity: 216/479 - (45%)
• Gaps: 70/479 - (14%)

  Fly    36 YLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVG 100
            ||..:..|   .:|..:..::.:......:.:.|...||.:||..|.||::.|..|||||.|
Mouse    35 YLENYYNL---GKNMQAKNVNGKEMMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPD--- 93

  Fly   101 TGDSRSKRYAL--QGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGP 163
                 ...||:  ...||...:|||.|..|...|.:..|:..|.|||.|||:.|.|||.|.....
Mouse    94 -----VAPYAITHNNPRWTKTHLTYSILNYTPYLPKAVVEDAIARAFRVWSDVTPLTFQRVFEEE 153

  Fly   164 VHIEIKFVESEHGDGDAFDGQGGTLAHAF--FPVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEF 226
            ..|.:.|...:|||.:.|||....|||.|  .|..|||.|:|..|.|| .|....|||.|.|||.
Mouse   154 GDIVLSFHRGDHGDNNPFDGPNYKLAHTFQPGPGLGGDVHYDLDETWT-NSSENFNLFYVTAHEL 217

  Fly   227 GHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPP 291
            ||||||:||....|||.|.|..:...|.|::||...||.|||...|.::||.   |||..|
Mouse   218 GHSLGLTHSSDIGALMFPSYTWYTEDFVLNQDDINRIQDLYGPSPNPIQPTG---ATTPHP---- 275

  Fly   292 KVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFT 356
                    |..........:.:||.:.||| ::|......:.|....||...||.||..:|||:.
Mouse   276 --------CNGDLTFDAITTFRGEVFFFKG-RFYIRVNRFMPEPELNLIGILWPNLPVKLDAAYE 331

  Fly   357 YKN-GKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPD---HLDAAMVWGGNGKIYFFKGSKF 417
            ... .:..:|||::.|..|.:.:...:|::| ..|.|.|.   |:|||:.....||.|||....:
Mouse   332 ASMIDQVRYFKGSKVWAVQEQSVLRGFPRDI-HSFFGFPSNVTHIDAAVCEEETGKTYFFVDHMY 395

  Fly   418 WRFDPAKRPPVKASYPK-PISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDA---RFAV--- 475
            ||:| .....:...||: ...::.|:.:.:|         ..|.||:.:|.||.:   ||.:
Mouse   396 WRYD-ENTQSMDPGYPRLTAEDFPGIDDKVD---------DVFQKGENFYFFHQSVQHRFNLQIR 450

  Fly   476 ------DSATPPFPRPTAHWWFGC 493
                  ||:|          ||.|
Mouse   451 RVDDSRDSST----------WFNC 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	12/51 (24%)
		Peptidase_M10	115..268	CDD:425668	70/154 (45%)
		HX	298..493	CDD:238046	56/211 (27%)
Mmp1a	NP_114395.1	PG_binding_1	26..84	CDD:460223	12/51 (24%)
		Cysteine switch. /evidence=ECO:0000250	87..94		6/14 (43%)
		Metalloprotease	95..274		80/182 (44%)
		Peptidase_M10	105..259	CDD:425668	70/154 (45%)
		HX	273..464	CDD:238046	57/224 (25%)
		Hemopexin 1	273..322		13/61 (21%)
		Hemopexin 2	323..369		13/46 (28%)
		Hemopexin 3	372..420		14/48 (29%)
		Hemopexin 4	421..464		14/61 (23%)