Protein Alignment Mmp1 and Mmp2

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_112316.2
• Gene: Mmp2 / 81686
• RGDID: 621316
• Length: 662
• Species: Rattus norvegicus
• Alignment Length: 684
• Identity: 177/684 - (25%)
• Similarity: 242/684 - (35%)
• Gaps: 238/684 - (34%)

  Fly    11 VVGTLFSIMAAAQSAP---------VSTTTQAEI---YLSQFGYLPASARNPASSGLHDQRTWV- 62
            |:..|..::..|.:||         ||..|..|:   ||:.|...|..:.|          .:|
  Rat    16 VLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCN----------LFVL 70

  Fly    63 -SAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKIS 126
             ..:::.|.|.||..||:||..|::.|..|||      |..|..:..:..:..:|....:||:|.
  Rat    71 KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC------GNPDVANYNFFPRKPKWDKNQITYRII 129

  Fly   127 KYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHA 191
            .|...|....||....||..|||:.|.|.|:|...|...|.|.|...|||||..|||:.|.||||
  Rat   130 GYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHA 194

  Fly   192 FFP--VFGGDAHFDDAELWTIGS------------------------------------------ 212
            |.|  ..|||:||||.||||:|.
  Rat   195 FAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWC 259

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
  Rat   260 STTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYD 324

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
  Rat   325 RDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGF 389

  Fly   213 --PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLR 275
              .:|.:||.||||||||::||.||....|||||.|. :...|:|..||...||.|||...:...
  Rat   390 CPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYT-YTKNFRLSNDDIKGIQELYGPSPDADT 453

  Fly   276 PTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLI 340
            .|...|..|..|.:|       .|||...|.......:||.:.||....::..|...:...|.|:
  Rat   454 DTGTGPTPTLGPVTP-------EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLV 511

  Fly   341 SKGWPGLPGNIDAAF-TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP---DHLDAAM 401
            :..||.||..|||.: ..:..|..||.|.:||.|....::..|||.::.  .|:|   ..:|||.
  Rat   512 ATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQQVDAAF 574

  Fly   402 VWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NWEGVPNNLDAALKYT-NGYTYFFKGDK 464
            .|..|.|.|.|.|.||||::..|: .:...:||.|: :|..:|:||||.:... .|::|||||..
  Rat   575 NWSKNKKTYIFSGDKFWRYNEVKK-KMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAY 638

  Fly   465 YYRFHD-----ARFAVDSATPPFPRPTAHWWFGC 493
            |.:..:     .:|....:.          |.||
  Rat   639 YLKLENQSLKSVKFGSIKSD----------WLGC 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	16/60 (27%)
		Peptidase_M10	115..268	CDD:425668	76/328 (23%)
		HX	298..493	CDD:238046	62/205 (30%)
Mmp2	NP_112316.2	PG_binding_1	<70..97	CDD:460223	9/26 (35%)
		Cysteine switch. /evidence=ECO:0000250	100..107		4/12 (33%)
		Collagenase-like 1	110..221		48/110 (44%)
		Peptidase_M10	118..446	CDD:425668	76/328 (23%)
		Collagen-binding	222..396		1/173 (1%)
		FN2	226..274	CDD:128373	0/47 (0%)
		FN2	284..332	CDD:128373	0/47 (0%)
		FN2	342..390	CDD:128373	0/47 (0%)
		Collagenase-like 2	397..467		33/70 (47%)
		Required for inhibitor TIMP2 binding. /evidence=ECO:0000250	414..662		83/268 (31%)
		HX	468..662	CDD:238046	63/213 (30%)