Protein Alignment Mmp1 and MMP19

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_002420.1
• Gene: MMP19 / 4327
• HGNCID: 7165
• Length: 508
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 200/547 - (36%)
• Similarity: 275/547 - (50%)
• Gaps: 78/547 - (14%)

  Fly     3 NCQSSVFIVVGTLF------SIMAAAQSAPVSTTTQAEIYLSQFGYL--PASARN---PASSGLH 56
            |||.   :.:|.|.      .::..|:.|||.       ||||:|||  |....|   |...
Human     2 NCQQ---LWLGFLLPMTVSGRVLGLAEVAPVD-------YLSQYGYLQKPLEGSNNFKPEDI--- 53

  Fly    57 DQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNL 121
                 ..|:..||..:.|.::|:||..|...|..||||:.|..   :.::.:|.|.| |||.|:|
Human    54 -----TEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPF---NQKTLKYLLLG-RWRKKHL 109

  Fly   122 TYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGD-----GDAF 181
            |::|...|..|......|.:.:||..||....|||....:|...|.:.|    ||.     .:.|
Human   110 TFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSF----HGRQSSYCSNTF 170

  Fly   182 DGQGGTLAHAFFPVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFY 246
            ||.|..||||..|.. |..|||:.|.||.|:.||.||..:||||.||:|||.||..|.|||||.|
Human   171 DGPGRVLAHADIPEL-GSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVY 234

  Fly   247 RGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKD---SKVDTL 308
            .|:.|.|||..||.|.||:|||:|:..:|...  ...|:.|..|| ||.:.|...|   |::|.:
Human   235 EGYRPHFKLHPDDVAGIQALYGKKSPVIRDEE--EEETELPTVPP-VPTEPSPMPDPCSSELDAM 296

  Fly   309 FNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAA-FTYKNGKTYFFKGTQYWR 372
            ....:|:|||||||  |..|......|....:|..|.|||||:||| ::.:....:||||.:.||
Human   297 MLGPRGKTYAFKGD--YVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWR 359

  Fly   373 YQGRQMDGVYPKEISEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS 437
            |...:|...:||:::.    :..:||||:.|..|.|::.||||.:|::|...|... :||||||.
Human   360 YINFKMSPGFPKKLNR----VEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDF-SSYPKPIK 419

  Fly   438 N-WEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCK------- 494
            . :.||||...||:.:.:|..|||||..|:|.:. :..|:..   :||..:|.|..|:
Human   420 GLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQ-QLRVEKG---YPRNISHNWMHCRPRTIDTT 480

  Fly   495 -----NTPSSTG----NIVEGSDNEFE 512
                 .|||.||    ..:..::..||
Human   481 PSGGNTTPSGTGITLDTTLSATETTFE 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	18/60 (30%)
		Peptidase_M10	115..268	CDD:425668	72/157 (46%)
		HX	298..493	CDD:238046	74/199 (37%)
MMP19	NP_002420.1	PG_binding_1	31..80	CDD:460223	18/56 (32%)
		Cysteine switch. /evidence=ECO:0000250	83..90		4/6 (67%)
		ZnMc_MMP	103..256	CDD:239805	72/157 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..288		8/28 (29%)
		HX	286..472	CDD:238046	73/196 (37%)
		Hemopexin 1	286..333		16/48 (33%)
		Hemopexin 2	334..380		16/49 (33%)
		Hemopexin 3	381..425		19/44 (43%)
		Hemopexin 4	426..472		17/49 (35%)