Protein Alignment Mmp1 and MMP17

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_057239.4
• Gene: MMP17 / 4326
• HGNCID: 7163
• Length: 603
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 178/539 - (33%)
• Similarity: 273/539 - (50%)
• Gaps: 66/539 - (12%)

  Fly     8 VFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFA 72
            :.:.:||.....|.|.:......:....:||:|||||.:  :|.:..|..|.....||...|.|.
Human    27 LLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPA--DPTTGQLQTQEELSKAITAMQQFG 89

  Fly    73 GLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDV 137
            ||..||.||..|:.||..|||.:.|......:|.:|.|...::|..:||::::..:|:
Human    90 GLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPR------- 147

  Fly   138 DAEIGR---------AFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFF 193
            |:.:|.         |..|||:...|.|.........|:|.|.:::|.||..|||.|||:|||||
Human   148 DSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFF 212

  Fly   194 PVF---GGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV- 252
            |..   .||.||||.|.||..|  ..|.:||.||.|||||::||||...:.::|.|:|:|  ||
Human   213 PGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQG--PVG 275

  Fly   253 ----FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKV--PLDDSICKDSKVD----- 306
                :.|..:||..:..|||.:      .:|.|  |.:|..||.:  |.|:......:.|
Human   276 DPLRYGLPYEDKVRVWQLYGVR------ESVSP--TAQPEEPPLLPEPPDNRSSAPPRKDVPHRC 332

  Fly   307 -TLFNSA---QGETYAFKGDKYYKLTTD----SVEEGYPQLISKGWPGLP---GNIDAAF-TYKN 359
             |.|::.   :||.:.|||..:::||.|    |::   |..:.:.|.|||   .::||.: ...:
Human   333 STHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQ---PAQMHRFWRGLPLHLDSVDAVYERTSD 394

  Fly   360 GKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAK 424
            .|..||||.:||.::...::..||:.:|: |:..|..:|||..|..|.:.||||...:||:|...
Human   395 HKIVFFKGDRYWVFKDNNVEEGYPRPVSD-FSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHT 458

  Fly   425 RPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW 489
            | .:...||.....|.|||:.||.|:::::|.:|||:|.:|::..|....|   .|.:|:.||..
Human   459 R-HMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEV---APGYPQSTARD 519

  Fly   490 WFGCKNTPSSTGNIVEGSD 508
            |..|.:: .:.|::..|.|
Human   520 WLVCGDS-QADGSVAAGVD 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	21/55 (38%)
		Peptidase_M10	115..268	CDD:425668	64/171 (37%)
		HX	298..493	CDD:238046	66/211 (31%)
MMP17	NP_057239.4	PG_binding_1	54..105	CDD:460223	21/52 (40%)
		Cysteine switch. /evidence=ECO:0000250	108..115		3/6 (50%)
		ZnMc_MMP	132..295	CDD:239805	64/171 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..329		8/29 (28%)
		HX	329..523	CDD:238046	65/201 (32%)
		Hemopexin 1	333..378		13/47 (28%)
		Hemopexin 2	382..427		13/45 (29%)
		Hemopexin 3	428..475		17/47 (36%)
		Hemopexin 4	476..523		17/49 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..571		1/1 (100%)