DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP15

DIOPT Version :10

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_002419.1 Gene:MMP15 / 4324 HGNCID:7161 Length:669 Species:Homo sapiens


Alignment Length:617 Identity:212/617 - (34%)
Similarity:296/617 - (47%) Gaps:90/617 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFA 72
            :.:::|.| .:..||:.|.|    .||.:|..:||||..:|:  .|.:...:...||:.|.|.|.
Human    33 LLVLLGCL-GLGVAAEDAEV----HAENWLRLYGYLPQPSRH--MSTMRSAQILASALAEMQRFY 90

  Fly    73 GLNITGELDAETMKLMSLPRCGVRDRVGTG-----DSRSKRYALQGSRWRVKNLTYKISKYPKRL 132
            |:.:||.||.||.:.|..|||||.|:.|..     ..|.|||||.|.:|...:||:.|..|.::|
Human    91 GIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKL 155

  Fly   133 KRVDVDAEIGRAFAVWSEDTDLTFTR--------KTSGPVHIEIKFVESEHGDGDAFDGQGGTLA 189
            ........:.|||.||.:.|.|.|..        :......|.:.|....|||...|||.||.||
Human   156 GWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLA 220

  Fly   190 HAFF--PVFGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFE 250
            ||:|  |..|||.|||..|.||..|.  .|.|||.||.||.||:|||.||...:|:|||||: ::
Human   221 HAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQ-WK 284

  Fly   251 PV--FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATT--------QRPYSPPKVP----------- 294
            .|  |||.|||...||.|||....|.:||...|..|        .||..||:.|           
Human   285 DVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPK 349

  Fly   295 ---------------LDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGW 344
                           ...:|| |...||: ...:||.:.|||..::::..:.|.:.||..|...|
Human   350 PGPPVQPRATERPDQYGPNIC-DGDFDTV-AMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFW 412

  Fly   345 PGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGK 408
            .||||:|.||:..::|:..||||.:||.::...::..||:.::....||| |.:|.|:.|...|.
Human   413 RGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGH 477

  Fly   409 IYFFKGSKFWRF-------DPAKRPPVKASYPKPISNWEGVPNNLDAA-LKYTNGYTYFFKGDKY 465
            .:||:..::|||       ||        .||||||.|:|:|.:...| |.....||||:||.||
Human   478 TFFFQEDRYWRFNEETQRGDP--------GYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKY 534

  Fly   466 YRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNIVEGSDNEFEQH-SMIPHADDGNGD--- 526
            ::|.:.|..::   |.:|:.....:.||:..........:.:...|..| ...|.||...||   
Human   535 WKFDNERLRME---PGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGD 596

  Fly   527 -DFDAAVGDHQSNDEPIVPEVAE--RTGNGAM 555
             |.|...|.::.....:|.::.|  ||.|..|
Human   597 GDGDFGAGVNKDGGSRVVVQMEEVARTVNVVM 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:460223 21/55 (38%)
Peptidase_M10 115..268 CDD:425668 71/166 (43%)
HX 298..493 CDD:238046 69/203 (34%)
MMP15NP_002419.1 PG_binding_1 53..106 CDD:460223 21/54 (39%)
Cysteine switch. /evidence=ECO:0000250 109..116 5/6 (83%)
Peptidase_M10 138..304 CDD:425668 71/166 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..370 14/69 (20%)
HX 367..559 CDD:238046 69/204 (34%)
Hemopexin 1 367..415 15/49 (31%)
Hemopexin 2 416..461 14/44 (32%)
Hemopexin 3 463..511 20/55 (36%)
Hemopexin 4 512..559 14/49 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..593 5/18 (28%)
DUF3377 <643..669 CDD:463374
Blue background indicates that the domain is not in the aligned region.

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