Protein Alignment Mmp1 and MMP11

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_005931.2
• Gene: MMP11 / 4320
• HGNCID: 7157
• Length: 488
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 184/488 - (37%)
• Similarity: 244/488 - (50%)
• Gaps: 60/488 - (12%)

  Fly    43 LPASARNPASSGLHDQR----TWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVG--T 101
            |.|.|..|.:..||.:|    .|.:|:.  .|.|....|.|.......|.. |||||.|...  :
Human    29 LLARALPPDAHHLHAERRGPQPWHAALP--SSPAPAPATQEAPRPASSLRP-PRCGVPDPSDGLS 90

  Fly   102 GDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHI 166
            ..:|.||:.|.|.||...:|||:|.::|.:|.:..|...:..|..|||:.|.||||....|...|
Human    91 ARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADI 155

  Fly   167 EIKFVESEHGDGDAFDGQGGTLAHAFFPVF--GGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHS 229
            .|.|....|||...|||.||.|||||||..  .||.|||..|.||||..:||:|.|||||||||.
Human   156 MIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHV 220

  Fly   230 LGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGR------------------KTNQLRP 276
            |||.|:..:.|||:.||. |.....|..||...:|.|||:                  .||::.|
Human   221 LGLQHTTAAKALMSAFYT-FRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAP 284

  Fly   277 TNVYPATTQRPYSPPKVPLDDSICKDS--KVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQL 339
            .        .|.:||      ..|:.|  .|.|:    :||.:.||....::|....::.|||.|
Human   285 L--------EPDAPP------DACEASFDAVSTI----RGELFFFKAGFVWRLRGGQLQPGYPAL 331

  Fly   340 ISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISE-GFTGIPDHLDAAMVW 403
            .|:.|.|||..:||||....|..:||:|.|||.|.| :...:.|..::| |....|.|  ||:||
Human   332 ASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDG-EKPVLGPAPLTELGLVRFPVH--AALVW 393

  Fly   404 G-GNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYR 467
            | ...|||||:|..:|||.|:.| .|.:..|:..::|.|||:.:|||.:..:||.||.:|..|::
Human   394 GPEKNKIYFFRGRDYWRFHPSTR-RVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWK 457

  Fly   468 FHDARFAVDSATPPFPRPTAHWWFGCKNTPSST 500
            |...:.   .|...|||.....:|||.. |::|
Human   458 FDPVKV---KALEGFPRLVGPDFFGCAE-PANT 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	13/48 (27%)
		Peptidase_M10	115..268	CDD:425668	74/154 (48%)
		HX	298..493	CDD:238046	73/198 (37%)
MMP11	NP_005931.2	PRK12323	<2..>86	CDD:481241	20/59 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..93		16/54 (30%)
		Cysteine switch. /evidence=ECO:0000250	78..85		5/6 (83%)
		Peptidase_M10	104..258	CDD:425668	74/154 (48%)
		HX	291..480	CDD:238046	74/205 (36%)
		Hemopexin 1	291..339		16/57 (28%)
		Hemopexin 2	340..382		16/42 (38%)
		Hemopexin 3	384..432		21/50 (42%)
		Hemopexin 4	433..480		16/49 (33%)