Protein Alignment Mmp1 and Mmp13

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_032633.1
• Gene: Mmp13 / 17386
• MGIID: 1340026
• Length: 472
• Species: Mus musculus
• Alignment Length: 449
• Identity: 170/449 - (37%)
• Similarity: 228/449 - (50%)
• Gaps: 48/449 - (10%)

  Fly    33 AEIYLSQFGYLPASARNPASSGLHDQRTWVSAIE---EFQSFAGLNITGELDAETMKLMSLPRCG 94
            ||.||..: |.||:.     :|:..:.|..|.::   |.|||.||.:||:||..|:.:|..||||
Mouse    40 AEHYLKSY-YHPATL-----AGILKKSTVTSTVDRLREMQSFFGLEVTGKLDDPTLDIMRKPRCG 98

  Fly    95 VRDRVGTGDSRSKRYAL--QGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFT 157
            |.| ||       .|.:  :..:|...||||:|..|...:...:|:....:||.|||:.|.|.||
Mouse    99 VPD-VG-------EYNVFPRTLKWSQTNLTYRIVNYTPDMSHSEVEKAFRKAFKVWSDVTPLNFT 155

  Fly   158 RKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAF--FPVFGGDAHFDDAELWTIGSPRGTNLFQ 220
            |...|...|.|.|...||||...|||..|.|||||  .|.:||||||||.|.|| .|.:|.|||.
Mouse   156 RIYDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT-SSSKGYNLFI 219

  Fly   221 VAAHEFGHSLGLSHSDQSSALMAPF--YRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPAT 283
            |||||.||||||.||....|||.|.  |.| :..|.|.:||...||.|||.......|
Mouse   220 VAAHELGHSLGLDHSKDPGALMFPIYTYTG-KSHFMLPDDDVQGIQFLYGPGDEDPNP------- 276

  Fly   284 TQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVE-EGYPQLISKGWPGL 347
             :.|.:|.|  .|.::..|:     ..|.:|||..||...:::|....|| |.:  |....||.|
Mouse   277 -KHPKTPEK--CDPALSLDA-----ITSLRGETMIFKDRFFWRLHPQQVEAELF--LTKSFWPEL 331

  Fly   348 PGNIDAAFTYKNGKTYF-FKGTQYWRYQGRQMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIY 410
            |.::|||:.:.:....| |:|.::|...|..:...||::||: ||......|.||:.:...||..
Mouse   332 PNHVDAAYEHPSRDLMFIFRGRKFWALNGYDILEGYPRKISDLGFPKEVKRLSAAVHFENTGKTL 396

  Fly   411 FFKGSKFWRFDPAKRPPVKASYPKPI-SNWEGVPNNLDAALKYTNGYTYFFKGDKYYRF 468
            ||..:..|.:|...:...| .||:.| ..:.|:.|.:||..: .|||.|||.|...:.:
Mouse   397 FFSENHVWSYDDVNQTMDK-DYPRLIEEEFPGIGNKVDAVYE-KNGYIYFFNGPIQFEY 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	21/57 (37%)
		Peptidase_M10	115..268	CDD:425668	78/156 (50%)
		HX	298..493	CDD:238046	54/175 (31%)
Mmp13	NP_032633.1	PG_binding_1	33..92	CDD:460223	21/57 (37%)
		Cysteine switch. /evidence=ECO:0000250	95..102		6/7 (86%)
		Peptidase_M10	113..268	CDD:425668	78/156 (50%)
		Interaction with TIMP2. /evidence=ECO:0000250	177..247		43/70 (61%)
		Interaction with collagen. /evidence=ECO:0000250	269..472		59/204 (29%)
		HX	282..472	CDD:238046	57/183 (31%)