Protein Alignment Mmp1 and Mmp10

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_598198.2
• Gene: Mmp10 / 117061
• RGDID: 620192
• Length: 476
• Species: Rattus norvegicus
• Alignment Length: 450
• Identity: 174/450 - (38%)
• Similarity: 236/450 - (52%)
• Gaps: 42/450 - (9%)

  Fly    57 DQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGS-RWRVKN 120
            |....|..|||.|.|.||.:||:||:.|:::|..|||||.| || |.|     ...|| :||..:
  Rat    56 DSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPD-VG-GFS-----TFPGSPKWRKNH 113

  Fly   121 LTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQG 185
            ::|:|..|...|.|..||:.|.||..||.|.|.|||:|.:.|...|.|.|...||||...|||.|
  Rat   114 ISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGVG 178

  Fly   186 GTLAHAF--FPVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYR- 247
            .:||||:  .|.|.|||||||.|.|::| |.|||||.|||||.||||||.||:...:||.|.||
  Rat   179 QSLAHAYPPGPGFYGDAHFDDDEKWSLG-PSGTNLFLVAAHELGHSLGLFHSNNKESLMYPVYRF 242

  Fly   248 -GFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNS 311
             ..:...:|.:||...||||||.:.:........|:.:.:|.:|  |..|.::..|:     ...
  Rat   243 STSQANIRLSQDDIEGIQSLYGARPSSDATVVPVPSVSPKPETP--VKCDPALSFDA-----VTM 300

  Fly   312 AQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQYWRYQG 375
            .:||...||...:::.|..:.|..: .|||..||.||..:|||:...| .:...|||:|:|..:|
  Rat   301 LRGEFLFFKDRHFWRRTQWNPEPEF-HLISAFWPSLPSGLDAAYEANNKDRVLIFKGSQFWAVRG 364

  Fly   376 RQMDGVYPKEI-SEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-N 438
            .::...|||.| :.||......:|||:......|.|||.|.|:||||.. |..:...:|:.|: :
  Rat   365 NEVQAGYPKRIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDET-RQLMDKGFPRLITDD 428

  Fly   439 WEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW-----WFGC 493
            :.|:...:||.| :..|:.|||:|...:.|           .|..|...|.     |..|
  Rat   429 FPGIEPQVDAVL-HAFGFFYFFRGSSQFEF-----------DPNARTVTHTLKSNSWLLC 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	14/30 (47%)
		Peptidase_M10	115..268	CDD:425668	79/156 (51%)
		HX	298..493	CDD:238046	60/202 (30%)
Mmp10	NP_598198.2	PG_binding_1	33..87	CDD:460223	14/30 (47%)
		Cysteine switch. /evidence=ECO:0000250	90..97		6/7 (86%)
		Peptidase_M10	108..264	CDD:425668	79/156 (51%)
		HX	286..476	CDD:238046	63/210 (30%)
		Hemopexin 1	286..335		15/56 (27%)
		Hemopexin 2	336..382		17/45 (38%)
		Hemopexin 3	384..432		16/48 (33%)
		Hemopexin 4	433..476		13/54 (24%)