DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42383 and UBXN11

DIOPT Version :9

Sequence 1:	NP_523847.2	Gene:	CG42383 / 37897	FlyBaseID:	FBgn0259729	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_001376485.1	Gene:	UBXN11 / 91544	HGNCID:	30600	Length:	520	Species:	Homo sapiens

Alignment Length:	430	Identity:	93/430 - (21%)
Similarity:	146/430 - (33%)	Gaps:	122/430 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EQKLSTFMKRHGVREEVARQYLSSNN-----------WSLEVASSTYESEAVSKKQE-------- 49
            |:|:|......|:...|:||..:|::           |.||........|.:||.|:
Human    47 EEKISVPSCYGGIGAPVSRQVPASHDSELMAFMTRKLWDLEQQVKAQTDEILSKDQKIAALEDLV 111

  Fly    50 ----PEKSSEHSQANE-----------SNRDLHSLLSEISRRKEGDHDGYQACASDSSTDH---D 96
                |..:....|..|           ..|::...||:...:..|:....:...|.:.::|   |
Human   112 QTLRPHPAEATLQRQEELETMCVQLQRQVREMERFLSDYGLQWVGEPMDQEDSESKTVSEHGERD 176

  Fly    97 TPAGKRVNINSSTPAITNNDSDRSLRVWGHGNRL---GSAHPINPPPRSATEDSDTEPADDEHTI 158
            ....|:......:.|....|.||.|......:.|   |... :.|.|..|...: .||
Human   177 WMTAKKFWKPGDSLAPPEVDFDRLLASLQDLSELVVEGDTQ-VTPVPGGARLRT-LEP------- 232

  Fly   159 VVLHLWSEGFSLDDGSLRLYALPENERFLRAILRGDFPEEMLRV-PR-VQLSVQDHTNESYRHLS 221
            :.|.|:..|..:.||..:.:..|..:|.||.||.|.||.|:.|: |. |...|.|..|:.|....
Human   233 IPLKLYRNGIMMFDGPFQPFYDPSTQRCLRDILDGFFPSELQRLYPNGVPFKVSDLRNQVYLEDG 297

  Fly   222 RKQFMGPGR----------------------------------------------PLNS------ 234
            ...|.|.||                                              |:..
Human   298 LDPFPGEGRVVGRQLMHKALDRVEEHPGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCC 362

  Fly   235 PSP---QILVVGPMPVEAQGLQLNERADT-----TTVQLRMADGSRVAGRFNL----THNVGDLY 287
            |.|   |.:||....:.|:..:..|..:|     :.::::..:|.:.   |.|    .:.:||:
Human   363 PLPARIQEIVVETPTLAAERERSQESPNTPAPPLSMLRIKSENGEQA---FLLMMQPDNTIGDV- 423

  Fly   288 QYARLARPEFSDRS-FVLMTAFPRQELVESDTRTLVQANL 326
             .|.||:....|.| |.:.:.|| ..|.:.||.||..|.|
Human   424 -RALLAQARVMDASAFEIFSTFP-PTLYQDDTLTLQAAGL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42383	NP_523847.2	UBA_TAP-C_like	10..39	CDD:270459	8/39 (21%)
		SEP	155..242	CDD:197786	30/143 (21%)
		p47_UBX	257..336	CDD:176365	21/80 (26%)
UBXN11	NP_001376485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		bchH	<119..>256	CDD:237377	27/145 (19%)
		SEP	235..306	CDD:400413	24/70 (34%)
		UBX_UBXN11	395..464	CDD:340597	20/73 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..520
		3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S	487..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900