DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42383 and SHP1

DIOPT Version :9

Sequence 1:	NP_523847.2	Gene:	CG42383 / 37897	FlyBaseID:	FBgn0259729	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_009495.1	Gene:	SHP1 / 852222	SGDID:	S000000154	Length:	423	Species:	Saccharomyces cerevisiae

Alignment Length:	428	Identity:	104/428 - (24%)
Similarity:	159/428 - (37%)	Gaps:	111/428 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EQKLSTFMKRHGVREEVARQYLSSNNWSLEVASSTYESEAVSKK-----------QEPEKSSEHS 57
            ::.:..||....|...:|.||||......|..:|.|.|:...:|           ||.....|..
Yeast     6 DETIQQFMALTNVSHNIAVQYLSEFGDLNEALNSYYASQTDDQKDRREEAHWNRQQEKALKQEAF 70

  Fly    58 QANESNRDLHSL--------------LSEISRRK---------------EGDHDGYQACASD--- 90
            ..|.||:.:::.              .:|..:||               .|::..:.: .||
Yeast    71 STNSSNKAINTEHVGGLCPKPGSSQGSNEYLKRKGSTSPEPTKGSSRSGSGNNSRFMS-FSDMVR 134

  Fly    91 ---SSTDHDTP-----AGKRVNINSSTPAITN-----------------------NDSDRSL--- 121
               ...|.|.|     .|:...:..:.|:..|                       :|.|..:
Yeast   135 GQADDDDEDQPRNTFAGGETSGLEVTDPSDPNSLLKDLLEKARRGGQMGAENGFRDDEDHEMGAN 199

  Fly   122 RVWGHGNRLGSAHPINPPPRSATEDSDTEPADD---------EHTIVVLHLWSEGFSLDDGSLRL 177
            |..|.|.||||           |.|:..|..:|         |.....:..|.|||.:.||.|..
Yeast   200 RFTGRGFRLGS-----------TIDAADEVVEDNTSQSQRRPEKVTREITFWKEGFQVADGPLYR 253

  Fly   178 YALPENERFLRAILRGDFPEEMLRV---PRVQLSVQDHTNESYRHLSRK--QFMGPGRPLNSPSP 237
            |..|.|..:|..:.:|..|.::|.|   ..|:::|....:|||:..:||  .|.|.|:.|.||.|
Yeast   254 YDDPANSFYLSELNQGRAPLKLLDVQFGQEVEVNVYKKLDESYKAPTRKLGGFSGQGQRLGSPIP 318

  Fly   238 QILVVGPMP------VEAQGLQLNE-RADTTTVQLRMADGSRVAGRFNLTHNVGDLYQYARLARP 295
            .......:|      .:.|.:..|| :...|::|:|.|:|.|.....|.|..|..||::......
Yeast   319 GESSPAEVPKNETPAAQEQPMPDNEPKQGDTSIQIRYANGKREVLHCNSTDTVKFLYEHVTSNAN 383

  Fly   296 EFSDRSFVLMTAFPRQELVESDTRTLVQANLCNVVVIQ 333
            ....|:|.|..|||.:. :.:|..||..|:|.|.||:|
Yeast   384 TDPSRNFTLNYAFPIKP-ISNDETTLKDADLLNSVVVQ 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42383	NP_523847.2	UBA_TAP-C_like	10..39	CDD:270459	10/28 (36%)
		SEP	155..242	CDD:197786	30/91 (33%)
		p47_UBX	257..336	CDD:176365	26/77 (34%)
SHP1	NP_009495.1	UBA_Ubx1_like	6..41	CDD:270536	10/34 (29%)
		SEP	231..323	CDD:197786	30/91 (33%)
		UBX_UBXN2	350..421	CDD:340468	25/72 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342006
Domainoid	1	1.000	44	1.000	Domainoid score	I3141
eggNOG	1	0.900	-	-		E1_KOG2086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I1291
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54012
OrthoFinder	1	1.000	-	-		FOG0001623
OrthoInspector	1	1.000	-	-		otm46484
orthoMCL	1	0.900	-	-		OOG6_102041
Panther	1	1.100	-	-	O	PTHR23333
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850