Protein Alignment CG42383 and Ubxn2a

DIOPT Version :10

• Sequence 1: NP_523847.2
• Gene: CG42383 / 37897
• FlyBaseID: FBgn0259729
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_663416.1
• Gene: Ubxn2a / 217379
• MGIID: 2442310
• Length: 258
• Species: Mus musculus
• Alignment Length: 208
• Identity: 64/208 - (30%)
• Similarity: 105/208 - (50%)
• Gaps: 24/208 - (11%)

  Fly   151 PADDEHTI-VVLHLWSEGFSLDDGSLRLYALPENERFLRAILRGDFPEEMLRV---PRVQLSVQD 211
            |.:.:..: |.:.||..||:::| ..|.|:...:::||.:|.:|:.|.|:..:   ..|.:.|:|
Mouse    55 PTEQKKQVDVNIKLWKNGFTVND-DFRSYSDGASQQFLNSIKKGELPSELWGIFDKEEVDVKVED 118

  Fly   212 HTNESYRHLSRK----QFMGPGRPLNSPSPQILVVGPMPVEA------QGLQLNERADTTTVQLR 266
            ..||..  :|.|    .|.|.|..|.|.:|:| |.....||.      ..:.||.....|.:|:.
Mouse   119 KKNEVC--MSTKPVFQPFSGQGHRLGSATPRI-VSKAKSVEVDNKSTLSAVSLNNLEPITRIQIW 180

  Fly   267 MADGSRVAGRFNLTHNVGDLYQYARLARPEFSDRS--FVLMTAFPRQELVESDTRTLVQANLCNV 329
            :|:|.|...|||::|.|..:..:  :.:.:.|.||  |.|.||.|....:: :|.||.:|:|.|.
Mouse   181 LANGERTVQRFNVSHRVSHIKDF--IEKYQGSQRSPPFALATALPFLRFLD-ETLTLEEADLKNA 242

  Fly   330 VVIQHLNEEQVEP 342
            |:||.| ::..||
Mouse   243 VIIQRL-QKTAEP 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42383	NP_523847.2	UBA_TAP-C_like	10..39	CDD:270459
		SEP	155..242	CDD:197786	28/94 (30%)
		UBX_UBXN2	262..334	CDD:340468	25/73 (34%)
Ubxn2a	NP_663416.1	Required for inhibition of CHRNA3 ubiquitination and translocation of CHRNA3 to the plasma membrane resulting in an increase in acetylcholine-gated nicotinic acetylcholine receptor currents. /evidence=ECO:0000269|PubMed:19474315	1..165		32/113 (28%)
		Required for interaction with CHRNA3. /evidence=ECO:0000250|UniProtKB:P68543	1..152		30/100 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		SEP	66..139	CDD:462348	22/75 (29%)
		Required for interaction with VCP. /evidence=ECO:0000250|UniProtKB:P68543	168..258		32/91 (35%)
		UBX_UBXN2A	168..251	CDD:340680	30/86 (35%)