Protein Alignment Slik and TAOK2

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_011544284.1
• Gene: TAOK2 / 9344
• HGNCID: 16835
• Length: 1242
• Species: Homo sapiens
• Alignment Length: 1345
• Identity: 280/1345 - (20%)
• Similarity: 475/1345 - (35%)
• Gaps: 514/1345 - (38%)

  Fly    32 DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQL---EDEENLSDHMVEIDILSEIKHPN 93
            ||.:.:..:.|:|.|:||.||.|:........|.|....   :..|...|.:.|:..|.:::|||
Human    23 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 87

  Fly    94 IVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRD 158
            .::....:..:...|:::|||.|.|.|.:.|. :|||.|.:||.|.....:||.:||.:.:||||
Human    88 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAVTHGALQGLAYLHSHNMIHRD 151

  Fly   159 LKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWS 223
            :||||:||:..|.|||.|||.::    .|...::|:|||||||||::|  ...:..||.|||:||
Human   152 VKAGNILLSEPGLVKLGDFGSAS----IMAPANSFVGTPYWMAPEVIL--AMDEGQYDGKVDVWS 210

  Fly   224 LGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDV 288
            ||||.||||:.:||...|:.|..|..|.::|.|.| |...||:.|.:|:...|.|.||.|||::|
Human   211 LGITCIELAERKPPLFNMNAMSALYHIAQNESPVL-QSGHWSEYFRNFVDSCLQKIPQDRPTSEV 274

  Fly   289 LMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDLDDDSASLQSQDIDKLPG 353
            |::|.|:.|......|.||:                :..:::..:||      :||.:.:.|:
Human   275 LLKHRFVLRERPPTVIMDLI----------------QRTKDAVRELD------NLQYRKMKKI-- 315

  Fly   354 TPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRPNHTKDDNAEAAAQQPPHTKVPA 418
                :.::|                              |:.|      .|||
Human   316 ----LFQEA------------------------------PNGP------GAEA------------ 328

  Fly   419 PAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPSP 483
                       |:.::.|||.:|
Human   329 -----------PEEEEQPTPCSQ------------------------------------------ 340

  Fly   484 LGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSVASS 548
                .|:|....:.|              .|::|                  :|..|...|:::|
Human   341 ----EAEPYMHRAGT--------------LTSLE------------------SSHSVPSMSISAS 369

  Fly   549 SSSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIID 613
            |.|.||                                     |||...|              |
Human   370 SQSSSV-------------------------------------NSLADAS--------------D 383

  Fly   614 NSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPA 678
            |                       |...:::....::..|    |..::.:|
Human   384 N-----------------------EEEEEEEEEEEEEEEG----PEAREMAM------------- 408

  Fly   679 PPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEG 743
                           :.|.|..:.|.|           |..|....||:|.|..:
Human   409 ---------------MQEGEHTVTSHS-----------SIIHRLPGSDNLYDDPY---------- 437

  Fly   744 VKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGS 808
                         ||.   |.|..:
Human   438 -------------QPE---ITPSPL---------------------------------------- 446

  Fly   809 DVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVV 873
                                   |.|||    |.|.|.|:
Human   447 -----------------------QPPAA----PAPTSTTS------------------------- 459

  Fly   874 KSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELR 938
                            :.|::...|.|. ....::..:..||.|...:::..:       :::|.
Human   460 ----------------SARRRAYCRNRD-HFATIRTASLVSRQIQEHEQDSAL-------REQLS 500

  Fly   939 ELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQE 1003
            ..|.:::|.:||...|..:.:..:|:...|.::|..:....:.|:.:.|||:|:.:.||..:..:
Human   501 GYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQ 565

  Fly  1004 NELRSSSKRIRSEQEQEL-----------KIFRENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSA 1057
            .|.|...:.|..:|::||           |:.:|.||:|:    ||....||.::.:...:::..
Human   566 AEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL----QENPSTPKREKAEWLLRQKEQ 626

  Fly  1058 MELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQL 1122
            ::....|:|...|...::..||..|:...|......:::::.|::..|..:|::    :||...|
Human   627 LQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQK----DLECALL 687

  Fly  1123 HERHQLSKR-HVKELCFMQRHQ---MIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPK--RI 1181
            ..:|:.::. .:::|..:||.:   ..::|:.||.......:|:|:::.:|...:.|..||  ::
Human   688 LRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKV 752

  Fly  1182 RAERKARDLMFRESLRISTNLDP-----EIERDRLKKFQEQEKKRYMQEERRFEVKHQKQL-EEL 1240
            ||.::...|    .|.|...|.|     .||:......||             .|..|:.| ||.
Human   753 RAGQRPPGL----PLPIPGALGPPNTGTPIEQQPCSPGQE-------------AVLDQRMLGEEE 800

  Fly  1241 RATRESAI--KELEQLQNEKRRALVE---------HEHSKLSEIDERLKG---ELREWR-EQLVP 1290
            .|..|..|  ||...|:.:::|.|.|         .:|..|  :||.:.|   |:.|.| ..|||
Human   801 EAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSL--VDEEVWGLPEEIEELRVPSLVP 863

  Fly  1291 RKQELNRQIKLAIDQHEKRFGLVTNR-------EEFEDQEVKLPA 1328
            :::.:       :.|.|.....:..:       ||||...|:.||
Human   864 QERSI-------VGQEEAGTWSLWGKEDESLLDEEFELGWVQGPA 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	111/280 (40%)
		PKK	958..1095	CDD:463600	32/147 (22%)
		PKK	1126..1266	CDD:463600	38/162 (23%)
TAOK2	XP_011544284.1	STKc_TAO2	12..319	CDD:270804	116/331 (35%)
		Smc	<474..>810	CDD:440809	79/367 (22%)