Protein Alignment Slik and MKK2

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_015185.1
• Gene: MKK2 / 855963
• SGDID: S000006061
• Length: 506
• Species: Saccharomyces cerevisiae
• Alignment Length: 306
• Identity: 92/306 - (30%)
• Similarity: 146/306 - (47%)
• Gaps: 42/306 - (13%)

  Fly    25 NNI----------KMDTDPAEFWEM---------VGELGDGAFGKVYKAQHKEQKRFAAAKMCQL 70
            |||          .:|....|.|..         :|.||:||.|.|.|.:.|..|:..|.|....
Yeast   183 NNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINT 247

  Fly    71 --EDEENLSDHMVEIDILSEIKHPNIVELYEAFSID--DKLWMLIEYCDGGALDSIMVELEK--- 128
              .|.|.......|:......|...||:.|..|:.:  ..:::.:||..|.:|::....|.|
Yeast   248 MNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGG 312

  Fly   129 PLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTF 193
            .::|..|..:.:.:..||::||..||||||:|..|:||..:|.:||.|||||.:..:::..  ||
Yeast   313 RISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAM--TF 375

  Fly   194 IGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELA------QMEPPNSEMSPMRVLLKIQK 252
            .||.::||||.:     :..||....|:||||:||:|:|      :.:.....::|:.:|..|..
Yeast   376 TGTSFYMAPERI-----QGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILT 435

  Fly   253 SEPPKLEQPS---RWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI 295
            ..|...::|.   .|||.|..|:...|.||.:.||:...:::|.:|
Yeast   436 FSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWI 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	88/290 (30%)
		PKK	958..1095	CDD:463600
		PKK	1126..1266	CDD:463600
MKK2	NP_015185.1	PKc_Pek1_like	212..499	CDD:270793	86/277 (31%)