Protein Alignment Slik and taok3a

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_009299531.1
• Gene: taok3a / 798408
• ZFINID: ZDB-GENE-100921-50
• Length: 903
• Species: Danio rerio
• Alignment Length: 1374
• Identity: 271/1374 - (19%)
• Similarity: 464/1374 - (33%)
• Gaps: 567/1374 - (41%)

  Fly    18 AKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQL---EDEENLSDH 79
            |.|...:.|:....||.|.:..:.|:|.|:||.||.|::.......|.|....   :..|...|.
Zfish    10 AVKDPEFANLFFKDDPEEVFCDLHEIGHGSFGAVYFARNSYSNEVVAIKKMSYNGKQTTEKWQDI 74

  Fly    80 MVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTE 144
            :.|:..|.:::|||.:|....:..|:..|:::|||.|.|.|.:.|. :|||.|.:||.:......
Zfish    75 IKEVKFLEQLRHPNTIEYKGCYLKDNTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALL 138

  Fly   145 GLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCET 209
            ||.:||.:.:||||:||||:|||..|.|||||||.::    .....::|:|||||||||::|  .
Zfish   139 GLAYLHSHNMIHRDVKAGNILLTEPGQVKLADFGSAS----IASPANSFVGTPYWMAPEVIL--A 197

  Fly   210 FRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKK 274
            ..:..|:.||||||||||.||||:.:||...|:.|..|..|.:::.|.| |.:.||..|..|:..
Zfish   198 MDEGQYEGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTL-QSNEWSDAFRSFVDY 261

  Fly   275 SLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSALQLDLDDD 339
            .|:|.||.||::..|::|.|:.|:   :|::.|:             |..:..:::..:||
Zfish   262 CLLKIPQDRPSSAELLRHEFVRRD---RPLRVLI-------------DLIQRTKDAVRELD---- 306

  Fly   340 SASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRPNHTKDDNA 404
              :||.:.:.|       ||...|.......|
Zfish   307 --NLQYRKMKK-------ILYQEKHNGPMGES--------------------------------- 329

  Fly   405 EAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKK 469
                                                       |::.||
Zfish   330 -------------------------------------------QEEEED---------------- 335

  Fly   470 HFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSP 534
                                                               |.:|        ..
Zfish   336 ---------------------------------------------------GDQA--------GC 341

  Fly   535 TASSIVSVQSVASSS-SSGSVSNAVLSSSTSLITINSDPPTPHHHQPLPPQPQHLILPNSLESVS 598
            ..:|:.|..|:.|:| |:||.|::|                                 |||:.|
Zfish   342 KMNSLGSNHSIPSTSVSTGSQSSSV---------------------------------NSLQEV- 372

  Fly   599 QITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQS 663
                                |.:....:.:|.:.:.   ||||.                 ||:
Zfish   373 --------------------PDDSCSELHHDYDSTL---ESSTQ-----------------HKK- 396

  Fly   664 SMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHL 728
                        ||            .|:.:|.        .|..||.           .|.||.
Zfish   397 ------------VP------------DAQHMDH--------QYIRDDI-----------PHRDHR 418

  Fly   729 MDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVR 793
            .|               ::.||:|..:.
Zfish   419 SD---------------LRPSSSERAQA------------------------------------- 431

  Fly   794 GRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEE 858
                                             ||.|                    |.|..
Zfish   432 ---------------------------------HNYK--------------------NRERF--- 440

  Fly   859 EEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDEN 923
                        |.:|||                                  :..:|.|:
Zfish   441 ------------ATIKSA----------------------------------SLVTRQIH----- 454

  Fly   924 GRIYDDHDFRKQELRE----LKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEA-- 982
                 :|: ::.||||    .|.:::|.:||...|   |.:.|.:.|    :.|..|:|..|.
Zfish   455 -----EHE-QENELREQMSGYKRMRRQHQKQLIAL---ENKLKAEMD----EHRLKLQKELETHA 506

  Fly   983 -----DMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEV--- 1039
                 :::.||::|....:|..:|...:.:...::|.::|::||..|.:..|::.:|.|:::
Zfish   507 NNAFIELEKLAKKHAIQTDKEMKTLSADEKKFQQQIVAQQKKELTTFLDTQKKQYKLCKEKIKEE 571

  Fly  1040 ----DLFPKDKRKDEFKQRRSAMELDHEEKE-------RAFLDS---------LKERHELLLRRL 1084
                ...||.::::...:.:..::....|:|       |||.|.         :.:|||....:|
Zfish   572 MSEDHSTPKKEKQERLSKHKENIQHSQAEEEAQLLGQQRAFYDRNCRAFKRKIMIKRHEFEQEQL 636

  Fly  1085 SEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHE 1149
            .|:            |.:|:.......|:|...:|    ...:|..|.:|.|..::...:.::|:
Zfish   637 REE------------LNKKKTQKEMEHAMLIRQDE----STQELEHRQLKTLQKLRMDLIRLQHQ 685

  Fly  1150 KELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKF 1214
            .||:.......|:|.::.:|..:|.|..||.::|........|:::.::.|.....:...:|:..
Zfish   686 TELENQIEYNNRRERELHRKHVLELRQQPKNLKAMELQIKKQFQDTCKVQTKQYKALRHHQLEVT 750

  Fly  1215 QEQEKKRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKG 1279
            .:.|.|..                 |:|.::...::|..|..:..:::.|...|:...:||..:.
Zfish   751 PKSEHKTV-----------------LKALKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEA 798

  Fly  1280 ELREWREQLVPRKQELNR-QIKLAID---QHEKRFGLVTNREEFEDQ--------EVKLPAHLRN 1332
            |.:..|:||....:.||. |.|:.|.   |||:      .:::.|.:        |.|:...|.:
Zfish   799 ECQALRQQLQQEMELLNAYQSKIKIQTEAQHER------EQQKLEQKVSLRRAHLEQKIEEELAS 857

  Fly  1333 IYNERSSRI 1341
            :..||:.||
Zfish   858 LQKERTDRI 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	110/281 (39%)
		PKK	958..1095	CDD:463600	33/166 (20%)
		PKK	1126..1266	CDD:463600	25/139 (18%)
taok3a	XP_009299531.1	Protein Kinases, catalytic domain	7..319	CDD:473864	121/345 (35%)