DRSC/TRiP Functional Genomics Resources

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Protein Alignment Slik and MAP2K5

DIOPT Version :10

Sequence 1:NP_726441.1 Gene:Slik / 37893 FlyBaseID:FBgn0035001 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_660143.1 Gene:MAP2K5 / 5607 HGNCID:6845 Length:448 Species:Homo sapiens


Alignment Length:332 Identity:100/332 - (30%)
Similarity:165/332 - (49%) Gaps:40/332 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 NLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQL 70
            :|||      ..|:.|::..|.:|:.....:.:.:|. |:|  |.||||.|....:..|.|:..|
Human   144 SLKK------SSAELKKILANGQMNEQDIRYRDTLGH-GNG--GTVYKAYHVPSGKILAVKVILL 199

  Fly    71 EDEENLSDH-MVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQ 134
            :....|... |.|::||.:.....|:..|.||.:::::.:..|:.|||:||     :.:.:.|..
Human   200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLD-----VYRKMPEHV 259

  Fly   135 IAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYW 199
            :..:...:.:|||:|...|::|||:|..|:|:...|.|||.|||||.:..:::.|  |::||..:
Human   260 LGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAY 322

  Fly   200 MAPELVLCETFRDNPYDHKVDIWSLGITLIELA-------QMEPPNSEMSPMRVLLKIQKSEPPK 257
            ||||.:..|     .|....|:|||||:.:|||       |::.....:.|:::|..|...:.|.
Human   323 MAPERISGE-----QYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPV 382

  Fly   258 LEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDD 322
            | ....:|:.|..|:.:.:.|.|:.||..:.||.|.||.:..|.          .|.||...|..
Human   383 L-PVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDG----------NAAVVSMWVCR 436

  Fly   323 ETEEPRN 329
            ..||.|:
Human   437 ALEERRS 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SlikNP_726441.1 STKc_SLK_like 31..310 CDD:132942 86/286 (30%)
PKK 958..1095 CDD:463600
PKK 1126..1266 CDD:463600
MAP2K5NP_660143.1 PB1_Map2k5 17..107 CDD:99717
Interaction with MAPK7. /evidence=ECO:0000250 18..25
Interaction with MAP3K2/MAP3K3. /evidence=ECO:0000250 64..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..144 100/332 (30%)
Interaction with MAPK7. /evidence=ECO:0000250 117..131
PKc_MKK5 164..442 CDD:132950 92/303 (30%)
Blue background indicates that the domain is not in the aligned region.

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