Protein Alignment Slik and Slk

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_006231620.1
• Gene: Slk / 54308
• RGDID: 3780
• Length: 1234
• Species: Rattus norvegicus
• Alignment Length: 1398
• Identity: 475/1398 - (33%)
• Similarity: 708/1398 - (50%)
• Gaps: 269/1398 - (19%)

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |||. |.:|:|.|  |..|||:.|.::|.|.:|.||||::|||||||||||||||:||....|||
  Rat     1 MSFF-NFRKIFKL--GSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAA 62

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:...:.||.|.|:|||||||:...|||||:|.:||..::.||:|||:|.|||:|::|:|||:||
  Rat    63 KVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 127

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            ||.||..|||...|.|.:||.||:|||||||||:|.|::|.:|||||||||||..|:|:.|:|||
  Rat   128 TESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|:|||.:|.|||:|.|:|||||||||:|::|||:.|::||||||||.|||||.|.|
  Rat   193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQ 257

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDA-KPIKDLLLEYKAEVVEEVVDDET 324
            |||||..|.|||||.|.|:...|.||..|:||.|:  .:|: ||:::|:.|.||||.|||.|.:.
  Rat   258 PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV--TVDSNKPVRELIAEAKAEVTEEVEDGKE 320

  Fly   325 EEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTK 389
            |:          |||                           :..|:|||  .|...|::..:..
  Rat   321 ED----------DDD---------------------------ETESALPI--PANKRASSDLSIA 346

  Fly   390 ATTPDRPNHTKDDNA---EAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKP 451
            ::..|:    ...||   |:.:::..|.       .|..:.....:.:.|||.....|..:....
  Rat   347 SSEEDK----LSQNACILESVSERTEHN-------TSGDKFSNKVLSEKPTPEGPEKAVDVDGPA 400

  Fly   452 EDV--AAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTT 514
            .||  ..|||.:::...    |.:.|:....|.    ..::|...|.||
  Rat   401 NDVNLETVAEPNDQAVG----FHENGREKKRPK----LESQPDTEDQQT---------------- 441

  Fly   515 AIEVAIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQ 579
                                     |.|..|...:.|..|   :|.::|..:....|....:..
  Rat   442 -------------------------VDVNLVGEGNDSNIV---ILETNTDCLKPEEDRNEENQE- 477

  Fly   580 PLPPQPQHLILPNSL---ESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESST 641
                     |:.|.|   |.:..|.:.|                  :.:||.:..:.
  Rat   478 ---------IIENKLTQSEEIKDIHIQT------------------MDLVSQETGEK-------- 507

  Fly   642 DDDFPSLDDSLG-------------DATTPPHKQSSMILAVNEPAGVVPAP--------PSQ--- 682
            :.||.::|:.:|             |.|     |..:|..::...|...||        .||
  Rat   508 EADFQAIDNEVGFTKEETQEKLGKDDKT-----QKVVISDISSEVGTDEAPGDTQKAAEQSQDAE 567

  Fly   683 -------PQTSSTVHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHV---SVV 737
                   |:.:.|:..:..:..|                 |.|:.....|...::...:   |.|
  Rat   568 GGAGEEAPEPAQTLTEKATEGPE-----------------AHGAEEEPRSGERVEDKQLEQQSAV 615

  Fly   738 TVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVR-----GRRG 797
            ..|:..|.....|......:|.     .::|:               .:||:.|:.     |..|
  Rat   616 CEGEGQVTSTSESTRATTEEPE-----TDEVD---------------QVSESNSIEELERLGVTG 660

  Fly   798 IEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSL---TNNHNHETIDEEE 859
            .|....||.|.....:... .:|:..|.....:.|.|||:....|||.|   .|.|:..|.::.|
  Rat   661 AEEQALGSKGEAATEVDLE-REENAQELPIKAEPQAPAASQPSEPPPVLIPSINIHSENTENKGE 724

  Fly   860 -------EVVIRPK----------ARVPAVVKSANAQ---------GLTKE--EIELRNLR--KK 894
                   |.::.|:          :...:.|:::::.         ..||:  .:.|:..|  ||
  Rat   725 MGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISSFLSKTKDSGSVSLQETRRQKK 789

  Fly   895 TRKRTRKFEIDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQ 959
            |.|:||||.:|||:::.|||:::  .|.:.:..:....|:||||||:||||:|:|.|.:|:.|.|
  Rat   790 TLKKTRKFIVDGVEVSVTTSKIV--TDSDSKTEELRFLRRQELRELRLLQKEEQKAQQQLNGKLQ 852

  Fly   960 QAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIF 1024
            |.:||..||||||..|.::.|:.:::.|.:|.||.:|:.||...|.||..:|||:.|||:||..|
  Rat   853 QQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKF 917

  Fly  1025 RENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHR 1089
            :..|:...:.:..||:..||:.||:..|:|:..:......:|:.|:...::..:..|:::.::.:
  Rat   918 QNMLRNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGALKKIIQQQK 982

  Fly  1090 DHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQ 1154
            ..||.|.|..|..||..:|.|||.:|||||:.|.|:|||.|:.:|:..|:||||::.|||||.:|
  Rat   983 AELANIERECLNNKQQLLRAREAAIWELEERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQ 1047

  Fly  1155 VKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEK 1219
            ::|..||..|::..:||.|:..|||..|:|.|.|..||::||||::...|:.:|:::|:|..||:
  Rat  1048 MQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEE 1112

  Fly  1220 KRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREW 1284
            ||...|......||:.|:.:|:...|:.::||.||||||...|||||..||.|:||....||:||
  Rat  1113 KRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEW 1177

  Fly  1285 REQLVPRKQELNRQIKLAIDQHEKRFGLVTNRE 1317
            ||:|.|||:.|..:....:.:.|..|.:....|
  Rat  1178 REKLRPRKKTLEEEFARKLQEQEVFFKMTGESE 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	174/279 (62%)
		PKK	958..1095	CDD:463600	45/136 (33%)
		PKK	1126..1266	CDD:463600	61/139 (44%)
Slk	XP_006231620.1	STKc_SLK	28..309	CDD:270811	175/282 (62%)
		PKK	851..989	CDD:463600	45/137 (33%)
		PKK	1019..1159	CDD:463600	61/139 (44%)