Protein Alignment Slik and Stk10

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_033314.2
• Gene: Stk10 / 20868
• MGIID: 1099439
• Length: 966
• Species: Mus musculus
• Alignment Length: 1347
• Identity: 430/1347 - (31%)
• Similarity: 625/1347 - (46%)
• Gaps: 402/1347 - (29%)

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |:| .|.:::..|...|.:|.|.|.:::.|.||.:.||:|||||||||||||||::||....|||
Mouse     1 MAF-ANFRRILRLSTFEKRKSREYEHVRRDLDPNDVWEIVGELGDGAFGKVYKAKNKETGALAAA 64

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:.:.:.||.|.|::|||:||:...||.||:|..|:..|.|||::||:|.|||:|:||:||::.|
Mouse    65 KVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGL 129

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            |||||..||:.|.|.|.|||..::|||||||||||:|:||.::||||||||||..|:||.|:|||
Mouse   130 TEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIG 194

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|||||.:|.|||:|.|||||||||||:||:|||:.|::||||||||.||:||.|..
Mouse   195 TPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT 259

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETE 325
            ||:||.||.||||.:|.|:|:.||:...|:||.|::|....|.:::|:.|.||||:||:.|...:
Mouse   260 PSKWSVEFRDFLKIALDKNPETRPSAAQLLQHPFVSRVTSNKALRELVAEAKAEVMEEIEDGRED 324

  Fly   326 EPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKA 390
            .....|                :|.:|                    |:.
Mouse   325 GEEEDA----------------VDAVP--------------------PLV--------------- 338

  Fly   391 TTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKK----P 451
                  |||:|.           ..|..|:..|::.........||:.|.:|.:....:.    |
Mouse   339 ------NHTQDS-----------ANVTQPSLDSNKLLQDSSTPLPPSQPQEPVSGSCSQPSGDGP 386

  Fly   452 EDVAAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTSPKKLATPEPTSPVTTAI 516
            ....:.|:...|.::|.|            .|:.|..::|.:.|::
Mouse   387 LQTTSPADGLSKNDNDLK------------VPVPLRKSRPLSMDAR------------------- 420

  Fly   517 EVAIGQEAMEP-KPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQP 580
             :.:.:|...| :.:.|||.||.        |..::.|..|:
Mouse   421 -IQMDEEKQIPDQDENPSPAASK--------SQKANQSRPNS----------------------- 453

  Fly   581 LPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHLHESSTDDDF 645
                       ::||::.
Mouse   454 -----------SALETLG----------------------------------------------- 460

  Fly   646 PSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKLDESEVLIVSPSYADDD 710
                   |:|.|               .|.:..|.|                    |:||
Mouse   461 -------GEALT---------------NGGLELPSS--------------------VTPS----- 478

  Fly   711 SAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQPNGVGIVPEDVNIIVNRF 775
                         ||....|.|::|.....|.|..:
Mouse   479 -------------HSKRASDCSNLSTSESMDYGTSL----------------------------- 501

  Fly   776 KQEKRSPDSSLS-ENGSVRGRRGIEVLVGGSGGSDVDSIGTNTSQESRHETDHNNKQQYPAAALM 839
                 |.|.||: |.||:
Mouse   502 -----SADLSLNKETGSL----------------------------------------------- 514

  Fly   840 PPPPPSLTNNHNHETIDEEEEVVIRPKARVPAVVKSANAQGLTKEEIELRNLRKKTRKRTRKFEI 904
                 ||..:                                        .|..||.||||:|.:
Mouse   515 -----SLKGS----------------------------------------KLHNKTLKRTRRFVV 534

  Fly   905 DGVQMTTTTSRVIYGD---DENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQD 966
            |||:::.|||::|..|   ||..|.     .|:||||||:||||:|.:.||:|..|.:...||..
Mouse   535 DGVEVSITTSKIISEDEKKDEEMRF-----LRRQELRELRLLQKEEHRNQTQLSSKHELQLEQMH 594

  Fly   967 RRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQE 1031
            :|||||.::.:|.|:.:::.|.||.||.|||.||......:..:||||.||:::...|:|.|||.
Mouse   595 KRFEQEINAKKKFYDVELENLERQQKQQVEKMEQDHSVRRKEEAKRIRLEQDRDYAKFQEQLKQM 659

  Fly  1032 IRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEK----ERAFLDSLKERHELLLRRLSEKHRDHL 1092
            .:.:|.||:..|:.:||:..||:   || :|.:|    :|.|:...||..||.:|:|:.::|..:
Mouse   660 KKEVKSEVEKLPRQQRKESMKQK---ME-EHSQKKQRLDRDFVAKQKEDLELAMRKLTTENRREI 720

  Fly  1093 ATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKR 1157
            ....|:.|.:||..:|.|||.|||:||.||.|||||.|:.:|:..|:|||.::.:||||.:|::|
Mouse   721 CDKERDCLSKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHDLLRKHEKEREQMQR 785

  Fly  1158 MLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRY 1222
            ..||..|.:..:|..||..|||..|::.|.|..|:::||.|:.......:|:::|:|.:||:||.
Mouse   786 YNQRMMEQLKVRQQQEKARLPKIQRSDGKTRMAMYKKSLHINGAGSASEQREKIKQFSQQEEKRQ 850

  Fly  1223 MQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQ 1287
            ..|..:.:.||:.|:.::.|..||.:.||:||||||...|||||..||..:||.....|:|||::
Mouse   851 KAERLQQQQKHENQMRDMVAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQSLKEWRDK 915

  Fly  1288 LVPRKQELNRQIKLAIDQHEKRFGLVTNREEFEDQEVKLPAHLRNIY 1334
            |.|||:.|...:.....:.|..|.|   .||.|.:.. .|:...|.:
Mouse   916 LRPRKKALEEDLNQKKREQEMFFKL---SEEAEPRPT-TPSKASNFF 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	170/278 (61%)
		PKK	958..1095	CDD:463600	51/140 (36%)
		PKK	1126..1266	CDD:463600	56/139 (40%)
Stk10	NP_033314.2	STKc_STK10	23..314	CDD:132975	175/290 (60%)
		Activation segment. /evidence=ECO:0000250	175..224		37/48 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..497		44/347 (13%)
		PKK	586..724	CDD:463600	51/141 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..692		12/35 (34%)
		PKK	754..894	CDD:463600	56/139 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	826..865		11/38 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..966		19/62 (31%)