DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Slik and BUB1B-PAK6

DIOPT Version :10

Sequence 1:NP_726441.1 Gene:Slik / 37893 FlyBaseID:FBgn0035001 Length:1703 Species:Drosophila melanogaster
Sequence 2:NP_001122100.1 Gene:BUB1B-PAK6 / 106821730 HGNCID:52276 Length:681 Species:Homo sapiens


Alignment Length:264 Identity:101/264 - (38%)
Similarity:161/264 - (60%) Gaps:7/264 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVE 96
            ||....:...::|:|:.|.|..|:.|...|..|.||..|..::.......|:.|:.:.:|.|:||
Human   402 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVE 466

  Fly    97 LYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKA 161
            :|:::.:.::||:|:|:..||||..|:.::.  |.|.|||.||:.:.:.|.:||...|||||:|:
Human   467 MYKSYLVGEELWVLMEFLQGGALTDIVSQVR--LNEEQIATVCEAVLQALAYLHAQGVIHRDIKS 529

  Fly   162 GNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGI 226
            .::|||::|.|||:|||..|:....:.|..:.:|||||||||::     ..:.|..:||||||||
Human   530 DSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-----SRSLYATEVDIWSLGI 589

  Fly   227 TLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQ 291
            .:||:...|||....||::.:.:::.|.||||:...:.|....|||::.||:|||.|.|...|:.
Human   590 MVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLD 654

  Fly   292 HAFI 295
            |.|:
Human   655 HPFL 658

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SlikNP_726441.1 STKc_SLK_like 31..310 CDD:132942 101/264 (38%)
PKK 958..1095 CDD:463600
PKK 1126..1266 CDD:463600
BUB1B-PAK6NP_001122100.1 PBD 11..67 CDD:395634
STKc_PAK6 385..681 CDD:270821 101/264 (38%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.