Protein Alignment Slik and si:dkey-81j8.6

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_021327922.2
• Gene: si:dkey-81j8.6 / 101885880
• ZFINID: ZDB-GENE-091116-12
• Length: 1293
• Species: Danio rerio
• Alignment Length: 1413
• Identity: 423/1413 - (29%)
• Similarity: 660/1413 - (46%)
• Gaps: 263/1413 - (18%)

  Fly     7 LKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLE 71
            |.:.|.| |.|.|:.|.|.|:|.|.||.:.||.:|||||||||||||||::......|.|:.::.
Zfish     5 LMRFFRL-GVEKKRVRHYENLKRDVDPHQSWETLGELGDGAFGKVYKAQNQTTGVLGAVKVIEVR 68

  Fly    72 DEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIA 136
            .||.|.|::.|||||:..:||||:.|.:|...:..||:|:|||.|||||.||:|||:.|||.||:
Zfish    69 SEEQLDDYITEIDILAACRHPNILSLLDAIFFEGWLWILLEYCPGGALDDIMLELERGLTEQQIS 133

  Fly   137 YVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMA 201
            .||....:.|.:||::.:|||||||||:||||:|.||||||||||||.:|:||..||||||||||
Zfish   134 EVCWQTLQALFYLHQHHIIHRDLKAGNILLTMDGQVKLADFGVSAKNDYTLQKRSTFIGTPYWMA 198

  Fly   202 PELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSK 266
            ||:::|||.:||||..|.||||:||||||.|:||||:..::||||||||.||.||.|..|.:||.
Zfish   199 PEVIMCETSKDNPYTSKADIWSMGITLIEAAEMEPPHHSLNPMRVLLKITKSPPPTLSNPRQWSS 263

  Fly   267 EFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETEEPRNSA 331
            .|.|||::||.|:|:.|..|..||.|.|.....|.:.:|:|:.|.||||. |||::|:.....|:
Zfish   264 HFQDFLRRSLQKNPEARWGTQQLMAHPFSYAGRDGRALKELIAEAKAEVT-EVVENESLFNIQSS 327

  Fly   332 LQLDLDDDSASL---QSQDIDKL----PGTP--TSILRDAKEQSQPSSSL-PIAAAATAAAAATT 386
            ::..:..:|...   ..|.|::.    |.||  ||:| |...||..:|.| |.......|:.||.
Zfish   328 VKDTITTESEKTLPRPEQAIEEQGPQEPETPKKTSVL-DTVPQSPINSELNPEVKVTRRASQATN 391

  Fly   387 TTKATTPDR----PNH-------------------------TKDDNAEAAAQQPPHTKVPAPAPP 422
            ..|.....|    |.:                         ||:....:||:.       ....|
Zfish   392 QVKTQKRARRLSVPGNLLSFLSGGSRRCKSGFWGDNSPVQLTKNSEDSSAAES-------VGTCP 449

  Fly   423 S----SQQTPPPQVQQPPTPPAQPTAAVLQKKPEDVAAVAETSEKTESDKKHFVKKGKAPPPPS- 482
            |    |:.|..|:.:.|.         |:......||.:.:..:..|:||...:....|....|
Zfish   450 SDGTESENTAKPKEETPD---------VVDAPSNKVADIKDEVDTEETDKNSNLSSAPAHTTVSS 505

  Fly   483 ---PLGLANAKPAASD-----------SQTSPKKLATP----------EPTSPVTTAIEVAIGQE 523
               .|||......|::           .||..|.|..|          ..|..|...:|..:..:
Zfish   506 ESDTLGLTKEDTEAAEKRNGTVTNSDNDQTFWKSLQIPAVLDKDATHQHSTQVVALCLETTLALK 570

  Fly   524 AMEPKPQP------PSPTASSIVSVQSVASSSSSGSV-------------SNAVLSSSTSLITIN 569
            ....:..|      ..|..:|..::.:..:.....|:             |...|.:..::..:.
Zfish   571 TNRNEQNPNDYLNLACPLKTSTFTLDNTKTPEVPSSIFPERAPDFKNEQPSTEPLETEETVEELE 635

  Fly   570 SDPPTPHHHQPLPPQPQ------HLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSN 628
            :|..|....:.|..:.|      |:.:....|..:::......|.....:|.....:.     |:
Zfish   636 TDGGTEEESRLLETEDQTIIKEDHIAMKVESEDFTEVISEVVRHEDFNSNNEKSEEEE-----SS 695

  Fly   629 DMNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARK 693
            :.:|.|...|.||..:..::.|...|           :.::||.:.:               :||
Zfish   696 EKDKETTEEECSTSKEENTMKDDHED-----------VDSINENSEI---------------SRK 734

  Fly   694 LDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSNELVKRQP 758
            .||.   :.:|...:..:..::.:...|:...|:|                 .|::|||.|.:..
Zfish   735 SDEE---METPIQNETTNITDSQTPEMSNKEEDNL-----------------EKETSNEGVAQDA 779

  Fly   759 NGVGIVPEDVNIIVNRFKQEKRSPDSSL---------SENG-------SVRGRRGIEVLVGGSGG 807
            .......|:...|.|  |..|.:.:.|:         ||:.       .|:..:..|.|..|.
Zfish   780 TDSKEPEEEFPEISN--KTHKTTEEDSMDAVEDTTVVSESKLKKQVMFVVQDDKNKEKLANGL-- 840

  Fly   808 SDVDSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETIDEEEEVVIRPKARVPAV 872
            :|.||:..:.|..|.|: :.|.....|.:...||..|..             |..:.|.
Zfish   841 NDSDSVLPHESNGSTHK-ESNEDMIPPLSPTSPPMSPGF-------------EGEMHPS------ 885

  Fly   873 VKSANAQGLTKEEIELRNLRKKTRKRTRKFEIDGVQMTTTTSRVIYGDDENGRI--YDDHDFRKQ 935
                                :.|.|:||||.:||.:::.|||:|:...|...::  |:    |:|
Zfish   886 --------------------RMTVKKTRKFMVDGREVSVTTSKVVSEGDSKEKLMRYN----RRQ 926

  Fly   936 ELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTYEADMDMLARQHKQLVEKTEQ 1000
            ||..|||||::|:::..:|.||.||.:||..|..|||.:|.::.|:::::.|.:|::|...:.|.
Zfish   927 ELHALKLLQREEQREHAQLELKLQQQREQMFRHIEQEMTSKKQYYDSELERLEKQYQQQSGQMEA 991

  Fly  1001 TQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKDKRKDEFKQRRSAMELDHEEK 1065
            ...::||..::||:::||:||                              .::.||::.|.:|:
Zfish   992 EHTSKLREDARRIKAQQEKEL------------------------------SRKSSALKADPKEE 1026

  Fly  1066 ERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTREALLWELEEKQLHERHQLSK 1130
            :|......:|.:|.|.:.:.| |:..:|::......:.|...|.|||::||||::.|.|::.|.|
Zfish  1027 QRFLQKQQQELNEALQKGVQE-HKRKVASMEWEITVKSQQLKRAREAVIWELEQRHLQEKYHLFK 1090

  Fly  1131 RHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKRALPKRIRAERKARDLMFRES 1195
            :.|||...:||.|:..||.|:.::..|..|...|:....|..|:.:..|..:||.|:|....:..
Zfish  1091 QQVKEQYSLQRQQLTKRHNKDKERASRFQQSLLEEQKSLQAQERASFLKTQKAEAKSRLNQLKME 1155

  Fly  1196 LRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEELRATRESAIKELEQLQNEKRR 1260
            ||......|| :|..|.:...:|:.|..||::..:..|:.||:.::...:::..||:||||||.:
Zfish  1156 LRKQGLSGPE-QRQHLTQLLSEEEARQKQEKQSLQESHESQLKAVQEQCDASTAELQQLQNEKLQ 1219

  Fly  1261 ALVEHEHSKLSEIDERLKGELREWREQLVPRKQELNRQIKLAIDQHEK 1308
            .||:.|..|:..:::....||.|||::|..||:.|...  ||..:.||
Zfish  1220 VLVDMEKKKIKALEDEHTLELNEWRDKLACRKEVLEED--LARRRREK 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	159/278 (57%)
		PKK	958..1095	CDD:463600	33/136 (24%)
		PKK	1126..1266	CDD:463600	44/139 (32%)
si:dkey-81j8.6	XP_021327922.2	None