Protein Alignment mAChR-A and TyrR

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Alignment Length: 790
• Identity: 175/790 - (22%)
• Similarity: 272/790 - (34%)
• Gaps: 281/790 - (35%)

  Fly    59 LTALFENLTSTAASGLYDPYSGMYGNQTNGT--IGFETKGPRYSLASM----------------- 104
            ::.::|:..:....|......|.|.:..|||  :.....||...:.:.
  Fly    45 ISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYD 109

  Fly   105 -------VVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFA 162
                   :::..|.|....|||.||.:|:::....::|:||:|.|:.|||:||..:|...||...
  Fly   110 LVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAV 174

  Fly   163 VTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNR-AAVMIG 226
            ...::|.|.||.::||.|::||.|...||:|:|..||.|||.:|||||||..||.:.| |.:||.
  Fly   175 AVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMIL 239

  Fly   227 AAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRI 291
            ..|.::|.:..|.:..| |..|:|.:  .||  ::.:...|:.| :|:.:|:.|:.:|.::|.||
  Fly   240 IVWLLALAITCPPMLGW-YEPGRRDL--REC--RYNQNEGYVIF-SAMGSFFIPMAVMIYVYARI 298

  Fly   292 WRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPD 356
                                                        :.|..:.||.
  Fly   299 --------------------------------------------SCVIASRHDN----------- 308

  Fly   357 AESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEE 421
                 ||::       .:|::|.         |.||.                .|.::...|||:
  Fly   309 -----MTDI-------SVHNKKF---------KRYTA----------------ADVENELSEQEQ 336

  Fly   422 PSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASI 486
            .|.:|...        :.:.||..|...:                                   .
  Fly   337 HSSVGQRQ--------RQATSRTFSNQTI-----------------------------------A 358

  Fly   487 SQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDS 551
            .:||:|                   .:::::|.:..|.|...|.|.|..|..|      .||..|
  Fly   359 KELQDM-------------------MLSDSDNCAAMGAGGAGGGGGGASSATG------GTHCQS 398

  Fly   552 RTLPVINRINSRSVSQDSVYTILIRLPSDGASSN---AANG------------------------ 589
                                  |:.|||.|...:   |.||
  Fly   399 ----------------------LLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMT 441

  Fly   590 GGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGR 654
            .|.|||     |:.|..|....|       .|.|.......|:.        |.|...|
  Fly   442 SGMGPG-----SSLLDAQWQSQP-------PGQTGQVQTHSLSQ--------PPRTHSF------ 480

  Fly   655 RMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTL 719
            |.||.:.|...|.:...........|.......|...|..|:::.:   .:....::|:|..:||
  Fly   481 RHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLS---NRITSLKKENKTTQTL 542

  Fly   720 SAILLSFIITWTPYNILVLIKPLTT---CSDCIPTEL-WDFFYALCYINSTINPMCYALCNATFR 780
            |.::..||..|.|:.|..||.|...   .|..:...| |     |.:.||.|||..||..:..||
  Fly   543 SIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTW-----LGWFNSAINPFIYAFYSVDFR 602

  Fly   781 RTYVRILTCK 790
            ..:.| ||||
  Fly   603 AAFWR-LTCK 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	71/195 (36%)
		TM helix 1	106..132	CDD:320428	8/25 (32%)
		TM helix 2	139..165	CDD:320428	10/25 (40%)
		TM helix 3	177..207	CDD:320428	15/29 (52%)
		TM helix 4	219..242	CDD:320428	7/23 (30%)
		TM helix 5	265..294	CDD:320428	9/28 (32%)
		7tm_GPCRs	<707..783	CDD:475119	26/79 (33%)
		TM helix 6	716..738	CDD:410628	8/21 (38%)
		TM helix 7	751..776	CDD:410628	10/25 (40%)
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	72/235 (31%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	15/29 (52%)
		TM helix 4	232..255	CDD:320189	7/22 (32%)
		TM helix 5	272..297	CDD:320189	7/25 (28%)
		7tm_GPCRs	<533..605	CDD:475119	26/76 (34%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	10/29 (34%)