DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-A and TyrR

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001287381.1	Gene:	TyrR / 42136	FlyBaseID:	FBgn0038542	Length:	631	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	175/790 - (22%)
Similarity:	272/790 - (34%)	Gaps:	281/790 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LTALFENLTSTAASGLYDPYSGMYGNQTNGT--IGFETKGPRYSLASM----------------- 104
            ::.::|:..:....|......|.|.:..|||  :.....||...:.:.
  Fly    45 ISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYD 109

  Fly   105 -------VVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFA 162
                   :::..|.|....|||.||.:|:::....::|:||:|.|:.|||:||..:|...||...
  Fly   110 LVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAV 174

  Fly   163 VTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNR-AAVMIG 226
            ...::|.|.||.::||.|::||.|...||:|:|..||.|||.:|||||||..||.:.| |.:||.
  Fly   175 AVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMIL 239

  Fly   227 AAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRI 291
            ..|.::|.:..|.:..| |..|:|.:  .||  ::.:...|:.| :|:.:|:.|:.:|.::|.||
  Fly   240 IVWLLALAITCPPMLGW-YEPGRRDL--REC--RYNQNEGYVIF-SAMGSFFIPMAVMIYVYARI 298

  Fly   292 WRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPD 356
                                                        :.|..:.||.
  Fly   299 --------------------------------------------SCVIASRHDN----------- 308

  Fly   357 AESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEE 421
                 ||::       .:|::|.         |.||.                .|.::...|||:
  Fly   309 -----MTDI-------SVHNKKF---------KRYTA----------------ADVENELSEQEQ 336

  Fly   422 PSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASI 486
            .|.:|...        :.:.||..|...:                                   .
  Fly   337 HSSVGQRQ--------RQATSRTFSNQTI-----------------------------------A 358

  Fly   487 SQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDS 551
            .:||:|                   .:::::|.:..|.|...|.|.|..|..|      .||..|
  Fly   359 KELQDM-------------------MLSDSDNCAAMGAGGAGGGGGGASSATG------GTHCQS 398

  Fly   552 RTLPVINRINSRSVSQDSVYTILIRLPSDGASSN---AANG------------------------ 589
                                  |:.|||.|...:   |.||
  Fly   399 ----------------------LLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMT 441

  Fly   590 GGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGR 654
            .|.|||     |:.|..|....|       .|.|.......|:.        |.|...|
  Fly   442 SGMGPG-----SSLLDAQWQSQP-------PGQTGQVQTHSLSQ--------PPRTHSF------ 480

  Fly   655 RMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTL 719
            |.||.:.|...|.:...........|.......|...|..|:::.:   .:....::|:|..:||
  Fly   481 RHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLS---NRITSLKKENKTTQTL 542

  Fly   720 SAILLSFIITWTPYNILVLIKPLTT---CSDCIPTEL-WDFFYALCYINSTINPMCYALCNATFR 780
            |.::..||..|.|:.|..||.|...   .|..:...| |     |.:.||.|||..||..:..||
  Fly   543 SIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTW-----LGWFNSAINPFIYAFYSVDFR 602

  Fly   781 RTYVRILTCK 790
            ..:.| ||||
  Fly   603 AAFWR-LTCK 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	54/124 (44%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	66/193 (34%)
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	53/121 (44%)
TyrR	NP_001287381.1	7tm_1	133..>298	CDD:278431	64/170 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840