Protein Alignment mAChR-A and Dop2R

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 790
• Identity: 175/790 - (22%)
• Similarity: 290/790 - (36%)
• Gaps: 241/790 - (30%)

  Fly    36 TTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYS 100
            :|.:.|:|.:|.....|..|:.||  |.:|||     |||  ..|...|.||.|:..........
  Fly   316 STVSGTSTIAPGVAITGSRGSGLL--LEQNLT-----GLY--LDGYRLNCTNETLNLTDSCGELR 371

  Fly   101 LASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTT 165
            :........:..:...:|:.||::|::|...::.|||::|||:.||||||..:..:.||......
  Fly   372 VVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFL 436

  Fly   166 ILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWG 230
            :.|.|.|..:|||.::|:|.:.|.:|:.||:.||.|||.:||:|:.|...:.:.|..:.|...|.
  Fly   437 VNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWA 501

  Fly   231 ISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRET 295
            ||..:      ..|.:.|....|..|..:.......:|.: ::|::||.|..||.||||.|::..
  Fly   502 ISAAI------GSPIVLGLNNTPNREPDVCAFYNADFILY-SSLSSFYIPCIIMVFLYWNIFKAL 559

  Fly   296 KKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESV 360
            :.|        |.|:.::::.:.|:       .:||                   |.....|::.
  Fly   560 RSR--------ARKQRAARKPHLSE-------LTGG-------------------SVIENIAQTR 590

  Fly   361 YMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDL 425
            .:....:||..|........ .:|||.                   ||..:.:|
  Fly   591 RLAETALDSSRHASRILPDE-AATNTA-------------------SGSNEEED----------- 624

  Fly   426 GYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQ 490
                    |..:...:..|                      .::::|.|...:    ||::.:..
  Fly   625 --------ENAISPDIDDC----------------------HVIVNDKSTEFM----LATVVEET 655

  Fly   491 EMSAVTASTTAN--VNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRT 553
            ..|.|...||..  |....|||
  Fly   656 GNSVVAQITTQPQLVVADPNGN------------------------------------------- 677

  Fly   554 LPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIH 618
                         .||.|          |:||..:...|...|.|:|:.|.:.:...:|
  Fly   678 -------------HDSGY----------AASNVDDVLAGVAPASASAATSAAPRSSGSP------ 713

  Fly   619 EDGPTTTAAAAPLASAAATRRPL----PSR-----------DSEFSL-PLG-------RRMSHAQ 660
            .|.|..:.|....:|.::.|||.    |.|           :|..:: ||.       ..|:.|:
  Fly   714 PDSPLPSGATLQRSSVSSQRRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLAR 778

  Fly   661 HDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLS 725
            :|:.|........:..|....|:      ...:.....|:|||::....::|.||.|||:.:|..
  Fly   779 NDSTLSTTSKTSSRKDKKNSQAS------RFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGV 837

  Fly   726 FIITWTPY---NILVLIKPLTTCS----DCIP------TELWDFFYALCYINSTINPMCYALCNA 777
            |:..|.|:   ||:..:     |:    ||.|      ...|     |.||||.:||:.|.:.|.
  Fly   838 FLFCWLPFFSCNIMDAM-----CAKFKKDCRPGLTAYMMTTW-----LGYINSFVNPVIYTIFNP 892

  Fly   778 TFRRTYVRIL 787
            .||:.:.:|:
  Fly   893 EFRKAFKKIM 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	62/194 (32%)
		TM helix 1	106..132	CDD:320428	5/25 (20%)
		TM helix 2	139..165	CDD:320428	11/25 (44%)
		TM helix 3	177..207	CDD:320428	13/29 (45%)
		TM helix 4	219..242	CDD:320428	5/22 (23%)
		TM helix 5	265..294	CDD:320428	12/28 (43%)
		7tm_GPCRs	<707..783	CDD:475119	28/88 (32%)
		TM helix 6	716..738	CDD:410628	9/24 (38%)
		TM helix 7	751..776	CDD:410628	9/24 (38%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	63/203 (31%)
		TM helix 1	377..403	CDD:320181	5/25 (20%)
		TM helix 2	410..436	CDD:320181	11/25 (44%)
		TM helix 3	448..478	CDD:320181	13/29 (45%)
		TM helix 4	490..513	CDD:320181	6/28 (21%)
		TM helix 5	529..558	CDD:320181	12/29 (41%)
		7tm_GPCRs	<822..898	CDD:475119	28/85 (33%)
		TM helix 6	828..850	CDD:320181	7/21 (33%)
		TM helix 7	866..891	CDD:320181	9/29 (31%)