Protein Alignment: mAChR-A and chrm5

• Sequence 1: NP_523844.2
• Gene: mAChR-A
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_017952476.1
• Gene: chrm5
• XenbaseID: XB-GENE-986590
• Length: 525
• Species: Xenopus tropicalis
• Alignment Length: 730
• Identity: 230/731 (31%)
• Similarity: 314/731 (43%)
• Gaps: 246/731 (34%)

  Fly    84 NQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAI 148
            |.:|||:..:.    :||..::.:..|:||:|.:|:.||::||:|||::.||:|::||:|.|||.
 Frog     9 NNSNGTVPLKA----HSLWEVITIATVSAIVSLITIVGNILVMVSFKVNSQLKTVNNYYLLSLAC 69

  Fly   149 ADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYR 213
            ||..||..||.|:....::|:|.||.:.||.||||||:||||||:|||:||||||||:|||||||
 Frog    70 ADLIIGIFSMNLYTSYILIGHWSLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 134

  Fly   214 AKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFY 278
            ||||..||.:|||.||.||.:||.|.|..|.|..|.||||.:||.|||: ....||||||:||||
 Frog   135 AKRTPKRAGLMIGLAWFISFILWAPAILCWQYFVGGRTVPPEECQIQFL-YEPIITFGTAIAAFY 198

  Fly   279 FPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDH 343
            .||::|..||.||::||:||.|||..||.
 Frog   199 LPVSVMTILYCRIYKETEKRTKDLAELQG------------------------------------ 227

  Fly   344 DTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFG------SIKEWCI 402
                   |||..|.|                     .::...|:.||  ||.      :.:|.|.
 Frog   228 -------SESVADFE---------------------MMRPQGTLFKS--CFSCKQQTRTKRERCQ 262

  Fly   403 AWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPS 467
            |.|                                 ||.||.|:..|
 Frog   263 ASW---------------------------------SSSSRSTTTTV------------------ 276

  Fly   468 ILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNT-SGNGNGAINNNNNASHNGNGAVNGNG 531
                .::.:|..........||...|:..:|...:..| .....||..|...|
 Frog   277 ----KITHSPNTCNEWIKEDQLTTCSSYPSSDDEDKQTKEAVFQGAYENQTEA------------ 325

  Fly   532 AGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGA 596
                            .::..|..::.:......:.:|....|.                  ||.
 Frog   326 ----------------QKEEETKQILTKEQPGLSNYESERFFLT------------------PGK 356

  Fly   597 GAAASASLSMQGDCAPSIK---MIHEDGPTTT------AAAAPLASAAATRRPLPSRDSEFSLPL 652
            |.      |.:.....|.|   ::::||....      ....|.:|
 Frog   357 GH------SQKSPKCVSYKFRIVVNDDGSQEVNNGCRKVKITPCSS------------------- 396

  Fly   653 GRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAK 717
               ||.. |..|.::..:                   :|.:        .|:|.....:|.|||:
 Frog   397 ---MSKG-HSLRSMDPSI-------------------SHQI--------TKRKRMVLIKERKAAQ 430

  Fly   718 TLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRT 782
            |||||||:||||||||||:||:.  |.||||||:.||...|.|||:|||:||:||||||.|||:|
 Frog   431 TLSAILLAFIITWTPYNIMVLVS--TFCSDCIPSSLWHLGYWLCYVNSTVNPICYALCNKTFRKT 493

  Fly   783 YVRILTCKWHTRNRE 797
            :..:|.|:|..:..|
 Frog   494 FKMLLLCRWRKKTVE 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	77/124 (62%)
		7tm_1	121..>314	CDD:278431	114/193 (59%)
chrm5	XP_017952476.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG4220
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1859
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000316
OrthoInspector	1	1.000				T600701
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R2382
TreeFam	1	0.960
	9	8.860