DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and chrm5

DIOPT Version :9

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:XP_017952476.1 Gene:chrm5 / 100498518 XenbaseID:XB-GENE-986590 Length:525 Species:Xenopus tropicalis


Alignment Length:730 Identity:230/730 - (31%)
Similarity:314/730 - (43%) Gaps:246/730 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 NQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAI 148
            |.:|||:..:.    :||..::.:..|:||:|.:|:.||::||:|||::.||:|::||:|.|||.
 Frog     9 NNSNGTVPLKA----HSLWEVITIATVSAIVSLITIVGNILVMVSFKVNSQLKTVNNYYLLSLAC 69

  Fly   149 ADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYR 213
            ||..||..||.|:....::|:|.||.:.||.||||||:||||||:|||:||||||||:|||||||
 Frog    70 ADLIIGIFSMNLYTSYILIGHWSLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 134

  Fly   214 AKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFY 278
            ||||..||.:|||.||.||.:||.|.|..|.|..|.||||.:||.|||: ....||||||:||||
 Frog   135 AKRTPKRAGLMIGLAWFISFILWAPAILCWQYFVGGRTVPPEECQIQFL-YEPIITFGTAIAAFY 198

  Fly   279 FPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDH 343
            .||::|..||.||::||:||.|||..||.                                    
 Frog   199 LPVSVMTILYCRIYKETEKRTKDLAELQG------------------------------------ 227

  Fly   344 DTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFG------SIKEWCI 402
                   |||..|.|                     .::...|:.||  ||.      :.:|.|.
 Frog   228 -------SESVADFE---------------------MMRPQGTLFKS--CFSCKQQTRTKRERCQ 262

  Fly   403 AWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPS 467
            |.|                                 ||.||.|:..|                  
 Frog   263 ASW---------------------------------SSSSRSTTTTV------------------ 276

  Fly   468 ILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNT-SGNGNGAINNNNNASHNGNGAVNGNG 531
                .::.:|..........||...|:..:|...:..| .....||..|...|            
 Frog   277 ----KITHSPNTCNEWIKEDQLTTCSSYPSSDDEDKQTKEAVFQGAYENQTEA------------ 325

  Fly   532 AGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGA 596
                            .::..|..::.:......:.:|....|.                  ||.
 Frog   326 ----------------QKEEETKQILTKEQPGLSNYESERFFLT------------------PGK 356

  Fly   597 GAAASASLSMQGDCAPSIK---MIHEDGPTTT------AAAAPLASAAATRRPLPSRDSEFSLPL 652
            |.      |.:.....|.|   ::::||....      ....|.:|                   
 Frog   357 GH------SQKSPKCVSYKFRIVVNDDGSQEVNNGCRKVKITPCSS------------------- 396

  Fly   653 GRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAK 717
               ||.. |..|.::..:                   :|.:        .|:|.....:|.|||:
 Frog   397 ---MSKG-HSLRSMDPSI-------------------SHQI--------TKRKRMVLIKERKAAQ 430

  Fly   718 TLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRT 782
            |||||||:||||||||||:||:.  |.||||||:.||...|.|||:|||:||:||||||.|||:|
 Frog   431 TLSAILLAFIITWTPYNIMVLVS--TFCSDCIPSSLWHLGYWLCYVNSTVNPICYALCNKTFRKT 493

  Fly   783 YVRILTCKWHTRNRE 797
            :..:|.|:|..:..|
 Frog   494 FKMLLLCRWRKKTVE 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tm_4 117..>241 CDD:304433 76/123 (62%)
7tm_1 121..>314 CDD:278431 114/192 (59%)
chrm5XP_017952476.1 7tm_GPCRs 26..>220 CDD:391938 114/194 (59%)
TM helix 1 28..52 CDD:341315 11/23 (48%)
TM helix 2 61..83 CDD:341315 13/21 (62%)
TM helix 3 99..121 CDD:341315 17/21 (81%)
TM helix 4 144..160 CDD:341315 9/15 (60%)
TM helix 5 186..209 CDD:341315 14/22 (64%)
7tm_GPCRs <423..502 CDD:391938 53/80 (66%)
TM helix 6 426..451 CDD:341315 20/24 (83%)
TM helix 7 462..487 CDD:341315 15/24 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 352 1.000 Domainoid score I1000
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 393 1.000 Inparanoid score I1932
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1245472at2759
OrthoFinder 1 1.000 - - FOG0001308
OrthoInspector 1 1.000 - - otm48994
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2382
SonicParanoid 1 1.000 - - X324
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.100

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