Protein Alignment Fatp3 and ACSL3

DIOPT Version :10

• Sequence 1: NP_726437.2
• Gene: Fatp3 / 37887
• FlyBaseID: FBgn0034999
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 130/596 - (21%)
• Similarity: 217/596 - (36%)
• Gaps: 167/596 - (28%)

  Fly   166 VALLMETRLEYPCIWLGLSQ------LGVITALINSNLRGESLLHSIKVANAKALIVGSELLDVL 224
            :|:..|||.|    |:..:|      ..::|  :.:.|.|.:::|::.......:|...|||..
Human   162 IAIFCETRAE----WMIAAQACFMYNFQLVT--LYATLGGPAIVHALNETEVTNIITSKELLQT- 219

  Fly   225 VSLREKEQLDEVPIYQYT----------DDEVRGVAGHDLLPGAVDLVTALKTQKKLE------- 272
               :.|:.:..||..::.          .:..:|:..|.:.     .|.||..:..:|
Human   220 ---KLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMA-----AVEALGAKASMENQPHSKP 276

  Fly   273 LPSAVCPGEARSKLLYVYTSGTTGLPKAAVITNLRFLFMSAGSYYML-KMSSDDVVYDPLPLYH- 335
            |||.:.        :.:||||:|||||..:|::...:....|....: ::..:||....|||.|
Human   277 LPSDIA--------VIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHV 333

  Fly   336 ----------TAGGIVGV---------GNAILNGS---TVVLRKKFSARNFWLDCDRHNCTVAQY 378
                      :.|..:|.         .:.|..||   |.:|:....|....: .||....|...
Human   334 LELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEI-MDRIYKNVMNK 397

  Fly   379 IGELCR-----YLLATSYSPDQQKH---------------------NLRLMYGNGLRPQIWSQFV 417
            :.|:..     ::||.:|..:|...                     |:||:...|......:|..
Human   398 VSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRF 462

  Fly   418 RR--FGIPHIGEIYGATE--GNSNLINI----TNRVGAIGFVPVYGSSLYPVQVLRCDEYTGELL 474
            ..  |..| :|:.||.||  |...:..:    |.||||               .|.|.|..   |
Human   463 MNICFCCP-VGQGYGLTESAGAGTISEVWDYNTGRVGA---------------PLVCCEIK---L 508

  Fly   475 K--DSKGHCIRCQPGQAG-LLVGKVDARRAVSAFHGYADKGASEQKLLRNVF--TSGDVFFNSGD 534
            |  :..|:....:|...| :|:|      ..|...||.   .:|.|...:.|  .:|..:..:||
Human   509 KNWEEGGYFNTDKPHPRGEILIG------GQSVTMGYY---KNEAKTKADFFEDENGQRWLCTGD 564

  Fly   535 MVVRDILGYFYFKDRTGDTFRWR-GENVATQEVEAIITNCVGLEDCVVY---------GVQIPH- 588
            :...:..|.....||..|..:.: ||.|:..:|||.:.|...:::...|         |..:|:
Human   565 IGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQ 629

  Fly   589 -----VEGKAGMAAI-------VDPERKVDMDYLSVVLRGSLPPYARPLFIRLLDE--IPRTA-- 637
                 :..|.|:...       .:.|.:|........:..||..:..|:.|||..|  .|.|.
Human   630 KELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLV 694

  Fly   638 --TFKLKKREL 646
              .||||::||
Human   695 TDAFKLKRKEL 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:341262	130/596 (22%)
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	130/596 (22%)