|
Fly 14 WNQWILEAISKIRSQKQRPSVQRICQAIGTHHKFHEDIVAEKLEKAVESGAVIKVYNKGLHSYKA 78
:.:||||||.|::.||||||.:|||.|:.:.|......|.|:||.:|:.|.::||.||||:|||.
Mouse 9 YTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRRTVLEQLELSVKDGTILKVSNKGLNSYKD 73
Fly 79 PMAKRRVKVDKNTN-----------LYKLVAKAVHDLGECEGSTIKSIENYIQKFNCIDL----S 128
|....|:.:.|..| ..||:.:|...|.|..|||:||||.:::....:.. |
Mouse 74 PDNPGRIALPKPRNHGKLDTKQSVDWNKLLKRAFEGLAETGGSTLKSIERFLKSQKDVSAACGGS 138
Fly 129 PNVDFKAVIKASIKKAVDAGFLIQEGKLYK--------KGK------------SLTTPRKCAPVS 173
....|...::.:||:||..|.|:::|.||: :|| ||....|..||:
Mouse 139 AAPGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAASAEGKEGCESLSCLPPVSLLPHEKDKPVA 203
Fly 174 EVVIKGEESCTHCSGNSQKNLNGIPEPLSSCKQCGISLHTTCANIAGRCKSQSYVLLYMLVTKGT 238
|.: ..|:.|.|..::|....||.|.||..||.|.|.:|...:.....: .|..
Mouse 204 EPI----PICSFCLGTKEQNREKQPEELVSCADCGNSGHPSCLKFSPELTVR---------VKAL 255
Fly 239 IWDCQNCADCAVCKMRNR-GPCLLQCFVCKDHFHLTCLDTIPDKKPKHPYRCKTC--SKQGFDTP 300
.|.|..|..|:.|:.:.: ...:|.|..|...||:.|.|....:.||..:.|:.| .|:| .
Mouse 256 RWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKG---R 317
Fly 301 KLVKKDNSRIKMEAERMTPSYKYAS---NKRQSIKKDGNIESPSTSKLCVYNDGNGQRRKVPASL 362
||::|..::||. :||: ..:..:||...:.....||:.. ..|.|::||:
Mouse 318 KLLQKKAAQIKR---------RYANPIGRPKNRLKKQNTVSKGPFSKVRT-GPGRGRKRKI---- 368
Fly 363 SSRKMNHSEDQFEFPSKQKRSQILQGGYLASQETRKRTFSDLSSTSSSSESEDEDDEDDDRNRNG 427
Mouse 369 ----------------------------------------------------------------- 368
Fly 428 DDNDQDESTSSDSCTSSSSDSDSSESSSDTSEWDDEYDEEEDYDTDRSTIREKNVFESGKQSCAK 492
:.||.|.:|| ||.|
Mouse 369 -------TVSSQSASSS----------------------EEGY---------------------- 382
Fly 493 LSTGDGLGSPQNNELGSENWGFAAVAKNPIDIFVKSKHNSNVKGI--GYSKPAASTFATSPAANR 555
|...||| .|...:..|: |.|...||: |.:| .|..||
Mouse 383 LERIDGL-------------DFCRDSNAPL------KFNKKTKGLIDGLTK----FFTPSP---- 420
Fly 556 VQKSTPVASSTPEKNSAPIGGMTIKRQTANGQKKKIVPLKSMPLEAGKSYEKCEDDIPYLTEETV 620
:|:|.: |
Mouse 421 -----------------------------DGRKAR-----------G------------------ 427
Fly 621 MKVQLLEEIERSRETHSQADGKREMNND----EDAPGESTKRANP---FENQPLPPGVTATDVEL 678
|.::.|.:...:..|.|:.:.. ::..|..:|:.|. |.:|.: :|..|:||
Mouse 428 ------EVVDYSEQYRIRKKGNRKSSTSDWPTDNQDGWESKQENEERLFGSQEI---MTERDMEL 483
Fly 679 YQEVLHKAVVQMSNNHIEKVNDVSLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLC 743
::::..:| ::||. |:.......:.|..|:.||::|.||||||:||||:||.||:||
Mouse 484 FRDIQEQA--------LQKVG-VTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC 539
Fly 744 EFCLKYTKSRSVLDRHQNKCIWKQPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKT 808
||||||.|||::|.:|..||.|..||..||:|:.|||||||||||:.|||||||||||.||||||
Mouse 540 EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKT 604
Fly 809 LYYDVEPFLFYILTKNDQSGCHLVGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLS 873
|||||||||||:||:||..||||||||||||||.||||||||:.:|||||:||||||||||||||
Mouse 605 LYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLS 669
Fly 874 REEGQLGTPEKPLSDLGRLSYFSYWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELL 938
:.|||.|:|||||||||||||.:|||||:||.|| |:|..:|:.|.::..||:...||......|
Mouse 670 KREGQAGSPEKPLSDLGRLSYMAYWKSVILECLY-HQNDKQISIKKLSKLTGVCPQDITSTLHHL 733
Fly 939 NFIKLRKNDGDIRYQINVKIEWKKVLAHH-NKMANSKTRIIIEPDCLRWSPLLSVSKLPNIIKPI 1002
..: |.|....|.|..:|::..| .|:..:...:.::|:||||:|:: ||. :::...
Mouse 734 RML-------DFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVI-VSN--SVVSED 788
Fly 1003 SNREYLSNQMETNSSFKEINEDKISVKQGVSTSSKVNQESSELSTKNRGPSSEKLIDERENQRKR 1067
.:.|....:.|.....:...|.::.|.:.||...| :||||.|...::.|..::|... ....|:
Mouse 789 EDEEADEGEKEEPQGQERELETRVKVGKSVSREKK-DQESSSLIETDKKPEVKELASS-SRLSKQ 851
Fly 1068 AYPEEFLKSASNEAKKPKLTAPQPNLEDQSFGE----------LSDS----SDCKSSKDLSE--- 1115
|.|.:.|.:.|...::.:........::: ||: ||.| .||:...:.|:
Mouse 852 ALPRDSLPANSQPPRRGRCGRKNRKTQER-FGDKDSKMLVDETLSASQEQYGDCEEKSETSQERF 915
Fly 1116 ----------------------------------QLTKRAQ----RLAKRNDLIP---------- 1132
||.|..: ||.:.||.:|
Mouse 916 TEMEEQLAAPQVQADGKPDIPKGRFSESVELWRGQLKKSPETLKCRLPEGNDRLPCCYTDGDRAV 980
Fly 1133 -----------------------------------------HTNKRKHFDRPLENNTTSTDHNPP 1156
...||||.:..:...|.|......
Mouse 981 FRGFSESSEEEEEPESPRSNSPPILTKPTLKRKKPILHRRRRVRKRKHHNSSVVTETISETTEVL 1045
Fly 1157 AQSQADTAGTENGHKSEETAAKENCKNVVEKEHVDKPVNIMPK-----------LRGKQSNGKRS 1210
.:...|:.......:.|.|...|. |:|..::...:.|: ||.:.|:.:.|
Mouse 1046 DEPFEDSDSERPMPRLEPTFEMEE-----EEEEEEEESELFPRGYFHCLSSQDILRCQSSSKRPS 1105
Fly 1211 EEPQFNENPTSD--------PVAV--------ASLSPAKEITREPVKVAKTESPGKNQESAKHDA 1259
:|.:..|..:.| ||:: |||.|. |..|:|..|....||:::......
Mouse 1106 KEEEEEEEESDDADDTPVLKPVSLLRKCDVNSASLEPD---TSTPMKKKKGWPKGKSRKPIHWKK 1167
Fly 1260 EPNSVSDQVLDAVAKKTKKTLFSDVASYNTEDVKYNSEEKPMAIAQEPKESPTEAGIKETKPLEV 1324
.|. :|..| |.|.| .||...:|...|..: |::
Mouse 1168 RPG--------------RKPGF-----------KLNQE----IIAASAQECIVEPVV----PIK- 1198
Fly 1325 PEQKAKAKSPEKPATVAETVLQHVHAPVNT---EKISTEESKLELDVHYLKLSPDSALNPPVASV 1386
|.:|.:.:..|:...|.|.:|:.....::| |:...||.....|:. .:||..:.|.|.|..
Mouse 1199 PGRKPRTQENEEIVEVKEDLLEERKEEMHTEPDEEAEEEEDTTSSDIR--AMSPLDSSNSPEAEP 1261
Fly 1387 QKPVPEPPAPKEKAKDLQAAQPSEALQKQPEIEMVKKTETKTETPVSNPPSNRTD-----VSSL- 1445
:: |||....||..|.| .|..|..|:..|.|..::.|..||.. .|...:..| :.||
Mouse 1262 KE--PEPEEEDEKPSDDQ-RQSEEEPQELEEQEQEEEDEVTTEAN-QNEDHDADDEDEGHLDSLK 1322
Fly 1446 ----VEQPVKAAPEKVEQP----------MVKEAVDIKDKALKKPVPDVPVVKPEATSCEKKIDH 1496
.||| |..:..|:| |.....:.|||...:|..:......||:...:.:..
Mouse 1323 TKEPEEQP--AREDDKEEPGIQGSFLAANMQDSRENTKDKDEAEPDSEEDQPSHEASVVSETMPG 1385
Fly 1497 SKTKVFHEKEAIKTDQQLVQVKEEEKSNARAPSAPIPIRDKIQLKGNEHAQLQ-NSIPSQFPLNQ 1560
|:.. ||::: .|.::|:::||||: || |::|. .::.:...|.|
Mouse 1386 SEED--HEEDS-NTKEELIELKEEEE---------IP-----------HSELDLETVQAVQSLTQ 1427
Fly 1561 -MPNYHTSQYWQWEYYGYNLSHLDASQKGQKQFHKDLATTMAYTHNFTQNLYQSANLAMQHAHHQ 1624
..:.|...|...| ..|.|.| |..:|||. ....|
Mouse 1428 EESSEHEGAYQDCE------ETLAACQ-----------TLQSYTHT--------------DEDPQ 1461
Fly 1625 MHQTKEKHKVERKNSGKKEEQNKVVSSVNVVSTAREDAHVQHCNEYAANNQAALYNQKCASQQKQ 1689
|...::.| ..|.|..:||: .:| .
Mouse 1462 MSMVEDCH---------ASEHNSPISSI--------PSH-------------------------P 1484
Fly 1690 AQQMKSLANVQNPV---------PRQSNSNAP-----ESTVLMPNPVISQAGSVPAKQKVEHGVN 1740
:|.::|:.:...|. |.|.:.:|| |::.:|..|.:|. .::|.|:.|.:
Mouse 1485 SQSVRSVNSPSMPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSD----HSQQVVDSGFS 1545
Fly 1741 STSVISREGKLNKIGHSNIHATAQHANLQVGGGQSDVNPNMVYNTESSANSAMQHYDCGISAQIN 1805
.. .:|.:|.:: |...||.:|.|....|| |
Mouse 1546 DL--------------GSIESTTEN-----------------YENPSSYDSTMGSSICG-----N 1574
Fly 1806 MDSPANIGSAIAHGPQEISATSNVHMHQPHRQFSDCSMQNQPVTTPMHMSIQNS-HMQQQNNLNL 1869
..|. |:.::| .:|::|:: .||..|.|....::.|| .|.|||.:.
Mouse 1575 NSSQ----SSCSYG--GLSSSSSL-------------TQNSCVVTQQMANMGNSCSMLQQNTVQ- 1619
Fly 1870 NLAPEGSSNINLLSNPQHQHQSRKLNAQADIAVSSPTPSHRATTPKQIRSGNTQQRDAKNAAPPT 1934
|..:.|| .:||.....|..:.| .|.|......|.|......||:.|....||.
Mouse 1620 ---PAANCNI---KSPQTCVVERPPSNQ------QPPPPPPPPPPPQQPQPPPQQQAAPQPPPPQ 1672
Fly 1935 TTTNTHHQIPQGGAAANISKSHHDSLHNLQFSQHGHQQNMQPIDYVPIPQISQNFSANPSNYDIV 1999
.|...||..|| |.|| ..|
Mouse 1673 -------------------------------PQQQQQQQQQP----PPPQ------QQP------ 1690
Fly 2000 GMPAVIQQRMSLNGSVHSLANSHQRIEQPSSACAVNNFYLQNNMPAAENAPRVPVSSSLGGPPTA 2064
.|...|| :.|.|.|::| |:..||.....:|.|.|.|.....
Mouse 1691 -QPPPPQQ------------------QPPLSQCSMN-----NSFTAAPMIMEIPESGSTGNISIY 1731
Fly 2065 GNNDQRQAGQDSITTANSSGATASLAGNLCSLSKLQQLTNCL--------ESQPCNTSPGAQVNL 2121
:|..|.....:.:...||.||| |||||||.: ...|..||....|:|
Mouse 1732 ----ERIPGDFGAGSYSQPSATFSLA-------KLQQLTNTIMDPHAMPYSHSPAVTSYATSVSL 1785
Fly 2122 AP------SPHHPI--PPNS----TPPPHLLMQNRNISTP---PNMLQTQVTPLQYKYYPGNMNI 2171
:. :|.||: .|.: ||||:|.....|:::| .||..|.:.....:...|.|.:
Mouse 1786 SNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPV 1850
Fly 2172 P------------PITSAQNTSRNTRNTPSAPVQHTSTPMGSGNNRTANVHISP----NL----M 2216
. |..:|.......|:.|:..:|.....:.........|::.| |: |
Mouse 1851 KGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNM 1915
Fly 2217 APYGAINSYRMSPQQSPPTGSYSSGGDYPN--SQIPMQMM--NMQSQYQDACVLQRGTPSNPMY- 2276
....|:|||||: |.....||.|...|.| :|.||||. .|.||......:|.....|.||
Mouse 1916 NTLNAMNSYRMT--QPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYT 1978
Fly 2277 -PTYSPYL--------PLNGSIRR 2291
|::..|: .|||...|
Mouse 1979 GPSHHSYMNAAGVPKQSLNGPYMR 2002
| 
