Protein Alignment Rsph4a and RSPH4A

DIOPT Version :10

• Sequence 1: NP_611869.1
• Gene: Rsph4a / 37831
• FlyBaseID: FBgn0034957
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: NP_001010892.1
• Gene: RSPH4A / 345895
• HGNCID: 21558
• Length: 716
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 228/758 - (30%)
• Similarity: 340/758 - (44%)
• Gaps: 196/758 - (25%)

  Fly    13 STSSSHFAP-------PP------VCAPRRKKPEKPAAEEASPECSNV---TSSSSSSTTTIS-- 59
            |:|.|..||       ||      ...|....|.....|::|.:..:.   ||.|..:|...|
Human    91 SSSPSPLAPARQDLAAPPQSDRTTSVIPEAGTPYPDPLEQSSDKRESTPHHTSQSEGNTFQQSQQ 155

  Fly    60 -----IGAFDSQCNLHNARNPEA---------PNIGYELNV-------------------AKSIL 91
                 .|..|...|  ||:..|.         .|..|:|..                   ||:.|
Human   156 PKPHLCGRRDVSYN--NAKQKELRFDVFQEEDSNSDYDLQQPAPGGSEVAPSMLEITIQNAKAYL 218

  Fly    92 QKYSTLSGDNLFDHLSDIIKRVIDERPPNVIDFFEEFSRNVREQKFHLPERFPPSGVFDEVR--- 153
            .|.|:.||.||:||||:::.::::|||.|.:|.||..|::|:...|        |..||.::
Human   219 LKTSSNSGFNLYDHLSNMLTKILNERPENAVDIFENISQDVKMAHF--------SKKFDALQNEN 275

  Fly   154 ----SFRVAKKILQSMKLPYVVEGEDLMGEDLSVEDLRTNEDMRIVIDDSMRYFVTFNERVQQLQ 214
                ::.:|:| .:::.|...:||.|...||...|:...|                    |.:..
Human   276 ELLPTYEIAEK-QKALFLQGHLEGVDQELEDEIAENALPN--------------------VMESA 319

  Fly   215 FYWTQCGFSISNDDIFQLASAMNRL-QTHPSIMQCRFWGCINGLKASYYIVEASLTREEIASRLV 278
            ||:.|.|..:..|:.:::..|:.:| .||| |.:|||||.|.||:.:|.:.|......|
Human   320 FYFEQAGVGLGTDETYRIFLALKQLTDTHP-IQRCRFWGKILGLEMNYIVAEVEFREGE------ 377

  Fly   279 MMEEEMRQKQIPFPMRKDREDKPPPAHIGPELTPGIYGWEEFPPEELEKMKPKAAPVPLVEEMEL 343
             .|||:.::.:    .::|::....||             |...:||.|...||...
Human   378 -DEEEVEEEDV----AEERDNGESEAH-------------EDEEDELPKSFYKAPQA-------- 416

  Fly   344 YDIPPEFIGKGCNRYSYFVVNSLFDDWIELPIVTPRQIVVSRQIKKFLTGDLEADVISYPCFPGK 408
              ||.|....|.|:|.|||.|.....|::||.|.|.|||::|:||||.||.|:|.:||||.|||.
Human   417 --IPKEESRTGANKYVYFVCNEPGRPWVKLPPVIPAQIVIARKIKKFFTGRLDAPIISYPPFPGN 479

  Fly   409 EKHYLRTLIGRITAGTYIAPVGYYRRMTKKEQRMFDGEEEEEGEEEEEEEEEEEFNEGEEEQIED 473
            |.:|||..|.||:|||:::|:|:|                :.||||.|||||.   ||.....|:
Human   480 ESNYLRAQIARISAGTHVSPLGFY----------------QFGEEEGEEEEEA---EGGRNSFEE 525

  Fly   474 NDVMLLKNEKYEAEPLGSLATPVA-WVHVRSNILNQQGRVVWYDEEKARKEREKALALYLKMQML 537
                   |..:|...:..|...:: |||...:||: |||..|::..
Human   526 -------NPDFEGIQVIDLVESLSNWVHHVQHILS-QGRCNWFNSI------------------- 563

  Fly   538 GEMEEEVEEEEDEEEGEEEGEEEGMIEGFNQPELGPSILSSCANDMNPEVPVSWLARMTSKYTNQ 602
             :..||.|||||||:.:.:         :.:.|:|..:|:..:.|:..:....|..|::|....|
Human   564 -QKNEEEEEEEDEEKDDSD---------YIEQEVGLPLLTPISEDLEIQNIPPWTTRLSSNLIPQ 618

  Fly   603 KERMLVMQSNVWPGAYTFIFEKTCESIYLGWGHKY----YARNIPFKHLPMVQEEFPHNPEDFVE 663
             ..:.|:|||:|||||.|...|..|:.|:||||||    |...:|    |.|.:|:|..|| ..|
Human   619 -YAIAVLQSNLWPGAYAFSNGKKFENFYIGWGHKYSPDNYTPPVP----PPVYQEYPSGPE-ITE 677

  Fly   664 ANDPTVEEEEAYKAWLLRKQQKAEYVAEDIEDYDDDEFADQYD 706
            .:||:||||:|::|    .|:.....||:.|..:|::..|.||
Human   678 MDDPSVEEEQAFRA----AQEAVLLAAENEESEEDEDEEDDYD 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rsph4a	NP_611869.1	Radial_spoke	87..637	CDD:461405	176/558 (32%)
RSPH4A	NP_001010892.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..164		17/72 (24%)
		PRK07764	<18..217	CDD:236090	27/127 (21%)
		Radial_spoke	214..652	CDD:461405	176/558 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..410		11/58 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..526		12/29 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..716		5/18 (28%)