DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pask and PASK

DIOPT Version :9

Sequence 1:	NP_611864.1	Gene:	Pask / 37824	FlyBaseID:	FBgn0034950	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001239048.1	Gene:	PASK / 23178	HGNCID:	17270	Length:	1330	Species:	Homo sapiens

Alignment Length:	1219	Identity:	335/1219 - (27%)
Similarity:	488/1219 - (40%)	Gaps:	418/1219 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSSSNAQCSRNRC----ANDDPIMGSHSQS-----RQNSSGMLNMMDASSFSMPPPNLHSSKVIN 70
            |::.|...|:..|    .:.||.....|.|     |..|||.      ||..:|.|      |.|
Human    77 LAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGW------SSPLLPAP------VCN 129

  Fly    71 PNKAIFTIDANTGQIFIVNNKACQLLGYTSQELRNKGFFDLLNGKTESHISSLAEMQIEGDEGRV 135
            |||||||:||.|.:|.:.|:|||.||||:||:|..:.............:.:|:|..:|.| |..
Human   130 PNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEAD-GHA 193

  Fly   136 VLLSGKVIEMKTKSGGKILVSLWIRQISSDGR--HIAVAEPVERHICHISTDRSGVITSVDSTTA 198
            .::.|.|:::.::||.||.||:|::::..:.|  .:.|.|||||....::....|.:||.||..|
Human   194 AVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFA 258

  Fly   199 TIFFYESVESVVGVSIVTLIPFIKLPDPDSREIPKSLRKQRATGRTTDNVKFPLCLLI---ALDE 260
            .:..|.|.|.|.|..|..|||.::|| |..:.|||:|:.||:.||..|...|||.|.:   ...|
Human   259 HLHGYVSGEDVAGQHITDLIPSVQLP-PSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSE 322

  Fly   261 DASAGYSHSGKTGLNITVWVFQNLSGLIVVDDIGNILMCNQPFSLLMFGYGQDKIMNMHISAILP 325
            :|:.|.: :..:|...:||||..:||||.:...|.|...|..|:|.:||||:.:::..:|:.::|
Human   323 EATTGEA-APVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIP 386

  Fly   326 NF---------------------------------------------GKDSR------------- 332
            .|                                             |:|.|
Human   387 GFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPR 451

  Fly   333 -------------------------------EEKSPNVSNT-----------------SITS--- 346
                                           .:.:|.|.|.                 .||:
Human   452 DEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGR 516

  Fly   347 ----------------------------------------------------------------- 346

Human   517 EEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGP 581

  Fly   347 ---------------------------------NDW----------------------EPDTDP- 355
                                             ::|                      .|..|.
Human   582 SGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEP 646

  Fly   356 -LVVDND-SSLQSCK-KSSTNR----------------------TAPNN---------------- 379
             |.|:|| ..||:|. |...::                      |||.:
Human   647 WLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGS 711

  Fly   380 ------------------EQSSVGDAHLSCNL----------ENSSGLFC---DLRQ-------- 405
                              |...|.....|.||          :.||...|   :||:
Human   712 SSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVG 776

  Fly   406 --PD--------DCTIDD----ILT----PVNASNSF--------PADEFEVGSQSQVNESSLDK 444
              ||        .|.:||    :||    .:.....|        |.:..||...|..:.::.|:
Human   777 SDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDR 841

  Fly   445 AK---------SASTETCDAS---------GSNP------ATRLLSSI-NGSFVGEAIHADGSVI 484
            ..         :...:||.::         .|.|      |..|...| .|::.|...|.||..:
Human   842 ESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRL 906

  Fly   485 EVVYSVLLQILPCSNRVYCIWVCRN---------PSTRLDGEKYNYANLT-STFNSMASTVEQSL 539
            .:.:.|....|.....::|.|:.::         ..|||     ..|:|. ||.::.|.....||
Human   907 SIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRL-----FLASLPGSTHSTAAELTGPSL 966

  Fly   540 GQVIKTTAAQNSSRPNSLSLVSKYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVIT 604
            .:|:: ........|.::.|......|   |:||:.|:::..:|.||:|:|..|........|:.
Human   967 VEVLR-ARPWFEEPPKAVELEGLAACE---GEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVV 1027

  Fly   605 KFILKEKLCSQFMVKSRDCKEVPIEIHLLQTLNHKNIVSVLDVFENDLFYQLVMEKHGSGMDLWT 669
            |||.|||:.....::.....:|.:||.:|..:.|.||:.|||:|||..|:||||||||||:||:.
Human  1028 KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFA 1092

  Fly   670 FIERRPLMDEKLGSYIFRQV-------ADAVNYLHEQKILHRDIKDENIIIDQNFTIKLIDFGSA 727
            ||:|.|.:||.|.|||||||       ..||.||..:.|:|||||||||:|.::|||||||||||
Human  1093 FIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSA 1157

  Fly   728 TFMEEGKFFSTFYGTTEYCSPEVLAGNRYVGPELEIWALGVTLYVLMFFENPFIDVEETLKAEIQ 792
            .::|.||.|.||.||.|||:||||.||.|.|||||:|:||||||.|:|.||||.::|||::|.|.
Human  1158 AYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIH 1222

  Fly   793 IPKAVSEQLSRLLSSMLNKDPKYRCTMHQLITDPWLTQEVNPSTFSFSW 841
            .|..||::|..|:|.:|...|:.|.|:.:|:||||:||.||.:  .::|
Human  1223 PPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLA--DYTW 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS_9	74..169	CDD:290162	34/96 (35%)
		PAS	74..169	CDD:238075	34/96 (35%)
		PAS_9	286..>335	CDD:290162	18/137 (13%)
		PAS	286..>325	CDD:238075	13/38 (34%)
		STKc_PASK	575..828	CDD:270906	135/259 (52%)
		S_TKc	576..828	CDD:214567	135/258 (52%)
PASK	NP_001239048.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..47
		PAS_9	133..232	CDD:290162	34/99 (34%)
		PAS	133..232	CDD:238075	34/99 (34%)
		PAS	344..401	CDD:214512	16/56 (29%)
		PAS_9	347..>386	CDD:290162	13/38 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..857		1/19 (5%)
		STKc_PASK	998..1258	CDD:270906	135/259 (52%)
		S_TKc	999..1258	CDD:214567	135/258 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1305..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152437
Domainoid	1	1.000	280	1.000	Domainoid score	I1698
eggNOG	1	0.900	-	-		E2759_KOG1152
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1501
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153824at33208
OrthoFinder	1	1.000	-	-		FOG0004753
OrthoInspector	1	1.000	-	-		oto91630
orthoMCL	1	0.900	-	-		OOG6_104334
Panther	1	1.100	-	-	LDO	PTHR24346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2244
SonicParanoid	1	1.000	-	-		X5095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790