Protein Alignment PPP1R15 and PPP1R15B

DIOPT Version :10

• Sequence 1: NP_611863.1
• Gene: PPP1R15 / 37820
• FlyBaseID: FBgn0034948
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_116222.4
• Gene: PPP1R15B / 84919
• HGNCID: 14951
• Length: 713
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 60/298 - (20%)
• Similarity: 92/298 - (30%)
• Gaps: 128/298 - (42%)

  Fly    67 PEDLRI--PTLQPDPLNPLATMMSFKLMAMDVVTQMQTALHKCVNAQSPPGAKMAGIELDALRRC 129
            ||.|.:  .....||.||           .:....:|||                       .|.
Human   472 PEGLHLWNSFCSVDPYNP-----------QNFTATIQTA-----------------------ARI 502

  Fly   130 VPSSCYFFIDLHPHHGFKDTAEDCPTSQASSDRNNNAGCSQGSAAKSSWQRQRSISECSEDSFIC 194
            ||.        .|....||.:       ..||..|::  ..||..::.   :.|..|
Human   503 VPE--------EPSDSEKDLS-------GKSDLENSS--QSGSLPETP---EHSSGE-------- 539

  Fly   195 FEDDAEQADEDVEEDE------DDDDDDSSVQFTA----CGEDENTEELKACQCSDDSSTPVKKV 249
             |||.|.:.::.|..:      :.||..:.:.|.|    .||:|     |.|:   ||.||.:.:
Human   540 -EDDWESSADEAESLKLWNSFCNSDDPYNPLNFKAPFQTSGENE-----KGCR---DSKTPSESI 595

  Fly   250 RFNMKPEVHVMLAWDYAYRAARKSE---------------------------------------- 274
              ....|.|.:|:.......:::||
Human   596 --VAISECHTLLSCKVQLLGSQESECPDSVQRDVLSGGRHTHVKRKKVTFLEEVTEYYISGDEDR 658

  Fly   275 ---WQVMARDRDRFQQRIRRISPILNAVLTPVHRDRVY 309
               |:..|||..|||:||:.....:...||..||:|::
Human   659 KGPWEEFARDGCRFQKRIQETEDAIGYCLTFEHRERMF 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP1R15	NP_611863.1	PP1c_bdg	<242..312	CDD:431311	22/111 (20%)
PPP1R15B	NP_116222.4	CReP_N	1..410	CDD:371074
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..53
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	376..398
		PP1c_bdg	413..699	CDD:431311	60/298 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..472		60/298 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..548		16/74 (22%)