Protein Alignment Galphas and GNA14

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_004288.1
• Gene: GNA14 / 9630
• HGNCID: 4382
• Length: 355
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 153/371 - (41%)
• Similarity: 213/371 - (57%)
• Gaps: 24/371 - (6%)

  Fly    16 SEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKI 80
            |.:.|..:|.|..|.|||::||:..|...:|||||.|||||||.:|||||:|..|:||.::|...
Human     8 SAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFT 72

  Fly    81 DDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYEHTEELWKDK 145
            ..:.:||..|:..:..||.||......|  :|:...:.|::...........|..|..::||:|.
Human    73 KLVYQNIFTAMQAMIRAMDTLRIQYVCE--QNKENAQIIREVEVDKVSMLSREQVEAIKQLWQDP 135

  Fly   146 GVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMF 210
            |:.:.|:|..||||.|.|||:|..:..|..|::.|.:||:||.||.|:||.|..|.::.:.|.|.
Human   136 GIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMV 200

  Fly   211 DVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISI 275
            ||||||.||||||.||..||:|||:.|.|.|:.||.|...:||:.||..|||:|....|....|:
Human   201 DVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSV 265

  Fly   276 ILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRI- 339
            ||||||:|||.|||.  .|.|..||.|:        ||        ..:.:||   .||..|::
Human   266 ILFLNKKDLLEEKIM--YSHLISYFPEY--------TG--------PKQDVRA---ARDFILKLY 309

  Fly   340 STASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            ...:.|.:...|.|||||.||:||:.||...:|.|.:::||::.|:
Human   310 QDQNPDKEKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLREFNLV 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	139/335 (41%)
GNA14	NP_004288.1	G-alpha	36..349	CDD:206639	139/335 (41%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	37..50		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)