Protein Alignment Galphas and Gnao1

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_034438.1
• Gene: Gnao1 / 14681
• MGIID: 95775
• Length: 354
• Species: Mus musculus
• Alignment Length: 385
• Identity: 165/385 - (42%)
• Similarity: 209/385 - (54%)
• Gaps: 41/385 - (10%)

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||          ..|.:.::...||.||.:.|::|........:||||||||||||||||||:|
Mouse     1 MGC----------TLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKI 55

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNY 130
            :|.||||..:.||....:..|...::..|..||.||.  |....||.:...:.:.|..|..:...
Mouse    56 IHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLG--VEYGDKERKTDSKMVCDVVSRMEDTE 118

  Fly   131 P--PEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTS 193
            |  .|.......||.|.|:.:.:.||.||||.|.|||:||.:..|...:|.|.||||||.||.|:
Mouse   119 PFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTT 183

  Fly   194 GIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESL 258
            ||.||.|....::|.:|||||||.||:|||.||.|||||||..|.|.|:.||.||.|.||:.|||
Mouse   184 GIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESL 248

  Fly   259 DLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEF---NKYQTPIDTGDAIMESN 320
            .||.||.||::....||||||||:||..||||  ||.|:..|.|:   |.|:.
Mouse   249 MLFDSICNNKFFIDTSIILFLNKKDLFGEKIK--KSPLTICFPEYPGSNTYED------------ 299

  Fly   321 DDPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380
                   |..:|:.:| .....|.:.:.||  |.|||.||.||:.||:...|||...:||
Mouse   300 -------AAAYIQTQF-ESKNRSPNKEIYC--HMTCATDTNNIQVVFDAVTDIIIANNLR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	153/339 (45%)
Gnao1	NP_034438.1	G-alpha	34..348	CDD:206639	153/339 (45%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)