Protein Alignment Galphas and Gnai2

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_032164.2
• Gene: Gnai2 / 14678
• MGIID: 95772
• Length: 355
• Species: Mus musculus
• Alignment Length: 383
• Identity: 156/383 - (40%)
• Similarity: 213/383 - (55%)
• Gaps: 36/383 - (9%)

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||         .|::|| |:...||..|.:.|::|.:......:||||||||||||||||||:|
Mouse     1 MGC---------TVSAED-KAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKI 55

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNY 130
            :|.||:|:.|.:|....:..|...:|:.|..||..|....|..::.::.|..:....|:......
Mouse    56 IHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPQRADDARQLFALSCAAEEQGML 120

  Fly   131 PPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGI 195
            |.:.......||.|.||...:.||.||||.|.|.|:|:.:..|...:|.|.:||:||.||.|:||
Mouse   121 PEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGI 185

  Fly   196 FETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDL 260
            .||.|....::|.||||||||.||:|||.||..||||||..|.|:|::||.||...||:.||:.|
Mouse   186 VETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKL 250

  Fly   261 FKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEF---NKYQTPIDTGDAIMESNDD 322
            |.||.||:|....||||||||:||..|||.  :|.|:..|.|:   |||.
Mouse   251 FDSICNNKWFTDTSIILFLNKKDLFEEKIT--QSSLTICFPEYTGANKYD--------------- 298

  Fly   323 PEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380
                .|..:|:.:|..::... |.|. .|.|||||.||:|::.||:...|:|.:.:|:
Mouse   299 ----EAASYIQSKFEDLNKRK-DTKE-IYTHFTCATDTKNVQFVFDAVTDVIIKNNLK 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	143/337 (42%)
Gnai2	NP_032164.2	G-alpha	34..349	CDD:206639	143/337 (42%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)