DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and DNL4

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_014647.1	Gene:	DNL4 / 854166	SGDID:	S000005531	Length:	944	Species:	Saccharomyces cerevisiae

Alignment Length:	730	Identity:	166/730 - (22%)
Similarity:	280/730 - (38%)	Gaps:	151/730 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 ENYDPSADSYHPLKNAYWKDKKV----TPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSP 162
            :|:.||.|.....:..:.|..:|    |.....:|:|          |..:.:|||.........
Yeast    12 QNFAPSPDFKWLCEELFVKIHEVQINGTAGTGKSRSF----------KYYEIISNFVEMWRKTVG 66

  Fly   163 EDLVPSVYLSINQLAPAYEGLELGVAETTLMKAIC--------KATGRNLAHIKSQTQLTGDLGI 219
            .::.|::.|::    |..:.....:.:..|::.||        .||.:.|...|.:....|:|..
Yeast    67 NNIYPALVLAL----PYRDRRIYNIKDYVLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNLSS 127

  Fly   220 VAEQSRVSQRMMFQPAPLNVRDVFRKLREIAK---LSGQSKMDLVYNM-FVACRSS----EARFF 276
            :..:....:|.......:.:.:|...|..::.   .||:....||.:. |:.|..:    |.::|
Yeast   128 LLVEEIAKRRAEPSSKAITIDNVNHYLDSLSGDRFASGRGFKSLVKSKPFLHCVENMSFVELKYF 192

  Fly   277 IRSLIGKLRIGIAEQSLLTALAIGLVKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYD 341
            ...::....||..|..||...        |.|   |.....|..|..|.|:.|          ||
Yeast   193 FDIVLKNRVIGGQEHKLLNCW--------HPD---AQDYLSVISDLKVVTSKL----------YD 236

  Fly   342 IIIPAI-LKYDIKELQERCPMHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHR 405
               |.: ||.|...::      .|....|.||:.....:|...|........|.|.||||.|:|.
Yeast   237 ---PKVRLKDDDLSIK------VGFAFAPQLAKKVNLSYEKICRTLHDDFLVEEKMDGERIQVHY 292

  Fly   406 NEKGE-ISIFSRNSENNTAKYPDLIARST----ALLKGDVKSYIIDSEIVAWDVERKQILPF--- 462
            ...|| |..|||...:.|..|...::..|    ......||..::|.|:|.:|.:|:.||||
Yeast   293 MNYGESIKFFSRRGIDYTYLYGASLSSGTISQHLRFTDSVKECVLDGEMVTFDAKRRVILPFGLV 357

  Fly   463 -----QVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKF 522
                 :.||.....|||...:.:     :|||||:|||:|....|.:|::.|......::...:.
Yeast   358 KGSAKEALSFNSINNVDFHPLYM-----VFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKNIVEI 417

  Fly   523 ATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLV 587
            ..:.....::.:::.||.:|....||:::|..:  ::|.:|.|:.||:|:|.:||...|::|||:
Yeast   418 VRSSRCYGVESIKKSLEVAISLGSEGVVLKYYN--SSYNVASRNNNWIKVKPEYLEEFGENLDLI 480

  Fly   588 VIGGYKGKGRRTGTYGGFLLACYDTENEEYQ------------------------------SICK 622
            ||      ||.:|....|:|.....:.|||:                              |.|.
Yeast   481 VI------GRDSGKKDSFMLGLLVLDEEEYKKHQGDSSEIVDHSSQEKHIQNSRRRVKKILSFCS 539

  Fly   623 IGTGFTDE-----DLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQ--VWEVKCADLSLSP 680
            |..|.:.|     |.:|...:......:...|...:...: |..|.:|.:  |.|:|...|..:.
Yeast   540 IANGISQEEFKEIDRKTRGHWKRTSEVAPPASILEFGSKI-PAEWIDPSESIVLEIKSRSLDNTE 603

  Fly   681 IHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNN------------ 733
            .:.....     ...:|......|||.||   ..||...:..:|:|: .||:|
Yeast   604 TNMQKYA-----TNCTLYGGYCKRIRYDK---EWTDCYTLNDLYESR-TVKSNPSYQAERSQLGL 659

  Fly   734 -QKSSTQMEMEDEFY 747
             :|...::.:.|.|:
Yeast   660 IRKKRKRVLISDSFH 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	164/726 (23%)
		DNA_ligase_A_N	126..292	CDD:282522	32/181 (18%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	64/230 (28%)
		OBF_DNA_ligase_I	581..726	CDD:153438	38/181 (21%)
DNL4	NP_014647.1	DNA_ligase_A_N	20..207	CDD:282522	34/200 (17%)
		dnl1	84..717	CDD:273147	150/644 (23%)
		Adenylation_DNA_ligase_IV	244..471	CDD:185713	66/239 (28%)
		OBF_DNA_ligase_IV	474..635	CDD:153437	37/175 (21%)
		BRCT	681..767	CDD:278934
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810