Protein Alignment DNAlig1 and DNL4

DIOPT Version :10

• Sequence 1: NP_611843.2
• Gene: DNAlig1 / 37791
• FlyBaseID: FBgn0262619
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_014647.1
• Gene: DNL4 / 854166
• SGDID: S000005531
• Length: 944
• Species: Saccharomyces cerevisiae
• Alignment Length: 730
• Identity: 166/730 - (22%)
• Similarity: 280/730 - (38%)
• Gaps: 151/730 - (20%)

  Fly   102 ENYDPSADSYHPLKNAYWKDKKV----TPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSP 162
            :|:.||.|.....:..:.|..:|    |.....:|:|          |..:.:|||.........
Yeast    12 QNFAPSPDFKWLCEELFVKIHEVQINGTAGTGKSRSF----------KYYEIISNFVEMWRKTVG 66

  Fly   163 EDLVPSVYLSINQLAPAYEGLELGVAETTLMKAIC--------KATGRNLAHIKSQTQLTGDLGI 219
            .::.|::.|::    |..:.....:.:..|::.||        .||.:.|...|.:....|:|..
Yeast    67 NNIYPALVLAL----PYRDRRIYNIKDYVLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNLSS 127

  Fly   220 VAEQSRVSQRMMFQPAPLNVRDVFRKLREIAK---LSGQSKMDLVYNM-FVACRSS----EARFF 276
            :..:....:|.......:.:.:|...|..::.   .||:....||.:. |:.|..:    |.::|
Yeast   128 LLVEEIAKRRAEPSSKAITIDNVNHYLDSLSGDRFASGRGFKSLVKSKPFLHCVENMSFVELKYF 192

  Fly   277 IRSLIGKLRIGIAEQSLLTALAIGLVKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYD 341
            ...::....||..|..||...        |.|   |.....|..|..|.|:.|          ||
Yeast   193 FDIVLKNRVIGGQEHKLLNCW--------HPD---AQDYLSVISDLKVVTSKL----------YD 236

  Fly   342 IIIPAI-LKYDIKELQERCPMHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHR 405
               |.: ||.|...::      .|....|.||:.....:|...|........|.|.||||.|:|.
Yeast   237 ---PKVRLKDDDLSIK------VGFAFAPQLAKKVNLSYEKICRTLHDDFLVEEKMDGERIQVHY 292

  Fly   406 NEKGE-ISIFSRNSENNTAKYPDLIARST----ALLKGDVKSYIIDSEIVAWDVERKQILPF--- 462
            ...|| |..|||...:.|..|...::..|    ......||..::|.|:|.:|.:|:.||||
Yeast   293 MNYGESIKFFSRRGIDYTYLYGASLSSGTISQHLRFTDSVKECVLDGEMVTFDAKRRVILPFGLV 357

  Fly   463 -----QVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKF 522
                 :.||.....|||...:.:     :|||||:|||:|....|.:|::.|......::...:.
Yeast   358 KGSAKEALSFNSINNVDFHPLYM-----VFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKNIVEI 417

  Fly   523 ATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLV 587
            ..:.....::.:::.||.:|....||:::|..:  ::|.:|.|:.||:|:|.:||...|::|||:
Yeast   418 VRSSRCYGVESIKKSLEVAISLGSEGVVLKYYN--SSYNVASRNNNWIKVKPEYLEEFGENLDLI 480

  Fly   588 VIGGYKGKGRRTGTYGGFLLACYDTENEEYQ------------------------------SICK 622
            ||      ||.:|....|:|.....:.|||:                              |.|.
Yeast   481 VI------GRDSGKKDSFMLGLLVLDEEEYKKHQGDSSEIVDHSSQEKHIQNSRRRVKKILSFCS 539

  Fly   623 IGTGFTDE-----DLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQ--VWEVKCADLSLSP 680
            |..|.:.|     |.:|...:......:...|...:...: |..|.:|.:  |.|:|...|..:.
Yeast   540 IANGISQEEFKEIDRKTRGHWKRTSEVAPPASILEFGSKI-PAEWIDPSESIVLEIKSRSLDNTE 603

  Fly   681 IHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNN------------ 733
            .:.....     ...:|......|||.||   ..||...:..:|:|: .||:|
Yeast   604 TNMQKYA-----TNCTLYGGYCKRIRYDK---EWTDCYTLNDLYESR-TVKSNPSYQAERSQLGL 659

  Fly   734 -QKSSTQMEMEDEFY 747
             :|...::.:.|.|:
Yeast   660 IRKKRKRVLISDSFH 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	164/726 (23%)
DNL4	NP_014647.1	dnl1	84..717	CDD:273147	150/644 (23%)
		BRCT_DNA_ligase_IV_rpt1	690..782	CDD:349354
		BRCT_MDC1_rpt1	837..934	CDD:349375