DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAlig1 and ATLIG4

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_568851.2	Gene:	ATLIG4 / 835822	AraportID:	AT5G57160	Length:	1219	Species:	Arabidopsis thaliana

Alignment Length:	727	Identity:	180/727 - (24%)
Similarity:	301/727 - (41%)	Gaps:	209/727 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 YLALARTFQVIEETKGR-------LKMIDTL---SNFFCSVMLVSPEDLVPSVYLSINQLAPAYE 181
            :..|...|..|:::|..       .|.:||.   |::|.:|.|:.|         |:::...:|
plant     7 FSVLVSLFNWIQKSKTSSQKRSKFRKFLDTYCKPSDYFVAVRLIIP---------SLDRERGSY- 61

  Fly   182 GLELGVAETTLMKAI--------------------CKATGRNLAHIKSQTQLTGDLGIVAEQSRV 226
            ||:..|..|.|:.|:                    .|| |.|          .|:..::|.:. :
plant    62 GLKESVLATCLIDALGISRDAPDAVRLLNWRKGGTAKA-GAN----------AGNFSLIAAEV-L 114

  Fly   227 SQRMMFQPAPLNVRDVFRKLREIAKLSGQSKMDLVYNMFV-ACRSSEARFFIRSLIGKLRIGIAE 290
            .:|.......|.::::...|..:|....:::..||.:..: ...:.|.::.||.::..|::|::|
plant   115 QRRQGMASGGLTIKELNDLLDRLASSENRAEKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSE 179

  Fly   291 QSLLTALAIGLVKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKEL 355
            :|:.        ::.|         ||.  :::.:.|       |.           ||...::|
plant   180 KSIF--------QEFH---------PDA--EDLFNVT-------CD-----------LKLVCEKL 207

  Fly   356 QERCPMHP------GMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIF 414
            ::|...|.      |..:||.||.....|:..:::..|..:..|.|:||:|.|||:|.. :|..|
plant   208 RDRHQRHKRQDIEVGKAVRPQLAMRIGDVNAAWKKLHGKDVVAECKFDGDRIQIHKNGT-DIHYF 271

  Fly   415 SRN----SENNTAKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPF---QVLSTRKRKN 472
            |||    ||...| ..|||.::..     |...|:|.|::.||....:...|   |.::...|:.
plant   272 SRNFLDHSEYAHA-MSDLIVQNIL-----VDKCILDGEMLVWDTSLNRFAEFGSNQEIAKAAREG 330

  Fly   473 VDIEEIKVQVCVYIFDLLYINGTALVTKNLSERRKLL----------LE----------HFQEVE 517
            :|..:   |:|...||:||:..|:::.::|.||.:||          ||          |....|
plant   331 LDSHK---QLCYVAFDVLYVGDTSVIHQSLKERHELLKKVVKPLKGRLEVLVPEGGLNVHRPSGE 392

  Fly   518 GEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSNVGD 582
            ..|    ::..:...:|::|.:|:::...||:::|  |.|:.:|...||..|:|||.:|: ..|.
plant   393 PSW----SIVVHAAADVERFFKETVENRDEGIVLK--DLESKWEPGDRSGKWMKLKPEYI-RAGA 450

  Fly   583 SLDLVVIGGYKGKGRRTGTYGGFLLACYDTEN-----EEYQSICKIGTGFTDEDLQTHSEFLGKH 642
            .||:::||||.|.|||.|....||:|..|...     ..:.|.|::|||.:|::|.|
plant   451 DLDVLIIGGYYGSGRRGGEVAQFLVALADRAEANVYPRRFMSFCRVGTGLSDDELNT-------- 507

  Fly   643 VTSAAKSYYRYD-------PSL---------EPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDG 691
            |.|..|.|:|.:       ||.         .||.|.:              ||.....:.|...
plant   508 VVSKLKPYFRKNEHPKKAPPSFYQVTNHSKERPDVWID--------------SPEKSIILSITSD 558

  Fly   692 ERGI---------SLRFPRFIRIRDDK---------------NSENATDANQVAHMYQSQDQVKN 732
            .|.|         ||||||..::|.||               ||.|.|...| .....:||..|.
plant   559 IRTIRSEVFVAPYSLRFPRIDKVRYDKPWHECLDVQAFVELVNSSNGTTQKQ-KESESTQDNPKV 622

  Fly   733 NQKSSTQMEMED 744
            | |||.:.|.::
plant   623 N-KSSKRGEKKN 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	180/727 (25%)
		DNA_ligase_A_N	126..292	CDD:282522	38/195 (19%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	71/250 (28%)
		OBF_DNA_ligase_I	581..726	CDD:153438	53/189 (28%)
ATLIG4	NP_568851.2	dnl1	61..600	CDD:273147	154/627 (25%)
		BRCT_DNA_ligase_IV_rpt1	655..741	CDD:349354
		BRCT_DNA_ligase_IV_rpt2	802..898	CDD:349349
		PTZ00121	<909..>1180	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820