DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNAlig1 and lig3

DIOPT Version :10

Sequence 1:NP_611843.2 Gene:DNAlig1 / 37791 FlyBaseID:FBgn0262619 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_001025345.2 Gene:lig3 / 563276 ZFINID:ZDB-GENE-030131-8453 Length:1011 Species:Danio rerio


Alignment Length:800 Identity:200/800 - (25%)
Similarity:333/800 - (41%) Gaps:150/800 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ITSFFKKKSDATDSPSPPKKVPKIDAKTELPDE------PHIKSESASPETKPKVE---PMSVDS 60
            :...|:|...|..:....:.:.:::...||.||      .|:...:|...:.||.:   .::...
Zfish   139 VKCIFEKLERARATTKKIEDITELEGWEELQDEDKDLINKHVSELAAKVNSTPKKKVQAKLNTSG 203

  Fly    61 EEKTSPVKNVKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADSYHPLKNAYWKDKKVT 125
            :..:.|.......|::....|              |||....:..|......|.:.:....:...
Zfish   204 QLSSPPADPTVNAPRKFSGFT--------------ATKAGSSSSSPGPSPAKPAQGSVLSAQMCD 254

  Fly   126 PYLA--LARTFQ----VIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGLE 184
            |...  |.|.|:    ::.|..|.....:.:.:|.....  ..:.....:||::..|.|      
Zfish   255 PTHKDNLLREFRKLCALVAEKSGYNAKTEIVRDFLTKGS--GGDKFRGDLYLTVKLLLP------ 311

  Fly   185 LGVAETTLM---KAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQ--RMMFQPAP-------- 236
             ||.:....   |.|.|...|.|.  .:|..:..||    ||..||:  ||.|:.:.        
Zfish   312 -GVVKNVYNLNDKQIVKLFSRILN--CNQDDMVQDL----EQGDVSETVRMFFEESKSFPPSAKS 369

  Fly   237 -LNVRDVFRKLREIAKLSGQSKMDL-VYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTALAI 299
             |.:::|...|..:::|:.:..... :.::...|..::.:.:||.:...|:|....:.:|.|   
Zfish   370 LLTIQEVDASLSRLSQLTKEDDQQAELQSIAKKCTGNDLKCYIRLVKHDLKINSGAKHILDA--- 431

  Fly   300 GLVKKNHIDDCKASKVPDVYKDEIVDTTLLLK--TAYCQCPNYDIIIPAILKYDIKELQERCPMH 362
              |..|..|..|||:    ...:::|..|..:  .:....|...:.|.|.|.             
Zfish   432 --VDPNAYDAFKASR----NLGDVIDRVLRNQQDASNGTGPRKILSIEASLM------------- 477

  Fly   363 PGMPLRPMLAQPTKGVHEVFERF-GGMQITCEWKYDGERAQIHRNEKGEISIFSRNSE----NNT 422
              .|::||||:..|.:....::. .||.  .|.||||||.|:|:| ....|.|||:.:    :..
Zfish   478 --TPVQPMLAEACKSIEYAMKKCPNGMY--SEIKYDGERVQVHKN-GNHFSYFSRSLKPVLPHKV 537

  Fly   423 AKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIF 487
            |.:.|.|.::.|    ...|.|:|:|::..|.:..:.|||..|...|:....    ..||.:::|
Zfish   538 AHFKDFIPQAFA----GGHSMILDAEVLLIDTKTSKPLPFGTLGVHKKAAFQ----DAQVGLFVF 594

  Fly   488 DLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVK 552
            |.:|.||.:|:.|.|.||||.|.::..||.....|:.........::.:.:...|:...|||::|
Zfish   595 DCIYFNGVSLMDKPLCERRKFLHDNMVEVPNRILFSEMKHVTRAPDLAEMITRVIREGLEGLVLK 659

  Fly   553 TLDEEATYEIAKRSRNWLKLKKDYLSN--VGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENE 615
              |.:..||..|  |:|||:|||||:.  :.|:.||||:|.:.|||...|....||:.|||.|:.
Zfish   660 --DIKGLYEPGK--RHWLKVKKDYLNEGAMADTADLVVLGAFYGKGSNGGIMSSFLMGCYDPESR 720

  Fly   616 EYQSICKIGTGFTD---EDLQTHSEF--LGKHVT------SAAKSYYR----YDPSLEPDHWFEP 665
            ::.::.|...||.|   :.||...:.  :||..:      ...|:||.    .||...|      
Zfish   721 KWCTVTKCSGGFDDAMLDRLQKDLDVIKIGKDPSKIPGWLKIVKNYYPDFIIRDPQKAP------ 779

  Fly   666 VQVWEVKCADLSLSPIHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQ----- 725
              |||:..|:.|.|.:|.|        .|||:||||..|:||||:.:.||:..|:..:|:     
Zfish   780 --VWEITGAEFSKSEMHTA--------DGISIRFPRCTRMRDDKDWKTATNLQQLKELYRISKEN 834

  Fly   726 -------SQDQVKNNQKSST 738
                   ...:...|.|||:
Zfish   835 CDFEVTAGPSKANQNDKSSS 854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNAlig1NP_611843.2 PLN03113 1..745 CDD:215584 200/799 (25%)
lig3NP_001025345.2 zf-PARP 95..180 CDD:459887 7/40 (18%)
dnl1 317..829 CDD:273147 163/572 (28%)
LIG3_BRCT 935..1005 CDD:465260
Blue background indicates that the domain is not in the aligned region.

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