DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and lig3

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001025345.2	Gene:	lig3 / 563276	ZFINID:	ZDB-GENE-030131-8453	Length:	1011	Species:	Danio rerio

Alignment Length:	800	Identity:	200/800 - (25%)
Similarity:	333/800 - (41%)	Gaps:	150/800 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ITSFFKKKSDATDSPSPPKKVPKIDAKTELPDE------PHIKSESASPETKPKVE---PMSVDS 60
            :...|:|...|..:....:.:.:::...||.||      .|:...:|...:.||.:   .::...
Zfish   139 VKCIFEKLERARATTKKIEDITELEGWEELQDEDKDLINKHVSELAAKVNSTPKKKVQAKLNTSG 203

  Fly    61 EEKTSPVKNVKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADSYHPLKNAYWKDKKVT 125
            :..:.|.......|::....|              |||....:..|......|.:.:....:...
Zfish   204 QLSSPPADPTVNAPRKFSGFT--------------ATKAGSSSSSPGPSPAKPAQGSVLSAQMCD 254

  Fly   126 PYLA--LARTFQ----VIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGLE 184
            |...  |.|.|:    ::.|..|.....:.:.:|.....  ..:.....:||::..|.|
Zfish   255 PTHKDNLLREFRKLCALVAEKSGYNAKTEIVRDFLTKGS--GGDKFRGDLYLTVKLLLP------ 311

  Fly   185 LGVAETTLM---KAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQ--RMMFQPAP-------- 236
             ||.:....   |.|.|...|.|.  .:|..:..||    ||..||:  ||.|:.:.
Zfish   312 -GVVKNVYNLNDKQIVKLFSRILN--CNQDDMVQDL----EQGDVSETVRMFFEESKSFPPSAKS 369

  Fly   237 -LNVRDVFRKLREIAKLSGQSKMDL-VYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTALAI 299
             |.:::|...|..:::|:.:..... :.::...|..::.:.:||.:...|:|....:.:|.|
Zfish   370 LLTIQEVDASLSRLSQLTKEDDQQAELQSIAKKCTGNDLKCYIRLVKHDLKINSGAKHILDA--- 431

  Fly   300 GLVKKNHIDDCKASKVPDVYKDEIVDTTLLLK--TAYCQCPNYDIIIPAILKYDIKELQERCPMH 362
              |..|..|..|||:    ...:::|..|..:  .:....|...:.|.|.|.
Zfish   432 --VDPNAYDAFKASR----NLGDVIDRVLRNQQDASNGTGPRKILSIEASLM------------- 477

  Fly   363 PGMPLRPMLAQPTKGVHEVFERF-GGMQITCEWKYDGERAQIHRNEKGEISIFSRNSE----NNT 422
              .|::||||:..|.:....::. .||.  .|.||||||.|:|:| ....|.|||:.:    :..
Zfish   478 --TPVQPMLAEACKSIEYAMKKCPNGMY--SEIKYDGERVQVHKN-GNHFSYFSRSLKPVLPHKV 537

  Fly   423 AKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIF 487
            |.:.|.|.::.|    ...|.|:|:|::..|.:..:.|||..|...|:....    ..||.:::|
Zfish   538 AHFKDFIPQAFA----GGHSMILDAEVLLIDTKTSKPLPFGTLGVHKKAAFQ----DAQVGLFVF 594

  Fly   488 DLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVK 552
            |.:|.||.:|:.|.|.||||.|.::..||.....|:.........::.:.:...|:...|||::|
Zfish   595 DCIYFNGVSLMDKPLCERRKFLHDNMVEVPNRILFSEMKHVTRAPDLAEMITRVIREGLEGLVLK 659

  Fly   553 TLDEEATYEIAKRSRNWLKLKKDYLSN--VGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENE 615
              |.:..||..|  |:|||:|||||:.  :.|:.||||:|.:.|||...|....||:.|||.|:.
Zfish   660 --DIKGLYEPGK--RHWLKVKKDYLNEGAMADTADLVVLGAFYGKGSNGGIMSSFLMGCYDPESR 720

  Fly   616 EYQSICKIGTGFTD---EDLQTHSEF--LGKHVT------SAAKSYYR----YDPSLEPDHWFEP 665
            ::.::.|...||.|   :.||...:.  :||..:      ...|:||.    .||...|
Zfish   721 KWCTVTKCSGGFDDAMLDRLQKDLDVIKIGKDPSKIPGWLKIVKNYYPDFIIRDPQKAP------ 779

  Fly   666 VQVWEVKCADLSLSPIHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQ----- 725
              |||:..|:.|.|.:|.|        .|||:||||..|:||||:.:.||:..|:..:|:
Zfish   780 --VWEITGAEFSKSEMHTA--------DGISIRFPRCTRMRDDKDWKTATNLQQLKELYRISKEN 834

  Fly   726 -------SQDQVKNNQKSST 738
                   ...:...|.|||:
Zfish   835 CDFEVTAGPSKANQNDKSSS 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	200/799 (25%)
		DNA_ligase_A_N	126..292	CDD:282522	37/186 (20%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	69/222 (31%)
		OBF_DNA_ligase_I	581..726	CDD:153438	54/171 (32%)
lig3	NP_001025345.2	zf-PARP	95..178	CDD:279039	7/38 (18%)
		DNA_ligase_A_N	263..428	CDD:282522	35/179 (20%)
		dnl1	317..829	CDD:273147	163/572 (28%)
		Adenylation_DNA_ligase_III	467..679	CDD:185712	72/241 (30%)
		OBF_DNA_ligase_III	685..823	CDD:153436	52/153 (34%)
		LIG3_BRCT	935..1006	CDD:293364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820