DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and lig1

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_002941929.1	Gene:	lig1 / 100271763	XenbaseID:	XB-GENE-1009779	Length:	1040	Species:	Xenopus tropicalis

Alignment Length:	787	Identity:	412/787 - (52%)
Similarity:	538/787 - (68%)	Gaps:	57/787 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKKSDATDSPSPPKKVPK---------IDAKTELPDEPHIK--SESASPETKPKVEPMSVDSEEK 63
            |:....:.||:...|.||         :..|.:..|:...|  ||..|.|.|...||     |:|
Frog   262 KELQPKSTSPNSKPKTPKAKSGKKHSPLQKKVKFSDKVSSKDDSEGKSSEEKSDEEP-----EKK 321

  Fly    64 TSPVKNVKK-----EPKEVDDKT-------TDKKVTTIGLNSTAATK---------------EDV 101
            ..|.|.||:     .||:...||       .:|..:...|.::...|               ||.
Frog   322 ADPAKPVKQISSFFAPKKPAIKTEKKEEIMNEKNASETSLEASPKPKKTVSSFFGAIKPEPSEDQ 386

  Fly   102 ENYDPSADSYHPLKNAYWKDKKVTPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLV 166
            ..|:||..||||:.:|.|.:.:..||||:||||:.|||...|||.|:|||||..||:.::|.||:
Frog   387 AVYNPSKSSYHPINDACWSNGQKVPYLAVARTFERIEEESARLKNIETLSNFLRSVIALTPGDLL 451

  Fly   167 PSVYLSINQLAPAYEGLELGVAETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMM 231
            |.:||.:|:|.|||||||||:.||.||||:.:||||.|..|||:.|..||||:|||.||.:||.|
Frog   452 PCIYLCLNRLGPAYEGLELGIGETILMKAVAQATGRQLEKIKSEAQEKGDLGLVAESSRSNQRTM 516

  Fly   232 FQPAPLNVRDVFRKLREIAKLSGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQS 292
            |.|..|....||.||::||:::|.:    |:|::..:|||||.||||:..|||.||||||:||||
Frog   517 FTPPKLMASGVFSKLKDIARMTGNASMNKKIDIIKGLFVACRHSEARYIARSLGGKLRIGLAEQS 581

  Fly   293 LLTAL--AIGLVKKNH-----IDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKY 350
            :|:|:  |:.|....|     :.|.......|..|..|.|..::||..:|:.||||.|||.:|::
Frog   582 VLSAIAQAVCLTPPGHDAPPTVMDAGKGMSTDARKSWIEDKAMILKQTFCELPNYDAIIPILLEH 646

  Fly   351 DIKELQERCPMHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFS 415
            .|.:|.:.|.:.||:||:||||.||||:.||.:||.....|||:||||||||||..|.||:.|:|
Frog   647 GIDDLPKHCRLTPGIPLKPMLAHPTKGIGEVLKRFDEAAFTCEYKYDGERAQIHILENGEVHIYS 711

  Fly   416 RNSENNTAKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKV 480
            ||.||||.||||:|:|...:.|..|||.|:|:|.||||.|:|||.|||||:|||||:||..||||
Frog   712 RNQENNTTKYPDIISRIPKIKKESVKSCILDTEAVAWDPEKKQIQPFQVLTTRKRKDVDASEIKV 776

  Fly   481 QVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGN 545
            |||||.||:||:||.:||.:..::||:||.:.|.|.|||:.|||.:||::.||:.:||::|||.:
Frog   777 QVCVYAFDMLYLNGESLVKEPFAKRRQLLRDSFLETEGEFMFATYMDTSNTDEISEFLDQSIKDS 841

  Fly   546 CEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACY 610
            |||||||||:::|||||||||.||||||||||..|||:|||||||.|.|||:|||.|||||||.|
Frog   842 CEGLMVKTLEQDATYEIAKRSHNWLKLKKDYLEGVGDTLDLVVIGAYLGKGKRTGIYGGFLLASY 906

  Fly   611 DTENEEYQSICKIGTGFTDEDLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCAD 675
            |.|:||||:|||||||||||||:.|..:|..||..:.:||||:|.:.||||||:|||||||||||
Frog   907 DEESEEYQTICKIGTGFTDEDLEKHYNYLKDHVIDSPRSYYRWDSATEPDHWFDPVQVWEVKCAD 971

  Fly   676 LSLSPIHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQM 740
            ||:||:|:||:|:|:.|:|||||||||:||||||..|.||::.|||.:|:.|.|::|   ::|..
Frog   972 LSISPVHKAALGLVEDEKGISLRFPRFLRIRDDKKPEEATNSFQVADLYRKQQQIQN---TTTTE 1033

  Fly   741 EMEDEFY 747
            :.|::||
Frog  1034 KGEEDFY 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	410/783 (52%)
		DNA_ligase_A_N	126..292	CDD:282522	98/169 (58%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	137/217 (63%)
		OBF_DNA_ligase_I	581..726	CDD:153438	101/144 (70%)
lig1	XP_002941929.1	PTZ00121	<157..>369	CDD:173412	28/111 (25%)
lig1	XP_002941929.1	PLN03113	268..1020	CDD:215584	403/756 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1755
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	769	1.000	Inparanoid score	I534
OMA	1	1.010	-	-		QHG56362
OrthoDB	1	1.010	-	-		D182401at33208
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		oto104085
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080