DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg3 and alg3

DIOPT Version :9

Sequence 1:	NP_523829.2	Gene:	Alg3 / 37754	FlyBaseID:	FBgn0011297	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_593853.1	Gene:	alg3 / 2542768	PomBaseID:	SPAC7D4.06c	Length:	406	Species:	Schizosaccharomyces pombe

Alignment Length:	469	Identity:	160/469 - (34%)
Similarity:	227/469 - (48%)	Gaps:	89/469 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 YLLLEPAALPIVGLFVLLAELVINVVVIQRVPYTEIDWVAYMQECEGFLNGTTNYSLLRGDTGPL 101
            |..|.|:.|       ||.|:.....:|.:||||||||:|||::...||.|..:|..|.|.||||
pombe    22 YGWLHPSRL-------LLLEIPFVFAIISKVPYTEIDWIAYMEQVNSFLLGERDYKSLVGCTGPL 79

  Fly   102 VYPAAFVYIYSALYYVTSHGTNVRLAQYIFAGIYLLQLALVLRLYSKSRKVPPYVLVLSAFTSYR 166
            |||...|::|:.|||:|..|||:..||||||.:|.:..|:|..|: |..:.|.|:.|| ...|.|
pombe    80 VYPGGHVFLYTLLYYLTDGGTNIVRAQYIFAFVYWITTAIVGYLF-KIVRAPFYIYVL-LILSKR 142

  Fly   167 IHSIYVLRLFNDPVAVLLLYAALNLFL----DRRWTLGSTFFSLAVGVKMNILLFAPALLLFYLA 227
            :|||::||||||....|.    .:||:    .::|...|...|:|..|||:.||:.||.|:..|.
pombe   143 LHSIFILRLFNDGFNSLF----SSLFILSSCKKKWVRASILLSVACSVKMSSLLYVPAYLVLLLQ 203

  Fly   228 NLGLLRTILQLAVCGVIQLLLGAPFLLTHPVEYLRGSFDLGRIFEHKWTVNYRFLSRDLFENRTF 292
            .||..:|.:.:.|..::|:|...|| |.:...|...:||.||.|::|||||:||:.|.:||:.:|
pombe   204 ILGPKKTWMHIFVIIIVQILFSIPF-LAYFWSYWTQAFDFGRAFDYKWTVNWRFIPRSIFESTSF 267

  Fly   293 HVSLLGLHLLLLLAFAKPTWTFFQSYVRLRRIEDQLQPQIAQQNLELNAQKRPKKVEKDKDKDQK 357
            ..|:|.||:.||:||....|.      :|.|     ....|..|..|..:..||
pombe   268 STSILFLHVALLVAFTCKHWN------KLSR-----ATPFAMVNSMLTLKPLPK----------- 310

  Fly   358 KFTTEQQSFLKAFEKSLQKASGGKATPAPAQAEPERYGIHFDRCTQLALLPFFLCNLVGVACSRS 422
                            ||.|:......|.|.:                       ||:|:.|:||
pombe   311 ----------------LQLATPNFIFTALATS-----------------------NLIGILCARS 336

  Fly   423 LHYQFYVWYFHSLPYLAWSTPYSLGVRCLILGLIEYCWNTYPSTNFSSAALHFTHIILLAGVAKQ 487
            ||||||.|:....|||.:...:...:...:..|.||.||.:|||..||          |..|...
pombe   337 LHYQFYAWFAWYSPYLCYQASFPAPIVIGLWMLQEYAWNVFPSTKLSS----------LIAVCVP 391

  Fly   488 LVQTMRINNAAKRE 501
            |:..:::..:..|:
pombe   392 LITILKLYTSDYRK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg3	NP_523829.2	ALG3	51..470	CDD:282992	150/422 (36%)
alg3	NP_593853.1	ALG3	30..384	CDD:282992	151/428 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	269	1.000	Domainoid score	I336
eggNOG	1	0.900	-	-		E1_KOG2762
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4228
Inparanoid	1	1.050	269	1.000	Inparanoid score	I713
OMA	1	1.010	-	-		QHG53696
OrthoFinder	1	1.000	-	-		FOG0004953
OrthoInspector	1	1.000	-	-		oto101578
orthoMCL	1	0.900	-	-		OOG6_103036
Panther	1	1.100	-	-	LDO	PTHR12646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R42
SonicParanoid	1	1.000	-	-		X3495
TreeFam	1	0.960	-	-
	14	13.860