DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment angel and cnot6l

DIOPT Version :9

Sequence 1:	NP_477204.1	Gene:	angel / 37748	FlyBaseID:	FBgn0016762	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001018474.1	Gene:	cnot6l / 553665	ZFINID:	ZDB-GENE-050522-302	Length:	559	Species:	Danio rerio

Alignment Length:	374	Identity:	93/374 - (24%)
Similarity:	146/374 - (39%)	Gaps:	87/374 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RRWTSLGNQAEGRDPHKCSS-FKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLLRELLK 111
            |.|.:|    ..||....:: |.|:.||:|........|:.|  .|...|:|:.|::.::.|:..
Zfish   167 RPWITL----RERDQMMPTAVFTVMCYNVLCDKYATRQLYGY--CPSWALNWEYRKKGIMEEITN 225

  Fly   112 LDPDILCLQEMQFDHLPVLVQRLRMGNG-------KKLAYVYKKKTGCRTDGCAIVYDSSKFELL 169
            .|.||:.|||::.:.............|       |..|.:..::.....|||.:.:.:.||.|:
Zfish   226 CDADIISLQEVETEQYYTFFLETLKDRGYDGFFCPKSRAKLVSEQERKHVDGCGVFFKTEKFALV 290

  Fly   170 DHQAVELYDQAVA-------LLNR----DNVALFARFRFK--------KQQEQQKEFVVATTHLL 215
            ....||....|:|       :|||    ||:.:......|        |...:::..:||..|:.
Zfish   291 QKHTVEFNQVAMANSEGSEVMLNRVMTKDNIGVAVLLEVKEDLFAAGLKPPPEKQLLLVANAHMH 355

  Fly   216 FNTKRSDVRCAQVERILEELQSF----------------STDTPIVLTGDFNSLPDSSPIEFLV- 263
            ::.:.|||:..|....|.||:|.                ::..||||..|.||||||..:|:|.
Zfish   356 WDPEYSDVKLIQTMMFLSELKSIAERASGSINSSSPTSETSSIPIVLCADLNSLPDSGVVEYLSN 420

  Fly   264 -------------------------GKNGDVDSTACPEPLHFEIIDSGEGTASTYQNEWV----I 299
                                     ||||..|.:....   |::..:.||....|.|...    :
Zfish   421 GGVAENHKDFKELRYSDCLTNFSCNGKNGKPDGSITHS---FQLKSAYEGNLMPYTNYTYDFKGV 482

  Fly   300 VDYILRSLGSRSRHKLL-PLSVYSLPSINRCIGAGQIPNYRLGSDHYAL 347
            :|||..|....|...:| ||....|.. |...|.   |:..:.|||::|
Zfish   483 IDYIFFSKTHMSVLGVLGPLETQWLKD-NNITGC---PHPHIPSDHFSL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	87/351 (25%)
cnot6l	NP_001018474.1	Nuclease domain. /evidence=ECO:0000250	1..550		93/374 (25%)
		Required for interaction with cnot1, cnot3 and cnot7. /evidence=ECO:0000250	1..148
		leucine-rich repeat	32..52	CDD:275378
		LRR_8	51..107	CDD:290566
		LRR_4	51..91	CDD:289563
		leucine-rich repeat	53..75	CDD:275378
		leucine-rich repeat	76..98	CDD:275378
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..133	CDD:275378
		Deadenylase_CCR4b	186..533	CDD:197339	87/351 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740