Protein Alignment angel and ANGEL1

DIOPT Version :10

• Sequence 1: NP_477204.1
• Gene: angel / 37748
• FlyBaseID: FBgn0016762
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001357675.1
• Gene: ANGEL1 / 23357
• HGNCID: 19961
• Length: 744
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 104/300 - (34%)
• Similarity: 143/300 - (47%)
• Gaps: 37/300 - (12%)

  Fly    48 RRWTSLGNQAE------GRDPHKCSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLL 106
            |.|.....|.:      |..|.  ..|.::|||||||||:.:...||:....:.|:|..|..||:
Human   221 REWEDFSTQPDAQGLKAGDGPQ--FQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLM 283

  Fly   107 RELLKLDPDILCLQEMQFDHL-PVLVQRLRMGNGKKLAYVYKKKTGCRTDGCAIVYDSSKFELLD 170
            :|....|||||||||:|.||. ..|...|||   ......||::|||:|||||:.|..::|.||.
Human   284 QEFQHWDPDILCLQEVQEDHYWEQLEPSLRM---MGFTCFYKRRTGCKTDGCAVCYKPTRFRLLC 345

  Fly   171 HQAVELYDQAVALLNRDNVALFARFR----FKKQQEQQKEFVVATTHLLFNTKRSDVRCAQVERI 231
            ...||.:...:.|||||||.|....:    ....|.......||.||:|:|.:|.||:.||:..:
Human   346 ASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHILYNPRRGDVKLAQMAIL 410

  Fly   232 LEELQ-----SFSTDTPIVLTGDFNSLPDSSPIEFLVGKNGDVDSTACPEPLHFEIIDSGE--GT 289
            |.|:.     |..:..||:|.||.||:|||....|:  ::|::.....|......::...|  ||
Human   411 LAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFI--RDGELQYHGMPAWKSLALLPRLECNGT 473

  Fly   290 ASTYQNEWVIVDYILRSLGSRSRHKLLPLSVYSLPSINRC 329
            .|.:.|        |..|||...    |.|...:..|..|
Human   474 ISAHCN--------LCLLGSCDS----PASASQVAGITGC 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:469791	97/271 (36%)
ANGEL1	NP_001357675.1	EEP	248..>449	CDD:469791	83/205 (40%)