Protein Alignment angel and ANGEL1

DIOPT Version :9

• Sequence 1: NP_477204.1
• Gene: angel / 37748
• FlyBaseID: FBgn0016762
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001357675.1
• Gene: ANGEL1 / 23357
• HGNCID: 19961
• Length: 744
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 104/300 - (34%)
• Similarity: 143/300 - (47%)
• Gaps: 37/300 - (12%)

  Fly    48 RRWTSLGNQAE------GRDPHKCSSFKVVSYNILAQDLLLEHLFLYVGIPHEFLSWQRRQQNLL 106
            |.|.....|.:      |..|.  ..|.::|||||||||:.:...||:....:.|:|..|..||:
Human   221 REWEDFSTQPDAQGLKAGDGPQ--FQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLM 283

  Fly   107 RELLKLDPDILCLQEMQFDHL-PVLVQRLRMGNGKKLAYVYKKKTGCRTDGCAIVYDSSKFELLD 170
            :|....|||||||||:|.||. ..|...|||   ......||::|||:|||||:.|..::|.||.
Human   284 QEFQHWDPDILCLQEVQEDHYWEQLEPSLRM---MGFTCFYKRRTGCKTDGCAVCYKPTRFRLLC 345

  Fly   171 HQAVELYDQAVALLNRDNVALFARFR----FKKQQEQQKEFVVATTHLLFNTKRSDVRCAQVERI 231
            ...||.:...:.|||||||.|....:    ....|.......||.||:|:|.:|.||:.||:..:
Human   346 ASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHILYNPRRGDVKLAQMAIL 410

  Fly   232 LEELQ-----SFSTDTPIVLTGDFNSLPDSSPIEFLVGKNGDVDSTACPEPLHFEIIDSGE--GT 289
            |.|:.     |..:..||:|.||.||:|||....|:  ::|::.....|......::...|  ||
Human   411 LAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFI--RDGELQYHGMPAWKSLALLPRLECNGT 473

  Fly   290 ASTYQNEWVIVDYILRSLGSRSRHKLLPLSVYSLPSINRC 329
            .|.:.|        |..|||...    |.|...:..|..|
Human   474 ISAHCN--------LCLLGSCDS----PASASQVAGITGC 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
angel	NP_477204.1	EEP	70..351	CDD:294334	97/271 (36%)
ANGEL1	NP_001357675.1	EEP	248..>449	CDD:351117	83/205 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143749
Domainoid	1	1.000	135	1.000	Domainoid score	I4986
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32251
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4594
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395901at33208
OrthoFinder	1	1.000	-	-		FOG0002618
OrthoInspector	1	1.000	-	-		otm40331
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3577
SonicParanoid	1	1.000	-	-		X1517
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890