Protein Alignment l(2)efl and HSPB1

DIOPT Version :10

• Sequence 1: NP_523827.1
• Gene: l(2)efl / 37744
• FlyBaseID: FBgn0011296
• Length: 187
• Species: Drosophila melanogaster
• Sequence 2: NP_001531.1
• Gene: HSPB1 / 3315
• HGNCID: 5246
• Length: 205
• Species: Homo sapiens
• Alignment Length: 203
• Identity: 77/203 - (37%)
• Similarity: 105/203 - (51%)
• Gaps: 43/203 - (21%)

  Fly     8 FRDWWDELDFPMRTSRLLDQHFGQGLKRDDLMSSVW---NSRPTVLRSGYLRPW----------- 58
            ||||:..       |||.||.|  ||.|.....|.|   :|.|     ||:||.
Human    19 FRDWYPH-------SRLFDQAF--GLPRLPEEWSQWLGGSSWP-----GYVRPLPPAAIESPAVA 69

  Fly    59 ---HTNSLQKQESG--STLNIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDEHGYV 118
               ::.:|.:|.|.  |.:...::::.|.|||..|:|.|:|||..|..|.:.|||||:||||||:
Human    70 APAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYI 134

  Fly   119 SRQFSRRYQLPSDVNPDTVTSSLSSDGLLTIKAPMKALPPPQTERLVQIT------QTGPSSKED 177
            ||.|:|:|.||..|:|..|:||||.:|.||::|||..|.....|..:.:|      ..||.:
Human   135 SRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEA--- 196

  Fly   178 NAKKVETS 185
             ||..||:
Human   197 -AKSDETA 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)efl	NP_523827.1	metazoan_ACD	71..153	CDD:107247	41/81 (51%)
HSPB1	NP_001531.1	Interaction with TGFB1I1. /evidence=ECO:0000250	70..205		56/138 (41%)
		ACD_HspB1_like	84..169	CDD:107230	42/84 (50%)